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RISS 인기검색어
- 검색키워드
- 저자 : Wolfgang Meyerhof (검색결과 1 건)
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Vida Bitarafan,Penelope C E Fitzgerald,Tanya J Little,Wolfgang Meyerhof,Tongzhi Wu,Michael Horowitz,Christine Feinle-Bisset 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.3
Background/AimsNutrient-induced gut hormone release (eg, cholecystokinin [CCK]) and the modulation of gut motility (particularly pyloric stimulation)contribute to the regulation of acute energy intake. Non-caloric bitter compounds, including quinine, have recently been shownin cell-line and animal studies to stimulate the release of gastrointestinal hormones by activating bitter taste receptors expressedthroughout the gastrointestinal tract, and thus, may potentially suppress energy intake without providing additional calories. Thisstudy aims to evaluate the effects of intraduodenally administered quinine on antropyloroduodenal pressures, plasma CCK and energyintake. MethodsFourteen healthy, lean men (25 ± 5 years; BMI: 22.5 ± 2.0 kg/m2) received on 4 separate occasions, in randomized, double-blindfashion, 60-minute intraduodenal infusions of quinine hydrochloride at doses totaling 37.5 mg (“Q37.5”), 75 mg (“Q75”) or 225 mg(“Q225”), or control (all 300 mOsmol). Antropyloroduodenal pressures (high-resolution manometry), plasma CCK (radioimmunoassay),and appetite perceptions/gastrointestinal symptoms (visual analog questionnaires) were measured. Ad libitum energy intake(buffet-meal) was quantified immediately post-infusion. Oral quinine taste-thresholds were assessed on a separate occasion using3-alternative forced-choice procedure. ResultsAll participants detected quinine orally (detection-threshold: 0.19 ± 0.07 mmol/L). Intraduodenal quinine did not affect antral, pyloricor duodenal pressures, plasma CCK (pmol/L [peak]; control: 3.6 ± 0.4, Q37.5: 3.6 ± 0.4, Q75: 3.7 ± 0.3, Q225: 3.9 ± 0.4), appetiteperceptions, gastrointestinal symptoms or energy intake (kcal; control: 1088 ± 90, Q37.5: 1057 ± 69, Q75: 1029 ±7 0, Q225: 1077 ± 88). ConclusionQuinine, administered intraduodenally over 60 minutes, even at moderately high doses, but low infusion rates, does not modulateappetite-related gastrointestinal functions or energy intake.
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