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Zhiming Wang,Qingyu Xu,Kaixin Chen 한국물리학회 2012 Current Applied Physics Vol.12 No.4
With Nd3þ doping and Ca2+, Sr2+ modulating in the solegel technique, a series of polycrystalline perovskite samples La0.7-xNdx(Ca,Sr)0.3MnO3 (x = 0, 0.05, 0.1, 0.15, 0.20, 0.25) was prepared, their maximum magnetic entropy changes were tuned to room temperature (ΔSH=-1.47 J/kg K at 298 K for La0.45Nd0.25(Ca,Sr)0.3MnO3), an enhancement of the maximum magnetic entropy change (ΔSH=-1.89 J/kg K at 315 K) and its refrigerant capacity (about 45.3 J/kg) had also been obtained under 9 kOe magnetic field variation for La0.55Nd0.15(Ca,Sr)0.3MnO3 contrast to La0.7(Ca,Sr)0.3MnO3.
QingLing Zhai,KaiXin Wang,Defu Zhang,Jinbo Chen,XiaoMeng Dong,Yonghui Pan 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.3
Background: Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this study was to investigate whether perampanel could exert an antimigraine effect. Methods: Nitroglycerin (NTG) was used to induce a migraine model in rats, and the model animals were pretreatment with 50 μg/kg and 100 μg/kg perampanel. The expression of pituitary adenylate-cyclase-activating polypeptide (PACAP) was quantified by western blot and quantitative real-time PCR in the trigeminal ganglion, and rat-specific enzyme-linked immunosorbent assay in serum. Western blot was also conducted to explore the effects of perampanel treatment on the phospholipase C (PLC)/protein kinase C (PKC) and protein kinase A (PKA)/ cAMP-responsive-element-binding protein (CREB) signaling pathways. Moreover, the cAMP/PKA/CREB-dependent mechanism was evaluated via in vitro stimulation of hippocampal neurons. The cells were treated with perampanel, antagonists and agonists for 24 hours and cell lysates were prepared for western blot analysis. Results: Perampanel treatment notably increased the mechanical withdrawal threshold and decreased head grooming and light-aversive behaviors in NTG-treated rats. It also decreased PACAP expression and affected cAMP/ PKA/CREB signaling pathway. However, PLC/PKC signaling pathway may not be involved in this treatment. In in vitro studies, perampanel notably decreased PACAP expression by inhibiting cAMP/PKA/CREB signaling pathway. Conclusions: This study shows that perampanel inhibits the migraine-like pain response and that this beneficial effect might be attributable to regulation of the cAMP/PKA/CREB signaling pathway.
Shuang Zhang,Yu Fang,Kaixin Shu,Qiuyang Gu,Xuehua Wang 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.12
A constant on-time variable frequency control (COTVFC) with feed-forward for a critical conduction mode (CRM) totempole power factor correction (PFC) converter is proposed in this paper. This control method only requires a single voltage loop, where the output is taken as the on-time of the main switches of the converter. The off-time of the main switches in different switching cycles is calculated by the voltage-second balance principle, which ensures that the converter always operates in the CRM. Feed-forward is introduced to improve the dynamic response of the converter. The control model is established and the transfer function from the on-time to the output is derived. On this basis, the control parameters of the voltage loop are designed. Then a simulation model is built in PSIM for simulation verification. Finally, a two-phase interleaved parallel GaN-based totem-pole PFC converter prototype is made for experimental verification. Simulation and experimental results verify the feasibility and effectiveness of the control method proposed in this paper.