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Highly porous 3D nanofiber scaffold using an electrospinning technique
Kim, GeunHyung,Kim, WanDoo Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of Biomedical Materials Research Part B Vol. No.
<P>A successful 3D tissue-engineering scaffold must have a highly porous structure and good mechanical stability. High porosity and optimally designed pore size provide structural space for cell accommodation and migration and enable the exchange of nutrients between the scaffold and environment. Poly(ε-carprolactone) fibers were electrospun using an auxiliary electrode and chemical blowing agent (BA), and characterized according to porosity, pore size, and their mechanical properties. We also investigated the effect of the BA on the electrospinning processability. The growth characteristic of human dermal fibroblasts cells cultured in the webs showed the good adhesion with the blown web relative to a normal electrospun mat. The blown nanofiber web had good tensile properties and high porosity compared to a typical electrospun nanofiber scaffold. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006</P>
다중노즐 전기방사공정을 이용한 PCL/HA 나노섬유 제작
김지웅(Jiwoong Kim),박종하(Jongha Park),윤현(Hyun Yoon),손준곤(Jungon Son),박고은(Koeun Park),박수아(Sua Park),김완두(Wandoo Kim) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
Electrospinning is the process using electrical charge to distort a pendant droplet of polymer solution into a fine fiber to be deposited onto a target substrate. The merits of electrospinning are the fiber fabrication of small diameter and good mechanical properties. This means the nanofiber formation with high surface area to volume ratio and the ability to control pore size. Nanometer-diameter nanofibers have the potential applications of filter membranes, biomedical device, wound dressing materials, artificial organs, nanoelectronics, nano-composites, and protective clothing. To fabricate the uniform thickness and oriented morphology of PCL/HA nanofiber, multi-nozzle spinnerets were manufactured with rotatable grounded target collector in this study. We measured SEM observation, mechanical property, and contact angle of PCL/HA nanofiber.
쾌속조형시스템을 이용한 생체 조직 재생용 지지체 제작과 특성분석
김지웅(Jiwoong Kim),박고은(Koeun Park),이준희(Jun-Hee Lee),박수아(Sua Park),김완두(Wandoo Kim) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
The purpose of tissue engineering is to repair or replace damaged tissues or organs by a combination of cells, scaffold, suitable biochemical and physio-chemical factors. Among the three components, the biodegradable scaffold plays an important role in cell attachment and migration. In this study, we designed 3D porous scaffold by Rapid Prototyping (RP) system and fabricated layer-by-layer 3D structure using Polycarprolactone (PCL) - one of the most flexible biodegradable polymer. Furthermore, the physical and mechanical properties of the scaffolds were evaluated by changing the pore size and the strand diameter of the scaffold. We changed nozzle diameter (strand diameter) and strand to strand distance (pore size) to find the effect on the mechanical property of the scaffold. And the surface morphology, inner structure and storage modulus of PCL scaffold were analyzed with SEM, Micro-CT and DMA.
Park, Su A.,Kim, Hyo Joo,Lee, Su Hee,Lee, Jun Hee,Kim, Hyung Keun,Yoon, Taek Rim,Kim, WanDoo Wiley Subscription Services, Inc., A Wiley Company 2011 Polymer engineering and science Vol.51 No.9
<P><B>Abstract</B></P><P>Tissue‐engineered scaffolds require an adequate three‐dimensional (3‐D) structure for cell growth and attachment. Solid freeform fabrication can provide the interconnected pore to induce the cell ingrowth, and electrospinning technique can make the nanofiber web with high surface for cell attachment. In this study, 3‐D polycaprolactone (PCL) scaffolds were fabricated using a rapid prototyping plotting system coupled with an electrospinning apparatus. Scanning electron micrographs showed that these hybrid scaffolds had a regular microfiber structure with interconnected pores and a nanofiber distribution appropriate for cell attachment. Scaffolds were seeded with MG63 cells for <I>in vitro</I> study and implanted in the tibia of rabbit for <I>in vivo</I> study. The resulting structure also facilitated cell adhesion, proliferation, and differentiation as evidenced by biochemical analyses and confocal microscopy. The hybrid scaffolds also exhibited good biocompatibility and osteoconductivity in animal studies. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers</P>
지승묵(Seungmuk Ji),김인영(Inyoung Kim),김은희(Eunhee Kim),정지은(Jieun Jung),김완두(Wandoo Kim),임현의(Hyuneui Lim) Korean Society for Precision Engineering 2012 한국정밀공학회지 Vol.29 No.1
We demonstrate the desert beetle back mimicking hybrid superhydrophilic/superhydrophobic patterned surface by using the combination method of colloidal lithography and gravure offset printing for nano and micro patterning, respectively. The two methods are cost-effective and industrially available techniques compared to the other nano/micro patterning methods. To verify the water collecting function of the hybrid surface, the water condensation behavior is investigated on the chilled surface in ambient temperature and high humidity. Due to the synergetic effect of drop and film wise condensation, the hybrid superhydrophobic/superhydrophilic surface shows the higher efficiency than one of single wettability surfaces. The work is underway to get the good patterns of hybrid surfaces for water collecting from the dew or fog.