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- 저자 : Winquist, Fredrik (검색결과 2 건)
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Malek B. Hannouf,Eric Winquist,Salaheddin M. Mahmud,Muriel Brackstone,Sisira Sarma,George Rodrigues,Peter K. Rogan,Jeffrey S. Hoch,Gregory S. Zaric 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1
Purpose The purpose of this study was to estimate the incidence of occult gastrointestinal (GI) primary tumours in patients with metastatic cancer of uncertain primary origin and evaluate their influence on treatments and overall survival (OS). Materials and Methods We used population heath data from Manitoba, Canada to identify all patients initially diagnosed with metastatic cancer between 2002 and 2011. We defined patients to have “occult” primary tumour if the primary was found at least 6 months after initial diagnosis. Otherwise, we considered primary tumours as “obvious.” We used propensity-score methods to match each patient with occult GI tumour to four patients with obvious GI tumour on all known clinicopathologic features. We compared treatments and 2-year survival data between the two patient groups and assessed treatment effect on OS using Cox regression adjustment. Results Eighty-three patients had occult GI primary tumours, accounting for 17.6% of men and 14% of women with metastatic cancer of uncertain primary. A 1:4 matching created a matched group of 332 patients with obvious GI primary tumour. Occult cases compared to the matched group were less likely to receive surgical interventions and targeted biological therapy, and more likely to receive cytotoxic empiric chemotherapeutic agents. Having an occult GI tumour was associated with reduced OS and appeared to be a nonsignificant independent predictor of OS when adjusting for treatment differences. Conclusion GI tumours are the most common occult primary tumours in men and the second most common in women. Patients with occult GI primary tumours are potentially being undertreated with available GI site-specific and targeted therapies.
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NEW ADVANCEMENTS IN GAS SENSITIVE FIELD EFFECT DEVICES : SENSOR ARRAYS FOR ODOUR IDENTIFICATION
Lundström, Ingemar,Holmberg, Martin,Sundgren, Hans,Winquist, Fredrik 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1
Several advancements are still made regarding gas sensitive field effect structures like the use of new gate materials, new semiconductor substrates for high temperature operation, the detection of new classes of molecules, and the develoμment of new models for the detection mechanisms. In this contribution we concentrate on sensor arrays with field effect devices. Models for the detection mechanism of gas sensitive field effect devices are first reviewed. An emphasis is put on the different possibilities to change the selectivity patterns of such devices. These are related to the choice of gate metal and operation temperature. It is shown how sensor arrays with different field effect devices combined with other types of sensors can be used for odour identification and classification purposes. More specifically an electronic nose consisting of ten of the MOSFET devices, four Taguchi sensors and a carbon dioxide monitor is described. Applications of the hybrid array for the classification of ground meat in terms of its age and of different qualities of packaging materials are two examples which are discussed.
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