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Research on the Method of Fault Diagnosis Based on Multiple Classifiers Fusion
Yan Wen,Jiwen Tan,Hong Zhan,Hao Wang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.2
In traditional fault diagnosis method, a large number of experiments are needed to get the optimal performance classifier which diagnoses type of fault. Because of classifier algorithm limit, there is no one classifier can be applied to all kinds of fault diagnosis. In order to avoid the disadvantages caused by single classifier approach, decision level fusion method based on multiple classifiers fusion is introduced in the field of fault diagnosis. The fusion method with fuzzy comprehensive evaluation is put forward and the basic evaluation model is set up. The reasonable distribution of classifiers weight that affects diagnosis result directly is vital. Firstly, the evaluation function which measures member classifier’s diagnostic accuracy and correctness is constructed based on the theory of information entropy. Then, weights are distributed to each classifier with entropy coefficient according to the value of evaluation function. Experiments are carried out to demonstrate the effectiveness of the proposed method and results show that fault recognition rate after fusion is higher compared with the single classifier method.
( Wen Jing Yan ),( Ying Chun Tan ),( Ji Cheng Xu ),( Xian Ping Tang ),( Chong Zhang ),( Peng Bo Zhang ),( Ze Qiang Ren ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.3
Silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, has recently been identified as having antihepatotoxic and anticancer properties. In this paper, we investigated the effects of silibinin on behavior and neuroplasticity in mice subjected to chronic unpredictable mild stress (CUMS). After 5 consecutive weeks of CUMS, the mice were treated with silibinin (100 mg/kg, 200 mg/kg and 400 mg/kg by oral gavage) for 3 consecutive weeks. The results showed that silibinin administration significantly alleviated the CUMS-induced depressive-like behavior, including the total number of squares crossed and the frequency of rearing in the open field test, the immobility time in the tail suspension test and the forced swimming test. Furthermore, silibinin treatment increased the levels of brain-derived neurotrophic factor (BDNF), serotonin (5-HT) and norepinephrine (NE) in the prefrontal cortex and hippocampus. Our study provides new insight into the protective effects of silibinin on the depressive status of CUMS mice, specifically by improving neuroplasticity and neurotransmission.
( Wen Qian Wei ),( Fang Qi Liu ),( Lei Liu ),( Zuo Feng Li ),( Xiao Yan Zhang ),( Fan Jiang ),( Qu Shi ),( Xiao Yan Zhou ),( Wei Qi Sheng ),( San Jun Cai ),( Xuan Li ),( Ye Xu ),( Peng Nan ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.5
Hereditary non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant inheritance syndrome. HNPCC is the most common hereditary variant of colorectal cancer (CRC), which accounts for 2-5% CRCs, mainly due to hMLH1 and hMSH2 mutations that impair DNA repair functions. Our study aimed to identify the patterns of hMSH2 and hMLH1 mutations in Chinese HNPCC patients. Ninety-eight unrelated families from China meeting Amsterdam or Bethesda criteria were included in our study. Germline mutations in MLH1 and MSH2 genes, located in the exons and the splice-site junctions, were screened in the 98 probands by direct sequencing. Eleven mutations were found in ten patients (11%), with six in MLH1 (54.5%) and five in MSH2 (45.5%) genes. One patient had mutations in both MLH1 and MSH2 genes. Three novel mutations in MLH1 gene (c.157_160delGAGG, c.2157dupT and c.-64G>T) were found for the first time, and one suspected hotspot in MSH2 (c.1168C>T) was revealed. [BMB reports 2011; 44(5): 317-322]
Seismic collapse risk of RC frames with irregular distributed masonry infills
Yan-Wen Li,Michael C.H. Yam,Ke Cao 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.76 No.3
Masonry infills are normally considered as non-structural elements in design practice, therefore, the interaction between the bounding frame and the strength contribution of masonry infills is commonly ignored in the seismic analysis work of the RC frames. However, a number of typical RC frames with irregular distributed masonry infills have suffered from undesirable weak-story failure in major earthquakes, which indicates that ignoring the influence of masonry infills may cause great seismic collapse risk of RC frames. This paper presented the investigation on the risk of seismic collapse of RC frames with irregularly distributed masonry infills through a large number of nonlinear time history analyses (NTHAs). Based on the results of NTHAs, seismic fragility curves were developed for RC frames with various distribution patterns of masonry infills. It was found that the existence of masonry infills generally reduces the collapse risk of the RC frames under both frequent happened and very strong earthquakes, however, the severe irregular distribution of masonry infills, such as open ground story scenario, results in great risk of forming a weak story failure. The strong-column weak-beam (SCWB) ratio has been widely adopted in major seismic design codes to control the potential of weak story failures, where a SCWB ratio value about 1.2 is generally accepted as the lower limit. In this study, the effect of SCWB ratio on inter-story drift distribution was also parametrically investigated. It showed that improving the SCWB ratio of the RC frames with irregularly distributed masonry infills can reduce inter-story drift concentration index under earthquakes, therefore, prevent weak story failures. To achieve the same drift concentration index limit of the bare RC frame with SCWB ratio of about 1.2, which is specified in ACI318-14, the SCWB ratio of masonry-infilled RC frames should be no less than 1.5. For the open ground story scenario, this value can be as high as 1.8.
Antimicrobial glycoalkaloids from the tubers of Stephania succifera
Yan-Bo Zeng,Dai-Jing Wei,Wen-Hua Dong,Cai-Hong Cai,De-Lan Yang,Hui-Min Zhong,Wen-Li Mei,Hao Fu Dai 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.4
Three new glycoalkaloids, N-formyl-asimilobine-2-O-b-D-glucoside (1), (-)-1-O-b-D-glucoside-8-oxotetrahydropalmatine(2), and 1-N-monomethylcarbamateargentinine-3-O-b-D-glucoside (3) were isolated fromtubers of Stephania succifera. The structures were establishedbased on spectroscopic analysis, and the antimicrobialactivities of the three glycoalkaloids are reported.