http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
Energy spread minimization in a cascaded laser wakefield accelerator via velocity bunching
Zhang, Zhijun,Li, Wentao,Liu, Jiansheng,Wang, Wentao,Yu, Changhai,Tian, Ye,Nakajima, Kazuhisa,Deng, Aihua,Qi, Rong,Wang, Cheng,Qin, Zhiyong,Fang, Ming,Liu, Jiaqi,Xia, Changquan,Li, Ruxin,Xu, Zhizhan American Institute of Physics 2016 Physics of plasmas Vol.23 No.5
Wentao He,Yong Yao,Min He,Zhang Kai,Lijuan Long,Minmin Zhang,Shuhao Qin,Jie Yu 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Surface modification of montmorillonite (MMT) with 3-glycidoxypropyl trimethoxysilane (3GTO) in mild methanol/water mixture has been investigated in detail. The influence of reaction conditions (including silane concentration in feed, reaction time and reaction temperature) on the grafting amount and yield of silane, and further on the grafting pattern of silanes was studied by thermogravimetric analysis, elemental analysis, X-ray diffraction (XRD) and BET. Higher silane concentration, longer reaction time and higher reaction temperature are all benefit to higher grafting amount. When the grafting reaction was performed with 3 mmol/g silane concentration, at 90 oC for 24 h, the grafted amount and yield of silane reached 1.4443 mmol/g and 30%, respectively. Based on the XRD and BET data analysis, a speculation that the grafting pattern of silanes was concentration dependence was proposed.
Surface Modification of Colloidal Silica Nanoparticles: Controlling the size and Grafting Process
Wentao He,Danhua Wu,Juan Li,Kai Zhang,Yushu Xiang,Lijuan Long,Shuhao Qin,Jie Yu,Qin Zhang 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.9
Surface modification of colloidal silica nanoparticles without disrupting the electric double layer of nanoparticles is a major challenge. In the work, silane was employed to modify colloidal silica nanoparticles without inducing bridge flocculation obviously. The effect of pH value of the silica sol, the amount of silane in feed, and reaction temperature on the graft amount and the final size of modified particles was investigated. The increased weight loss by TG and the appearance of T2 and T3 except for Q2 and Q3 signals by CP/MAS 29Si NMR of the modified samples verified the successful grafting of silane. The graft amount reached 0.57 mmol/ g, which was slightly lower than theory value, and the particle size remained nearly the same as unmodified particles for acidic silica sol at the optimum condition. For alkaline silica sol after modification, aggregates composed of several nanoparticles connected together with silane moleculars as the bridge appeared.
Zhang, Wentao,Xu, Yongxiang,Ren, Jingwei,Su, Jianyong,Zou, Jibin The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.6
Ear-piercing high-frequency noise from electromagnetic vibrations in motors has become unacceptable in sensitive environments, due to the application of pulse width modulation (PWM) and in consideration of switching losses. This paper proposed a synchronous periodic frequency modulation (SPFM) method based on the interleaving technique for paralleled three-phase voltage source inverters (VSIs) to eliminate PWM vibration noise. The proposed SPFM technique is able to effectively remove unpleasant high-frequency vibration noise as well as acoustic noise more effectively than the conventional periodic carrier frequency modulation (PCFM) and interleaving technique. It completely eliminates the vibration noise near odd-order carrier frequencies and reduces the PWM vibration noise near even-order carrier frequencies depending on the switching frequency variation range. Furthermore, the SPFM method is simple to implement and does not employ additional circuits in the drive system. Finally, the effectiveness of the proposed method has been confirmed by detailed experimental results.
Grafting of poly(ethylene glycols) onto nanometer silica surface by 1,4-phenylene diisocyanate
Wentao Zhang,Hong-Ro Lee 한국표면공학회 2010 한국표면공학회 학술발표회 초록집 Vol.2010 No.5
Polyethylene glycol (PEG) molecules have been grafted onto the surface of nanometer silica intoluenebyusing1,4-phenylene diisocyanate (PPDI) as a coupling agent, and dibutyltion dilaurate (DBTDL) as a catalyst. This process was executed by using a one-step procedure involving a first reaction of PPDI with silica and a subsequent reaction of isocyanate-bound silica with PEG. Optimum grafting conditions of PEG were obtained at the temperature of 80 ℃ for 8 h. Maximum grafting of PEG molecules ratio was 22.6%, and maximum overall grafting ratio was 35%, as determined by TGA.
Zhang Fei,Peng Wuxun,Wang Tao,Zhang Jian,Dong Wentao,Wang Chuan,Xie Zhihong,Luo Hong,Liu Gang 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Bone marrow mesenchymal stem cells (BMSCs) have been used in the treatment of early steroid-induced osteonecrosis of the femoral head (SONFH). However, the hypoxic microenvironment in the osteonecrotic area leads to hypoxia-induced apoptosis of transplanted BMSCs, which limits their efficacy. Therefore, approaches that inhibit hypoxia-induced apoptosis of BMSCs are promising for augmenting the efficacy of BMSC transplantation. Our present study found that under hypoxia, the expression of the long noncoding RNA (Lnc) transmembrane protein 235 (Tmem235) was downregulated, the expression of Bcl-2-associated X protein was upregulated, the expression of B-cell lymphoma-2 protein was downregulated, and the apoptotic rate of BMSCs was over 70%. However, overexpression of Lnc Tmem235 reversed hypoxia-induced apoptosis of BMSCs and promoted their survival. These results demonstrated that Lnc Tmem235 effectively inhibited hypoxia-induced apoptosis of BMSCs. Mechanistically, we found that Lnc Tmem235 exhibited competitive binding to miR-34a-3p compared with BIRC5 mRNA, which is an inhibitor of apoptosis; this competitive binding relieved the silencing effect of miR-34a-3p on BIRC5 mRNA to ultimately inhibit hypoxia-induced apoptosis of BMSCs by promoting the expression of BIRC5. Furthermore, we cocultured BMSCs overexpressing Lnc Tmem235 with xenogeneic antigen-extracted cancellous bone to construct tissue-engineered bone to repair a model of early SONFH in vivo. The results showed that overexpression of Lnc Tmem235 effectively reduced apoptosis of BMSCs in the hypoxic microenvironment of osteonecrosis and improved the effect of BMSC transplantation. Taken together, our findings show that Lnc Tmem235 inhibited hypoxia-induced apoptosis of BMSCs by regulating the miR-34a-3p/BIRC5 axis, thus improving the transplantation efficacy of BMSCs for treating early SONFH.
Wentao Zhang,Yongxiang Xu,Jingwei Ren,Jianyong Su,Jibin Zou 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.6
Ear-piercing high-frequency noise from electromagnetic vibrations in motors has become unacceptable in sensitive environments, due to the application of pulse width modulation (PWM) and in consideration of switching losses. This paper proposed a synchronous periodic frequency modulation (SPFM) method based on the interleaving technique for paralleled three-phase voltage source inverters (VSIs) to eliminate PWM vibration noise. The proposed SPFM technique is able to effectively remove unpleasant high-frequency vibration noise as well as acoustic noise more effectively than the conventional periodic carrier frequency modulation (PCFM) and interleaving technique. It completely eliminates the vibration noise near odd-order carrier frequencies and reduces the PWM vibration noise near even-order carrier frequencies depending on the switching frequency variation range. Furthermore, the SPFM method is simple to implement and does not employ additional circuits in the drive system. Finally, the effectiveness of the proposed method has been confirmed by detailed experimental results.