Mangiferin loaded magnetic PCEC microspheres: preparation, characterization and antitumor activity studies in vitro

WenJing Xiao,Jun Hou,Jie Ma,BoTao Yu,JianDong Ren,WeiHua Jin,Juan Wu,DeZhi Zheng,KaiHua Fan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8

Mangiferin is a promising effective chemopreventiveagent against various tumors. However, itsclinical use is limited by poor water solubility and lowbioavailability. In this article, mangiferin loaded magneticPCEC microspheres (MG-MS) were designed, characterizedand the antitumor activity of MG-MS was evaluatedin vitro. The magnetic nanoparticles (MNP) were synthesizedvia the high-temperature reaction of ironacetylacetonate in phenyl ether in the presence of oleic acidand oleylamine. Poly (ε-caprolactone)-poly (ethyleneglycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC)copolymers were formed by ring-opening copolymerizationof ε-CL initiated by PEG-diol using Sn(Oct)2 as acatalyst and MG-MS were prepared by solvent diffusionmethod. MNP, PCEC copolymer, and MG-MS werecharacterized by GPC, TEM, XRD, FT-IR, 1H-NMP andMalvern Laser Particle Sizer. Meanwhile, the antiproliferativeactivity in vitro and in vitro release behavior of thismicrospheres were studied in detail. The results indicatethat the obtained magnetic microspheres might have greatpotential as an effective carrier for mangiferin used incancer chemotherapy.

Power control of CiADS core with the intensity of the proton beam

Kai Yin,Wenjing Ma,Wenjuan Cui,Zhiyong He,Xinxin Li,Shiwu Dang,Feng Yang,Yuhui Guo,Limin Duan,Meng Li,Yikai Hou 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.4

This paper reports the control method for the core power of the China initiative Accelerator DrivenSystem (CiADS) facility. In the CiADS facility, an intense external neutron source provided by a protonaccelerator coupled to a spallation target is used to drive a sub-critical reactor. Without any control rodinside the sub-critical reactor, the core power is controlled by adjusting the proton beam intensity. Inorder to continuously change the beam intensity, an adjustable aperture is considered to be used at theLow Energy Beam Transport (LEBT) line of the accelerator. The aperture size is adjusted based on theProportional Integral Derivative (PID) controllers, by comparing either the setting beam intensity or thesetting core power with the measured value. To evaluate the proposed control method, a CiADS coremodel is built based on the point reactor kinetics model with six delayed neutron groups. The simulations based on the CiADS core model have indicated that the core power can be controlled stably byadjusting the aperture size. The response time in the adjustment of the core power depends mainly onthe adjustment time of the beam intensity

Study on Interleaved Three-Switch Buck-Boost Converters with Co-directional Coupling Inductor

Zhang Xianjin,Ma Wenjing,Zhu Hairong,Wu Di,Bi Shubo 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1

In order to obtain soft switching and simplify the controlling circuit of an interleaved two-switch Buck-Boost converter, two types of three-switch interleaved Buck-Boost converters are proposed in this paper. Firstly, this paper analyses the coupling process of the presented converters under a large coupling coefcient. Then, the operating principle of the two converters is given in detail. And it is concluded that the expended duty cycle and soft switching of most of power devices can be obtained and a sharing-current circuit is also not needed. This will deeply simplify the controlling circuit. Finally, the simulation and experimental results verify the analysis.

Lightweight design for the aluminum alloy-carbon fiber hybrid structure of the EMU car body

Yiming Shangguan,Wenjing Wang,Anrui He,Wenjun Ma,Honglei Tian 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.12

This paper presents an innovative electric multiple unit (EMU) car body lightweight design approach that integrates structural and material optimizations. The structural lightweight design was carried out by using a sub-frame-based method and the non-dominated genetic algorithm II. The plate thicknesses of 28 car body components were chosen as the optimization design variable. The lightweight material design was realized by replacing the aluminum alloy with composite material. The two-dimensional Hashin criterion was used to analyze and validate the strength of the composite driver’s cab. Results show that after size optimization, the structure weight of the vehicle was reduced from 10964 kg to 8661 kg, which was 21.01 % less than the initial configuration. This modular lightweight design strategy for EMU car body optimization offers valuable insights that could be taken into account in future EMU car body designs.

Effect of novel intensification structure on drying of particulate materials in spouted beds

Shengning Zhao,Feng Wu,Xiao-Xun Ma,Wenjing Zhou 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-

Through the hot air-drying experiment, the differences in drying rate, unit energy consumption, and bedpressure drop of the conventional spouted bed (CSB), the spouted bed with an integral swirling bladenozzle (ISBN), the spouted bed with spherical longitudinal vortex generators (LVGs), and the integralmulti-jet spout-fluidized bed (IMJSFB) were studied. The Weibull distribution function was introducedto fit the drying data, and the differences in moisture diffusion coefficient, scale parameters, and dryingactivation energy of the four types of spouted beds were further discussed. The drying performanceparameters of the four types of spouted beds were comprehensively evaluated. The results show that,compared with the CSB, LVGs and IMJSFB reduce the activation energy of the drying process, while theISBN increases the activation energy of the drying process. The IMJSFB shows more excellent performancein terms of drying rate, scale parameters, unit energy consumption, and bed pressure drop, with the highestcomprehensive score. Compared with CSB, ISBN and LVGs, the IMJSFB is more suitable for drying wetparticles. For the IMJSFB, there exists an optimal value of particle diameter (d = 2 mm) for the drying process,which makes the particle drying rate reach maximum.

Facile Synthesis of MoS2 Hierarchical Nanostructures as Electrodes for Capacitor with Enhanced Pseudocapacitive Property

Shiting Luo,Limei Xu,Jinshan Li,Wenjing Yang,Minli Liu,Lin Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.02

In this work, the 3D porous hierarchical MoS2 nanostructures were prepared via a simple hydrothermal deposition method only utilizing titanium (Ti) mesh as a substrate. The as-synthesized uniform MoS2 flower-like nanostructures were assembled by nanosheets composed of several stacking layers. The curved and rough surface of cylindrical Ti wire was beneficial to assembly of MoS2 nanosheets into hierarchical architectures. Moreover, the electrochemical performance of the as-prepared MoS2 nanostructured electrodes for capacitors was also investigated. The structural advantages lead to a remarkably improved pseudocapacitive property including high capacitance and durable cycling ability.

The physicochemical, antioxidant, hypoglycemic and prebiotic properties of γ-irradiated polysaccharides extracted from Lentinula edodes

Chaomin Yin,Chen Li,Kun Ma,Xiuzhi Fan,Fen Yao,Defang Shi,Wenjing Wu,Jianhui Qiu,Guoyuan Hu,Hong Gao 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.7

In this study, the influence of γ-irradiation with different dose (0, 4, 8, and 16 kGy) on chemical composition, physicochemical features and bioactivities of polysaccharides extracted from Lentinula edodes (LEP) were investigated. The carbohydrate content (from 59.47 to 70.96%), the solubility, the ⋅OH and DPPH scavenging ability of LEP increased with the increased γ-irradiation dose, while the protein content, the weight-average and number-average molecular weight of LEP were significantly decreased with the increased γ-irradiation dose. Moreover, γ-irradiation treatment caused LEP color changes and surface topography destroyed. γ-Irradiated LEP showed higher hypoglycemic activities in vitro than that of non-irradiated LEP. Moreover, γ-irradiated LEP had better proliferation promoting effects on Lactobacillus rhamnosus and L. plantarum. These results showed that γ-irradiation treatment changes the physicochemical features of LEP, thus affects its antioxidant, hypoglycemic and prebiotic properties, which suggests that γ-irradiated LEP has potential application in the pharmaceutical industries and functional foods.