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Han, Ah-Reum,Kang, You-Jin,Windono, Tri,Lee, Sang Kook,Seo, Eun-Kyoung 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.17
A new prenlated chalcone, 3"",3"" -dimethylpyrano[3',4']2,4,2' -trihydroxychalcone(1), was isolated from the heartwood of Artocarpus communis. Two flavonoid derivatives, (-)-cycloartocarpin(9) and (-)-cudraflavone A(10), were isolated as new isomers. In addition, eight known flavonoids, isobacachalcone(2), morachalcone A(3), gemichalcones B(4) and C(5), artocarpin(6), cudraflavone C(7), licoflavone C(8), and (2S)-euchrenone a_(7)(11), were isolated and identified from this plant for the first time. Compounds 1-4.6, and 11 exhibited potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC_(50) values of 18.8, 6.4, 16.4, 9.3, 18.7, and 12.3, μM, respectively. The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments.
Jang, Dae-Sik,Min, Hye-Young,Kim, Moon-Sun,Han, Ah-Reum,Windono, Tri,Jeohn, Gwang-Ho,Kang, Sam-Sik,Lee, Sang-Kook,Seo, Eun-Kyoung 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16
A new humulene sesqulterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxlde (2) were isolated from the rhizomes of Ziagiber zerumbet (Zinglberraceae), and found to Inhibit lipopolysaccharlde-Induced nitric oxide production in murlne macrophage RAW 264.7 cells with IC_(50) values of 14.1 and 23.5㎛, respectlvely, by bloassay-guided fractlonation (positive control: N^(ω) monomethyl-L-arginine, IC_(50)=21.3㎛). The structure of 1 was determined by spectroscopic methods Including 1D and 2D-NMR.