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Wang Chenfei,Lu Jia,Sha Xudong,Qiu Yu,Chen Hongzhuan,Yu Zhihua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Although the ε4 allele of the apolipoprotein E (ApoE4) gene has been established as a genetic risk factor for many neurodegenerative diseases, including Alzheimer’s disease, the mechanism of action remains poorly understood. Transient receptor potential vanilloid 1 (TRPV1) was reported to regulate autophagy to protect against foam cell formation in atherosclerosis. Here, we show that ApoE4 leads to lipid metabolism dysregulation in microglia, resulting in enhanced MHC-II-dependent antigen presentation and T-cell activation. Lipid accumulation and inflammatory reactions were accelerated in microglia isolated from TRPV1flox/flox; Cx3cr1cre-ApoE4 mice. We showed that metabolic boosting by treatment with the TRPV1 agonist capsaicin rescued lipid metabolic impairments in ApoE4 neurons and defects in autophagy caused by disruption of the AKT-mTOR pathway. TRPV1 activation with capsaicin reversed ApoE4-induced microglial immune dysfunction and neuronal autophagy impairment. Capsaicin rescued memory impairment, tau pathology, and neuronal autophagy in ApoE4 mice. Activation of TRPV1 decreased microglial phagocytosis of synapses in ApoE4 mice. TRPV1 gene deficiency exacerbated recognition memory impairment and tau pathology in ApoE4 mice. Our study suggests that TRPV1 regulation of lipid metabolism could be a therapeutic approach to alleviate the consequences of the ApoE4 allele.
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Research on Preparation and Characteristics of a Novel Transmission Magnetorheological Fluid
Chen Fei,Tian Zuzhi,Wu Xiangfan,Wang Shuyou,Li Hao 한국자기학회 2018 Journal of Magnetics Vol.23 No.1
On the basis of orthogonal experiment, a novel transmission magnetorheological fluid with synthetic ester chain oil as carrier fluid is prepared. The effect of single additive content on the apparent viscosity and settling stability of magnetorheological fluid is analyzed, and the characteristic evaluations are also carried out. The results indicate that the magnetorheological fluid containing 60 wt% carbonyl iron powder has an apparent viscosity of 2.15 Pa·s and can attain the shear yield stress of 36 kPa when the magnetic field strength is 0.5T. Furthermore, the settlement rate of the MRF is less than 3% after two weeks. In comparison with the silicone oil and mineral oil, the synthetic ester chain oil-based magnetorheological fluid has the lowest thermal expansion rate.
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