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Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells
Lee, Jin-Hee,Kim, Sung-Su,Lee, Hun Seok,Hong, Sungyoul,Rajasekaran, Nirmal,Wang, Li-Hui,Choi, Joon-Seok,Shin, Young Kee Spandidos Publications 2017 International journal of oncology Vol.50 No.1
<P>SMAD4 is a tumor suppressor that is frequently inactivated in many types of cancer. The role of abnormal expression of SMAD4 has been reported in developmental processes and the progression of various human cancers. The expression level of SMAD4 has been related to the survival rate in gastric cancer patients. However, the molecular mechanism underlying transcriptional regulation of SMAD4 remains largely unknown. In the present study, we characterized the promoter region of SMAD4 and identified myeloid zinc finger 1 (MZF1), as a putative transcription factor. MZF1 directly bound to a core region of the SMAD4 promoter and stimulated transcriptional activity. We also found that the expression of MZF1 influences the migration ability of gastric adenocarcinoma cells. Collectively, our results showed that MZF1 has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZFl-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.</P>
Lee Wang hui,Ahn Sung min J-INSTITUTE 2018 International Journal of Crisis & Safety Vol.3 No.2
When measuring relative renal function ratio(RRFR) in nuclear medicine tests, radiation is usually counted us-ing a posterior detector. However, when there is a difference in the depth of the left and right kidneys, counting of the radiation using only the posterior detector may result in a lower counting rate of the deeply located kid-neys. In this study, we investigated the usefulness of geometric mean in measuring the RRFR by applying a geomet-ric mean after counting radiation using the anterior-posterior detector when the depths of the left and right kidneys are different. Kidney model studies and clinical studies were performed using the Symbia T16 gamma camera system to ob-tain anterior and posterior images. For RRFR calculations, RRFR was measured by applying arithmetic mean, once with information only counted by the posterior detector. Again, with the information counted by the ante-rior and posterior detectors, the geometric mean was applied to measure the RRFR. The results of the kidney model study were y = 0.23 + 0.38x, R2 = 0.986(p = 0.000), and the clinical results were y = 0.25 + 0.16x and R2 = 0.823(p = 0.000). It can be seen that as the depth difference of the elongation increases, the function ratio of the deeply located elongation increases gradually among the RRFRs in which the geometric mean is applied with the information counted by the anterior and posterior detectors. In kidney examinations conducted by the nuclear medicine department, the RRFR is generally measured using only the posterior detector. However, when the RRFR was measured using the geometric mean with the infor-mation from the anterior and posterior detectors, it was confirmed that the function ratio of the deeply located kidney rises. The above results suggest that the attenuation between the kidney and the detector is corrected. For patients with different depths of the left and right kidneys, it would be useful to measure the RRFR by apply-ing a geometric mean with the both detectors.
Wang, Manxiang,Liu, Guicheng,Yu, Hyunjin,Lee, Sang-Hyup,Wang, Lei,Zheng, Jianzhong,Wang, Tao,Yun, Yanbin,Lee, Joong Kee American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.16
<P>The vacuum membrane distillation (VMD) is a promising technology for lots of applications. To solve the membrane fouling and wetting problems, in this paper, a novel ZnO nanorods 1<I>H</I>,1<I>H</I>,2<I>H</I>,2<I>H</I>-perfluorodecyltriethoxysilane (PDTS) modified poly(vinylidene fluoride) (PVDF) membrane with a micro/nanoscale hierarchical structure and a superhydrophobic surface has been prepared and applied to the VMD process for distilling highly salty water, for the first time. Among these, a pyrolysis-adhesion method is created to obtain the ZnO seeds and fasten them on the PVDF substrate firmly. The novel modified membrane shows a stable superhydrophobic surface with a water contact angle of 152°, easy cleaning property, excellent thermal and mechanical stability, because of the Cassie’s state caused by pocketing much air in the hydrophobized ZnO nanorods, the low surface energy of PDTS coating, and the strong adhesion between ZnO nanorods and PVDF membrane, which has built an ideal structure for VMD application. After 8 h VMD of 200 g L<SUP>-1</SUP> NaCl solution, compared to the virgin PVDF membrane, the novel membrane shows a similar permeate flux but a much higher quality permeated liquid because of its unique antifouling and antiwetting caused by the several microns gap between the feed and the membrane. Due to its easy cleaning property, the novel membrane also exhibits an excellent reusability.</P> [FIG OMISSION]</BR>
Antiferroelectric Liquid Crystal from Bent-Core Molecule with Vinyl End Group
Lee, Chong-Kwang,Kwon, Soon-Sik,Kim, Tae-Sung,Shin, Sung-Tae,Choi, Hong,Choi, E. Joon,Kim, Sea-Yun,Zin, Wang-Choel,Kim, Dae-Choel,Chien, Liang-Chy Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.8
Three banana-shaped achiral compounds, 4-chloro-1,3-phenylene bis [4-{4-(undecenyloxy)phenyl imino-methyl} benzoate] derivatives, were synthesized with variation of a substituent (x=H, F, Cl); their antiferro-electric properties are described. The smectic mesophases, including a switchable chiral smectic C(Sm $C^{\ast}$) phase, were characterized by differential scanning calorimetry, polarizing optical microscopy, triangular wave method, and X-ray diffractometry. The presence of vinyl groups at the terminals of linear side wings in the banana-shaped achiral molecules induced a decrease in melting temperature and formation of the switchable Sm $C^{\ast}$ phase in the melt. The smectic phase having a lateral fluorine-substituent at 3-position of the Schiff's base moiety showed antiferroelctric switching, and the value of spontaneous polarization on reversal of an applied electric field was 250 nC/$cm^2$ .
Wang, Ai-Guo,Fang, Wan,Han, Ying-Hao,Cho, Sang-Mi,Choi, Jong Young,Lee, Kee Ho,Kim, Wook Hwan,Kim, Jin Man,Park, Moon Gi,Yu, Dae-Yeul,Kim, Nam-Soon,Lee, Dong-Seok The Korean Academy of Medical Sciences 2006 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.21 No.5
<P>Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In this study, RERG expression was analyzed in hepatocellular carcinomas of human patients using reverse transcriptase PCR analysis. In addition, the possible regulation of RERG expression by histone deacetyltransferases (HDACs) was studied in several cell lines. Interestingly, the expression of RERG gene was increased in hepatocellular carcinoma (HCC) of male patients (57.9%) but decreased in HCC of females (87.5%) comparison with paired peri-tumoral tissues. Moreover, RERG gene expression was increased in murine hepatoma Hepa1-6 cells, human breast tumor MDA-MB-231 cells, and mouse normal fibroblast NIH3T3 cells after treated by HDAC inhibitor, trichostatin A. Our results suggest that RERG may function in a gender-dependent manner in hepatic tumorigenesis and that the expression of this gene may be regulated by an HDAC-related signaling pathway.</P>
Lee, Hyojin,Ahn, Seung Il,Yang, Byung Wook,Park, Jong Dae,Shin, Wang Soo,Ko, Sung Kwon,Hahm, Young Tae The Korean Society for Microbiology and Biotechnol 2019 한국미생물·생명공학회지 Vol.47 No.2
Biotransformation of ginsenosides by microorganisms alters the absorption and bioavailability of ginseng as a medicinal herb. In this study, we isolated two kinds of fermenting microorganisms from Eoyukjang, which is a traditional Korean fermented food made from soybean. Next, we identified and detected their ability to convert major ginsenosides to compound K. The two microorganisms, referred to as R2-6 and R2-15, had 100% similarity with Lactobacillus plantarum subsp. plantarum ATCC $14917^T$ and Lactobacillus rhamnosus JCM $1136^T$, respectively. The optimal pH and growth temperature of the isolates were determined to be pH 6-7 and $30^{\circ}C$. After fermentation for 30 days, the major ginsenosides in the mountain-cultivated ginseng were transformed to the highly bioactive ginsenoside, compound K, in the final product.
Sang Min Lee,Joong San Wang,Sung Kyu Park,Hong Rae Kim,Jin Hee Ko,Yu Jung Oh,Hae Ran Yoon,Ji Sung Kim 국제물리치료학회 2012 Journal of International Academy of Physical Ther Vol.3 No.1
The aim of this study was to investigate the correlation among bone mineral density(BMD), body composition and body circumference on 20's college women in Hwaseong. A total of 86 subjects were measured with BMD and body composition and body circumference. To evaluate the correlation between BMD and body composition, bone density and body weight, body mass index(BMI), lean body mass, muscle mass, fat mass and body fat mass were compared. The results of this study, weight was considered the strong correlation with BMD than the height and BMI seems to be greater significance rather than the lumbar spine and femur BMD. In addition, the relationship between body composition and BMD, lean body mass, muscle mass, body fat mass were the most relevant factors and BMD. The relationship between BMD and body circumference that have been difficult because of not enough previous studies but somewhat the study showed that association.