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Weng Wenya,Ge Tingwen,Wang Yi,He Lulu,Liu Tinghao,Wang Wanning,Zheng Zongyu,Yu Lechu,Zhang Chi,Lu Xuemian 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.4
Background: Fibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg (Cryaa-Tag, Ins2-CALM1) 26OVE/PneJ (OVE26) transgenic mouse is a widely recommended mouse model to recapture the most important features of T1DM nephropathy that often occurs in diabetic patients. In addition, most previous studies focused on exploring the preventive effect of FGF21 on the development of DN. However, in clinic, development of therapeutic strategy has much more realistic value compared with preventive strategy since the onset time of DN is difficult to be accurately predicted. Therefore, in the present study OVE26 mice were used to investigate the potential therapeutic effects of FGF21 on DN. Methods: Four-month-old female OVE26 mice were intraperitoneally treated with recombinant FGF21 at a dose of 100 μg/kg/day for 3 months. The diabetic and non-diabetic control mice were treated with phosphate-buffered saline at the same volume. Renal functions, pathological changes, inflammation, apoptosis, oxidative stress and fibrosis were examined in mice of all groups. Results: The results showed that severe renal dysfunction, morphological changes, inflammation, apoptosis, and fibrosis were observed in OVE26 mice. However, all the renal abnormalities above in OVE26 mice were significantly attenuated by 3-month FGF21 treatment associated with improvement of renal adenosine 5´-monophosphate (AMP)-activated protein kinase (AMPK) activity and sirtuin 1 (SIRT1) expression. Conclusion: Therefore, this study demonstrated that FGF21 might exert therapeutic effects on DN through AMPK-SIRT1 pathway.
Solubility of N-ethylcarbazole in ethanol+petroleum ether mixtures at various temperatures
Wenge Yang,Keyi Wu,Yong-Hong Hu,Tuan Zhang,Qirun Guo,Shouhai Yang,Ying Shi 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6
The solubility of N-ethylcarbazole in (ethanol+petroleum ether) binary solvent mixtures was measured with the temperature changing from 280.15 K to 316.15 K. The experimental data matched the solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation. Computational results showed the CNIBS/R-K equation was more suitable than the Jouyban-Acree equation. The solution process in the thermodynamic properties, including the Gibbs energy, enthalpy, and entropy, was calculated by the van’t Hoff analysis.
Characterization of the B cell receptor repertoire of patients with acute coronary syndrome
Weng Ruiqiang,Liu Sudong,Gu Xiaodong,Zhong Zhixiong 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Acute coronary syndrome (ACS) is a complex cardiovascular disease whose development involves the dysregulation of adaptive immune responses. Though it has been proven that T cells associate with inflammation in the development of ACS, the function of B cells in disease remains unclear. Objective: The aim of this study was to reveal the diversity of the B cell receptor (BCR) repertoire of patients with ACS. Methods: We conducted a pilot study to sequence the immune repertoire of peripheral blood mononuclear cells (PBMCs) from patients with ACS, including acute myocardial infarction (AMI) and unstable angina (UA), and quantitatively characterized BCR repertoires by bioinformatics analysis. Results: We found that patients with AMI and UA had lower BCR repertoire diversity compared with controls with normal coronary arteries (NCA). Lower percentages of productive unique BCR nt sequences and higher percentages of top 200 unique BCR sequences were identified in AMI and UA patients than NCA controls. Patients had various preferential usage of V and J genes from B cell clones in accordance with the disease severity of coronary arteries. AMI patients had distinct CDR3 amino acids, and their frequency differed among patients with ACS. Conclusions: Our results indicate that differential BCR signatures represent an imprint of distinct repertoires among ACS patients. This study thereby opens up the prospect of studying disease-relevant B cells to better understand and treat ACS.
Weng, Jun,Zhang, Suping,Pan, Jingxi,Jinxing, Chen,Xu, Chunhe Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Direct EPR evidence of the photo-generation of superoxide radicals ( $O_2$$^{-.}$) was obtained by using spin trapping techniques in spinach photosystem II (PSII) membranes. $O_2$$^{-.}$ was detected by following the formation of 5-diethoxyphosphoryl-5-methyl-1 -pyrroline-N-oxide (DEPMPO) superoxide adducts, DEPMPO-OOH. The significant increase of the EPR signal amplitude of DEPMPO-OOH in N$H_2O$H-, CaC $l_2$- and NaCl-treated PSII membranes showed that the oxygen-evolving system has a close relation to the $O_2$$^{-.}$ production. PSII membranes with inactivated donor side could not prevent the $O_2$$^{-.}$ production efficiently. Treatments on PSII donor side also influence the maximum level and the kinetics of Chlorophyll (Chi) a fluorescence. Results suggested that manganese cluster and extrinsic proteins might affect Chi a fluorescence in ways different from that happens at the acceptor side of PSII.SII.SII.
A Multi-Domain Web Text Feature Extraction Model for e-Science Environment
Weng Yu 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.11
The traditional information extraction methods based on specific domain usually depend on the domain dictionaries to discover the text feature. It is inconvenient for reproducing and difficult to transplant in multi-domain environment. The application scope is limited seriously. Oriented to the deficiencies above, a multi-domain web text feature extraction model for e-Science is proposed (named e-FTM). This model adopts the Chinese split words technology without dictionary into the process of multi-domain text feature discovery and avoids the dependency of domain dictionaries effectively. With the help of classification of common and individual features, the model tracks the generation and the development trend of domain events dynamically, and forms a couple of local data centers eventually. Through cooperative scheduling the domain knowledge between different local data centers, the knowledge utilization efficiency of the domain information in the global scope is improved sharply. To validate the performance, the experiments on the multi-domain text feature extraction, topic features dynamical tracking and the domain knowledge cooperative scheduling demonstrate that the model has higher application validity and practicality in e-Science environment.
Weng, D.G.,Zhang, C.,Lu, X.L.,Zeng, S.,Zhang, S.M. Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.5
The passive energy dissipation technology has been proven to be reliable and robust for recent practical applications. Various dampers or energy dissipation devices have been widely used in building structures for enhancing their performances during earthquakes, windstorm and other severe loading scenarios. This paper presents a simplified seismic design procedure for retrofitting earthquake-damaged frames with viscous dampers. With the scheme of designing the main frame and the supplemental viscous dampers respectively, the seismic analysis model of damped structure with viscous dampers and braces was studied. The specific analysis process was described and approach to parameter design of energy dissipation components was also proposed. The expected damping forces for damped frame were first obtained based on storey shear forces; and then they were optimized to meet different storey drift requirements. A retrofit project of a RC frame school building damaged in the 2008 Wenchuan earthquake was introduced as a case study. This building was retrofitted by using viscous dampers designed through the simplified design procedure proposed in this paper. Based on the case study, it is concluded that this simplified design procedure can be effectively used to make seismic retrofit design of earthquake-damaged RC frames with viscous dampers, so as to achieve structural performance objectives under different earthquake risk levels.
A Distributed WebGIS Platform based on SaaS Architecture
Weng Yu,Xiaodong Jia,Yuan Jie 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.12
The emergence of cloud computing has changed the software development and deployment, providing users with great convenience. But even in the cloud computing environment, software development efficiency is particularly low. In order to improve the efficiency of software development, and make software release easier, we designed a layered service computing platform. With the help of basic services, the platform makes software development and publishing simple and efficient. To demonstrate our platform, we described the process of building a simple WebGIS system in this paper. This process represents the software development process in our platform. Experiment shows that our work is not only available but also simplifies the process of software development.