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- 저자 : Wei Xing (검색결과 277 건)
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( Xing Wei Wang ),( Wei Wei ),( Wei Qiang Wang ),( Xiao Yan Zhao ),( Hong Guo ),( Dian Chun Fang ) 대한소화기학회 2014 Gut and Liver Vol.8 No.5
Background/Aims: To investigate the differential expression of RING finger (RNF) proteins in Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). Methods: The differential expression of RNFs in normal esophagus (NE), BE, and EAC was screened using microarray assay. Real-time quantitative polymerase chain reaction (PCR), tissue microarray assay, and Western blot analysis were independently performed to detect the mRNA and protein expression of screened RNFs. Results: The expression of nine RNFs in the BE or EAC was 2-fold higher than those in NE. Among these proteins, the RNF32 and RNF121 expression in BE was 20.3-fold and 16.4-fold higher, respectively, than that in NE, and the expression of RNF24, RNF130, RNF141, RNF139, RNF11, RNF14, and RNF159 was upregulated more than 2-fold compared with NE. The expression of nine RNFs was not only upregulated in the EAC but was also positively related to the RNF expression in BE. The PCR results also indicated increased expression of these RNFs in BE and EAC compared to NE. Furthermore, the mRNA expression of all RNFs, except for RNF141 in EAC, was dramatically higher than those in the BE. Similar results were also obtained from the Western blot analysis. Conclusions: A total of nine RNFs play critical roles in the progression of BE to EAC. (Gut Liver 2014;8:487-494)
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Xing-Wei Liang,Yong-Xun Jin,Ga-Young An,Seul-Ki Lee,Jung-Woo Kwon,Xiang-Shun Cui,Nam-Hyung Kim 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
It is well established that mitochondrial genome is strictly maternally inherited in mammalian, despite the fact that paternal mitochondria enter into oocyte during fertilization. To date, although some mechanisms have been extrapolated to interpret the elimination of paternal mitochondria, the exact mechanism still is unclear. Recent studies suggest that autophagy process and the ubiquitin-mediated degradation pathway may be involved in elimination of paternal mitochondria. However, the dynamic profiles of autophagy and ubiquitination associated with paternal mitochondria degradation have not been determined in mouse model. Through immunostaining with specific antibody LC3 and Ubiquitin and confocal microscopy, we investigated the dynamic profiles of LC3 and Ubiquitin signals in mouse embryos during preimplantation development. In addition, embryos were stained with MitoTracker Red for tracking the degradation process of paternal mitochondria. Our results showed that paternal mitochondria gradually degraded during postfertilization development, and sporadic paternal mitochondria were found at least in 16 cell embryos. LC3 and Ubiquitin signals appeared in the midpiece of sperm at 3 h postfertilization, and they were strictly colocalizated with paternal mitochondria from zygote to 2 cell embryo. Nevertheless, the colocalization became loose at 4 cell embryos, and gradually disappeared beyond 4 cell embryos. Our results confirmed that autophagy process and the ubiquitin-mediated degradation pathway may take part in the postfertilization remove of paternal mitochondria.
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Wei Han,Cong Zhang,Xiao-jiao Gao,Hua-bing Wang,Fang Chen,Fang Cao,Yong-wei Hu,Jun Ma,Xing Gu,Hou-zhong Ding 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1
Purpose: Five members of the zinc finger of the cerebellum (ZIC) family—ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5—have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled. ZIC proteins in 241 pairs of breast tumors and corresponding normal tissues were investigated using immunohistochemistry and the clinicopathologic roles of proteins were analyzed using Pearson’s chi-square test. Kaplan-Meier curves and Cox regression analysis were also used to analyze the prognostic value of the ZIC proteins. In addition, 12 pairs of fresh-frozen breast tumors and matched normal tissues were used in the western blotting analysis and RT-qPCR. Results: Only ZIC1 expression in normal tissues was obviously higher than that in tumors (p<0.001). On multivariate analysis, ZIC1 expression (in overall survival analysis: hazard ratio [HR], 0.405, 95% confidence interval [CI], 0.233–0.702, p=0.001; in disease-free survival analysis: HR, 0.395, 95% CI, 0.234–0.669, p=0.001) was identified as a prognostic indicator of invasive breast cancer. Conclusion: ZIC1, but not the other proteins, was obviously decreased in breast tumors and associated with clinicopathologic factors. Thus, ZIC1 might be a novel indicator to predict the overall and disease-free survival of invasive breast cancer patients.
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Wei Peng,Jie Liu,Wei Peng,Chenxu Li,Fuxing Zong,Wensi Xu,Xing Zhang 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.8
Heterogeneous catalysts with low cost, environmentally friendly, highly effective and ready separation from aqueous solution are highly desirable. Magnetic CuO-Fe3O4 nanoparticles, a type of non-toxic bimetallic transition metal oxide, is a promising heterogeneous catalyst for activation of peroxymonosulfate (PMS) to generate reactive oxygen species (ROS) that has not been previously investigated. In this study, the activation of PMS by CuO-Fe3O4 nanoparticles was evaluated using the degradation of 4-chlorophenol as a model reaction. Several critical factors such as pH, catalyst dosage and PMS concentration were investigated. CuO-Fe3O4/PMS system demonstrated a wide effective pH range to degrade 4-chlorophenol, namely 5.5 to 9.5. With the increase of the catalyst dosage, the degradation efficiency of 4-chlorophenol appeared to increase first and then decrease, that the inflection point was 0.5 g/L. Elevated PMS concentration obviously improved the decomposition of 4-chlorophenol; however, the plateau was reached when the PMS concentration was 8mM. Further increase in PMS concentration would not significantly improve the removal efficiency. Through examining the effects of scavengers and electron spin resonance (ESR) analyses, CuO-Fe3O4 nanoparticles were proven to activate PMS through a non-radical and radical pathway to generate singlet oxygen, sulfate radicals and hydroxyl radicals. Based on results, CuO-Fe3O4 nanoparticles were effective, environmentally friendly and low cost catalysts for efficient activation of PMS. These features make CuO-Fe3O4 nanoparticles a readily available heterogeneous catalyst to activate PMS for refractory organic pollutants degradation in advanced oxidation processes (AOPs).
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Xing, Wei Dong,Lee, Man Seung,Senanayake, Gamini Elsevier 2018 Hydrometallurgy Vol.180 No.-
<P><B>Abstract</B></P> <P>A separation process was developed to recover Au(III) from the chloride leach solution of anode slime using selective extraction and stripping step. The anode slime contained Ag, Au, Cu, Ni, Sn and Zn. The extraction with Cyanex 272 in kerosene was conducted by varying the HCl concentration of the solution from 0.5 to 9 M. Most of Au(III) and Sn(II) were extracted into Cyanex 272/kerosene phase together with a small amount of Cu(II) and Zn(II). The Au(III) in the loaded Cyanex 272 was selectively stripped over Sn(II) by (NH<SUB>4</SUB>)<SUB>2</SUB>S<SUB>2</SUB>O<SUB>3</SUB>. The McCabe-Thiele diagrams for the extraction and stripping were constructed. Extra pure Au(III) solution was recovered from the leach liquor by batch simulation experiments of two stage countercurrent extraction with Cyanex 272 and by one stage stripping with (NH<SUB>4</SUB>)<SUB>2</SUB>S<SUB>2</SUB>O<SUB>3</SUB>. The developed process can be applied to recover gold from a hydrochloric acid solution containing Ag(I), Cu(II), Sn(II) and Zn(II).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A process was developed to recover Au(III) from anode slime leaching solution. </LI> <LI> HCl concentration was varied from 0.5 to 9 M to investigate the separation behavior. </LI> <LI> Cyanex 272 selectively extracted Au(III) and Sn(II) over Cu(II), Zn(II), Ni(II) and Ag(I). </LI> <LI> Only Au(III) in the loaded Cyanex 272 was stripped by (NH<SUB>4</SUB>)<SUB>2</SUB>S<SUB>2</SUB>O<SUB>3</SUB>. </LI> <LI> The purity of Au(III) in stripping solution was higher than 99.9%. </LI> </UL> </P>
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Wei, Wan-Xing,Pan, Yuan-Jiang Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.11
1,12-diazacyclodocosane-2,11-dione was first isolated from a plant Phyllanthus niruri Linn. Its structure has been determined by means of spectroscopy methods and X-ray crystallography. Two peptide groups in the big ring (lactam) are the main factors influencing intermolecular contacts. The hydrogen-bond interaction of these hydrophilic groups is observed in the crystal structure. Meanwhile, C-H···O hydrogen bonds in molecules contribute to the formation of the whole crystal. These two kinds of hydrogen-bond form six- member rings among molecules. This compound crystallizes in the triclinic space group P-1 with a= 9.588(1) $\AA$, b= $9.850(1)\AA$, c = $11.810(1)\AA$, $\alpha=$ 68.18(1)$^{\circ}C$ , $\beta=$ 84.98(1), $\gamma$ = 86.03(1)$^{\circ}C$ , V = $1030.66(17)\AA3$ , Z = 2. A disorder of five-member carbon chain in the whole ring is observed in the title compound. The bond angle 105.8(4) is determined for a extreme configuration C(14)-C(15)-C(16), and 117.7(10) for another extreme configuration C(14')-C(15')-C(16'). In this crystal, two molecules are tied each other by short intermolecular hydrogen bonds, the oxygen atom being tied by hydrogen bond to nitrogen atom of another two molecules. The NMR and IR spectral data coincides to the structure of the compound.
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Xing, Wei Dong,Lee, Man Seung,Senanayake, Gamini Elsevier 2018 Hydrometallurgy Vol.180 No.-
<P><B>Abstract</B></P> <P>In Part 1 of this paper, gold(III) and Sn(II) were recovered from the chloride leach solution of anode slimes by extraction with Cyanex 272 and stripping with (NH<SUB>4</SUB>)<SUB>2</SUB>S<SUB>2</SUB>O<SUB>3</SUB> and NaOH solutions for gold(III) and Sn(II), sequentially. In this work, solvent extraction experiments were conducted to recover Ag(I) and Cu(II) from the Au(III) free raffinate containing Ni(II), Sn(II) and Zn(II) using two systems. In the first system, Cu(II) and Ag(I) were sequentially separated using LIX 63 and Alamine 336, respectively. Dilute HCl and NH<SUB>4</SUB>SCN were used as the stripping agents for Cu(II) and Ag(I), respectively. In the second system, Cyanex 301 co-extracted Ag(I), Cu(II) and Sn(II) from the Au(III) free raffinate. Aqua regia at different dilutions stripped these three metal ions from the loaded Cyanex 301. First, Cu(II) was selectively stripped from the loaded Cyanex 301 by employing ten times diluted aqua regia. Second, most of Ag(I) was selectively stripped over Sn(II) by five times diluted aqua regia. A process flowsheet for the separation and recovery of noble and base metals from the chloride leach solution of anode slime using extraction and stripping has been proposed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Au(III), Ag(I) and Cu(II) were recovered from the leach liquor of anode slime. </LI> <LI> Gold(III) was first separated by selective extraction with Cyanex 272. </LI> <LI> Cu(II) was then recovered by extraction with by LIX 63 and stripping with HCl solution. </LI> <LI> Extraction with Alamine 336 followed by stripping with NH<SUB>4</SUB>SCN led to Ag(I) solution. </LI> <LI> Both Cu(II) and Ag(I) was simultaneously extracted by Cyanex 301. </LI> </UL> </P>
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Distribution of shear force in perforated shear connectors
Xing Wei,M. Shariati,Y. Zandi,Shiling Pei,Zhibin Jin,S. Gharachurlu,M.M. Abdullahi,M.M. Tahir,M. Khorami 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.27 No.3
A perforated shear connector group is commonly used to transfer shear in steel–concrete composite structures when the traditional shear stud connection is not strong enough. The multi-hole perforated shear connector demonstrates a more complicated behavior than the single connector. The internal force distribution in a specific multi-hole perforated shear connector group has not been thoroughly studied. This study focuses on the load-carrying capacity and shear force distribution of multi-hole perforated shear connectors in steel.concrete composite structures. ANSYS is used to develop a three-dimensional finite element model to simulate the behavior of multi-hole perforated connectors. Material and geometric nonlinearities are considered in the model to identify the failure modes, ultimate strength, and load–slip behavior of the connection. A three-layer model is introduced and a closed-form solution for the shear force distribution is developed to facilitate design calculations. The shear force distribution curve of the multi-hole shear connector is catenary, and the efficiency coefficient must be considered in different limit states.
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