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Yoo, Ran Ji,Lee, Ji Woong,Lee, Kyo Chul,An, Gwang Il,Ko, In Ok,Chung, Wee Sup,Park, Ji Ae,Kim, Kyeong Min,Choi, Yang-Kyu,Kang, Joo Hyun,Lim, Sang Moo,Lee, Yong Jin 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2
$^{64}Cu$-labeled diacetyl-bis($N^4$-methylthiosemicarbazone) is a promising agent for internal radiation therapy and imaging of hypoxic tissues. In the study, we confirmed hypoxia regions in VX2 tumor implanted rabbits with injection $^{64}Cu$-ATSM and $^{18}F$-FDG using positron emission tomography (PET)/computed tomography (CT). PET images with $^{18}F$-FDG and $^{64}Cu$-ATSM were obtained for 40 min by dynamic scan and additional delayed PET images of $^{64}Cu$-ATSM the acquired up to 48 hours. Correlation between intratumoral $O_2$ level and $^{64}Cu$-ATSM PET image was analyzed. $^{64}Cu$-ATSM and $^{18}F$-FDG were intravenously co-injected and the tumor was dissected and cut into slices for a dual-tracer autoradiographic analysis. In the PET imaging, $^{64}Cu$-ATSM in VX2 tumors displayed a specific uptake in hypoxic region for48 h. The uptake pattern of $^{64}Cu$-ATSM in VX2 tumor at 24 and 48 h did not match to the $^{18}F$-FDG. Through ROI analysis, in the early phase (dynamic scan), $^{18}F$-FDG has positive correlation with $^{64}Cu$-ATSM but late phase (24 and 48 h) of the $^{64}Cu$-ATSM showed negative correlation with $^{18}F$-FDG. High uptake of $^{64}Cu$-ATSM in hypoxic region was responded with significant decrease of oxygen pressure, which confirmed by $^{64}Cu$-ATSM PET imaging and autoradiographic analysis. In conclusion, $^{64}Cu$-ATSM can utilize for specific targeting of hypoxic region in tumor, and discrimination between necrotic- and viable hypoxic tissue.
Neurofibromatosis Associated with Congenital Unilateral Pulsating Exophthalmos
Nam, Wee Hyun,Song, Poong Ho,Chung, Sang Sup,Lee, Chul Woo 慶北大學校 醫科大學 1971 慶北醫大誌 Vol.12 No.1
大部分의 搏動成 眼球突出은 眼窩內나 바로 眼窩後面 卽 海綿靜脈洞에 動靜脈吻合이 있을때 나타난다. 어떤 神經織維腫에서는 先天性 骨缺損이 頭??骨의 여러 部位에서 同伴될 수 있으며 特히 眼窩尖部骨組織의 缺損으로 側頭葉이 眼窩內로 脫出하여 腦壓으로 因한 搏動性 眼球窩出을 일으키는 機轉을 設明한 症例를 文獻上 볼 수 있다. 筆者는 蝶形骨 小翼 및 大翼의 缺損이 있고 搏動性眼球突出을 보이며 皮膚에 cafe-au-lait spots와 右側 上眼瞼, 側頭皮下 및 胴體에 神經織維腫을 가진 一例를 經驗하였기에 文獻考察과 함께 報告한다. A typical case of neurofibromatosis associated with congenital unilateral pulsating exophthalmos, which was verified roentgenologically, surgically and microscopically, has been reported and the literatures reviewed. The clinical and roentgenological findings were emphasized.
Neurofibromatosis associated with congenital unilateral pulsating exophthalmos
Nam, Wee Hyun,Song, Poong Ho,Chung, Sang Sup,Lee, Chul Woo 대한신경외과학회 1972 Journal of Korean neurosurgical society Vol.1 No.1
문헌상으로 선천적 박동성 안구돌출증을 동반하는 신경섬유종증의 보고례는 흔하지 않다. 저자는 15세 소녀에서 우측 안구돌출, 시력장애, 안검마비, 안검부종 등을 호소하는 예를 경험하였다. 초증은 2세때 소결절로 시작되어 점차 증대하여 지난 2년동안 악화하였다. 다발성으로 "Cafeau-lait"의 착색이 어릴 적부터 볼 수 있었다. 안구의 박동은 맥박과 일치하였으며 안구돌출은 18.5㎜이나 잡음은 청진할 수 없었다. 우측안구는 하방으로 전위되었으며 움직이지 않고 고정되어 있었다. X선상으로 우측 전두와는 파괴되었으며 비중격(Nasal septum)은 좌측으로 전위되어 있었으며 Sella turcica는 확대되어 있었다. 우측 개두술에서 측두부 안부조직이 심히 종창되어 있고 측두골은 심히 엷어져 있었으며 뇌경막은 비후되어 두개골에 유착되어 있었다. Sphenoidal bone은 파괴되어 없어졌으며 이 골결손부를 통하여 측우엽의 첨단이 안구 속으로 밀려 안구를 전하방으로 압박하고 있었다. 두개강내에 특유한 종양은 발견할 수 없었고 종창된 염부조직의 조직검사에서 신경섬유종을 발견할 수 있었다. 본례는 수술후 경과가 양호하여 퇴원하였다. 본증의 보고를 문헌 고찰과 아울러 기술하였다. A typical case of neurofibromatosis associated with congenital pulsating unilateral exophthalmos, which was verified roentgenologically, surgically and microscopically, has been reported and the literatures reviewed. The clinical and roentgenological findings were emphasized.
송인호 ( In Ho Song ),이태섭 ( Tae Sup Lee ),강주현 ( Joo Hyun Kang ),이용진 ( Yong Jin Lee ),김광일 ( Kwang Il Kim ),안광일 ( Gwang Il An ),정위섭 ( Wee Sup Chung ),천기정 ( Gi Jeong Cheon ),최창운 ( Chang Woon Choi ),임상무 ( Sa 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.5
목적: Hydrodynamic-based procedure는 손쉽고 간편한 비바이러스성 유전자 전달 방법으로 특히 간특이적으로 발현하는 특징을 가진다. 단순 헤르페스 바이러스 제 1 형 티미딘 키나제(herpes simplex virus type 1 thymidine kinase, HSV1-tk)와 다양한 기질을 이용한 비침습적 HSV1-tk 유전자 영상시스템이 널리 연구되어왔다. 본 연구에서는 HSV1-tk 유전자를 hydrodynamic-based procedure를 이용하여 전달한 후, HSV1-tk의 보고 기질로 알려진 5-(2-iodovinyl)-2`-deoxyuridine (IVDU)을 이용하여 간 특이적인 HSV1-tk 유전자 발현 영상을 획득하고자 하였다. 대상 및 방법: HSV1-tk 유전자와 녹색형광유전자를 가진 각 플라스미드 벡터를 마우스에 hydrodynaminc injection을 통해 전달하고, 24 시간 뒤 유전자의 발현을 확인하기 위해 RT-PCR, 생체형광영상, 핵의학영상, 전신자가방사영상 그리고 생체분포를 시행하였다. 결과: 각 플라스미드 벡터를 전달한 간으로부터 추출한 전체 RNA를 이용하여 RT-PCR을 수행한 결과, 각각 HSV1-tk 유전자와 녹색형광단백 유전자의 특이적인 밴드를 관찰할 수 있었다. 생체 분포 결과, pHSV1-tk 벡터를 전달한 마우스의 간에서 특이적인 [123I]IVDU의 섭취를 보였다. 생체형광영상에서는 pEGFP-N1 벡터를 전달한 마우스의 간에서는 유의한 형광신호를 나타내었다. 전신자가방사영상과 감마카메라 영상에서 pHSV1-tk 벡터를 전달한 마우스의 간에서 방사표지 IVDU가 국소적으로 집적되는 것을 확인하였다. 결론: 본 연구에서 hydrodynamic-based procedure는 간특이적으로 플라스미드 DNA를 전달하는데 효과적이며 전달된 유전자의 발현을 분자영상학적인 방법으로 확인하였다. 따라서 Hydrodynamic injection을 통해 HSV1-tk 유전자와 목적 유전자의 공동발현은 방사표지 IVDU에 의해 목적 유전자의 발현을 정량평가하는데 유용할 것으로 기대된다. Purpose: Hydrodynamic-based procedure is a simple and effective gene delivery method to lead a high gene expression in liver tissue. Non-invasive imaging reporter gene system has been used widely with herpes simplex virus type 1 thymidine kinase (HSV1-tk) and its various substrates. In the present study, we investigated to image the expression of HSV1-tk gene with 5-(2-iodovinyl)-2`-deoxyuridine (IVDU) in mouse liver by the hydrodynamic-based procedure. Materials and Methods: HSV1-tk or enhanced green fluorescence protein (EGFP) encoded plasmid DNA was transferred into the mouse liver by hydrodynaminc injection. At 24 h post-injection, RT-PCR, biodistribution, fluorescence imaging, nuclear imaging and digital wholebody autoradiography (DWBA) were performed to confirm transferred gene expression. Results: In RT-PCR assay using mRNA from the mouse liver, specific bands of HSV1-tk and EGFP gene were observed in HSV1-tk and EGFP expressing plasmid injected mouse, respectively. Higher uptake of radiolabeled IVDU was exhibited in liver of HSV1-tk gene transferred mouse by biodistribution study. In fluorescence imaging, the liver showed specific fluorescence signal in EGFP gene transferred mouse. Gamma-camera image and DWBA results showed that radiolabeled IVDU was accumulated in the liver of HSV1-tk gene transferred mouse. Conclusion: In this study, hydrodynamic-based procedure was effective in liver-specific gene delivery and it could be quantified with molecular imaging methods. Therefore, co-expression of HSV1-tk reporter gene and target gene by hydrodynamic-based procedure is expected to be a useful method for the evaluation of the target gene expression level with radiolabeled IVDU. (Nucl Med Mol Imaging 2009;43(5):468-477)
Benzoic Acid Enhances Embryo Implantation through LIF-Dependent Expression of Integrin αVβ3 and αVβ5
( Hee-jung Choi ),( Tae-wook Chung ),( Mi-ju Park ),( Hyung Sik Kim ),( Sooseong You ),( Myeong Soo Lee ),( Bo Sun Joo ),( Kyu Sup Lee ),( Keuk-jun Kim ),( Gabbine Wee ),( Choong-yong Kim ),( Cheorl-h 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.4
Embryo implantation is the crucial step for a successful pregnancy. Diverse factors, including adhesion molecules, growth factors, and cytokines are important for embryo implantation through improving endometrial receptivity. Benzoic acid (BA), a component of various plants, has been shown to have antifungal and antioxidant effects. However, the effect of BA on embryo implantation remains unknown. Here, we showed the contribution of BA for the enhancement of endometrial receptivity through the leukemia inhibitory factor (LIF)-dependent increase of integrin αV, β3, and β5 expression. Furthermore, in vivo study using a mifepristone-induced implantation failure model showed that BA definitely improves the numbers of implantation embryos. Taken together, we suggest that BA has a novel function for embryo implantation through the up-regulation of LIF-mediated integrins, and may be a candidate for therapeutic medicine to increase the pregnancy rate.
지방육종형성 동물모델에서 123I-15-(p-iodophenyl)-3-R , S-methylpentadecanoic acid ( BMIPP ) 의 생체분포와 생체영상
최창운(Chang Woon Choi),임상무(Sang Moo Lim),이태섭(Tae Sup Lee),서용섭(Yong Sup Suh),우광선,정위섭(Wee Sup Chung),임수정(Soo Jung Lim),오옥두(Ok Doo Awh) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.5
N/A Purpose: 123I-labeled fatty acids have been used in the evaluation of regional myocardial energy metabolism. This study aimed to evaluate the usefulness of 123I-BMIPP as a liposarcorna-imaging agent. Materials and Methods: We compared in vitro uptakes between liposarcoma(SW872) and glioma(9L) cell lines, and examined biodistribution and in vivo images of 123I-BMIPP in liposarcoma-bearing nude mice. Cold-BMIPP was labeled with 123I using Cu2+ as catalyst. After purification by Sep-pak, radiochemical purity was determined by TLC. We compared cellular uptake between glioma and liposarcoma after incubation of 5, 10, 15, 30, 60, 120, and 180 mins with culture medium containing I-BMIPP. The difference in biodistribution was determined between non-feeding (water only) group for 18 hr and feeding group in normal mice (n=6/group) at 0.5, 2, and 24 hr. In liposarcoma-bearing nude mice model, liposarcoma, SW872, cell lines were injected subcutaneously into the left thigh of nude mice. The biodistribution of 123I-BMIPP was evaluated at 0.5, 2, and 24 hr (n=5 / group) and in vivo image of 123I-BMIPP was obtained with gamma camera at 2 and 24 hr in liposarcorna-bearing nude mice. Results: Radiolabeling yield and radiochemical purity were 95% and above 99%, respectively. SW872 cell line showed more increased uptake than 9L with 1.5 times at 180 mins. The clearance of 'I-BMIPP in various tissues was more delayed in the non-feeding group than in the feeding group, especially at delayed time (24 hr) in normal mice, and the major excreting organ was the gastrointestinal tract. In liposarcoma-bearing nude mice, tumor/blood ratio of 123I-BMIPP was 0.94, 0.75, and 1.38 and tumor/muscle ratio was 0.66, 1.53, and 1.11 at 0.5, 2, and 24hr, respectively. 123I-BMIPP was selectively localized in liposarcoma at 24 hr image. Conclusions: These results suggest that 123I-BMIPP can be used as a liposarcoma-imaging agent. (Korean J Nucl Med 200135:324-333)