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CHOI, SUNG KYUNG,HONG, SEONG HWI,KIM, HYUK SOON,SHIN, CHAN YOUNG,NAM, SUK WOO,CHOI, WAHN SOO,HAN, JEUNG-WHAN,YOU, JUENG SOO Spandidos Publications 2016 Oncology Reports Vol.35 No.2
<P>Bromodomain and extra-terminal domain (BET) family proteins are representative epigenetic modulators that read acetylated lysine residues and transfer cellular signals. Recently, the BET protein inhibitor JQ1 was developed and has been extensively studied in many cancer cell types. We demonstrated that JQ1 effectively suppressed the MYC-AP4 axis and induced antitumorigenic effects by targeting a bidirectional positive loop between MYC and AP4 which was first proposed in the present study. MYC and AP4 are the direct targets of BRD4, as demonstrated by chromatin immunoprecipitation (ChIP) assay and BRD4 loss-of-function experiments. Although inhibition of the MYC/MAC dimer suppressed AP4, the efficacy of suppression was not as effective as BRD4 inhibition. Notably, AP4 loss-of-function studies demonstrated that AP4 is a major critical target of JQ1 and that MYC is a novel downstream target of AP4, as demonstrated by AP4 binding to the MYC promoter. Taken together, our results suggest that the epigenetic reader BRD4 is a key mediator of the activated MYC-AP4 axis, which supports the possibility that targeting BET protein is a novel therapeutic strategy for MYC-AP4 axis-activated cancers.</P>
Choi, Yun-Hyeok,Yoo, Hee-Jung,Noh, Ill Chan,Lee, Jeong-Min,Park, Jae Won,Choi, Wahn Soo,Choi, Jung Ho 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5
The inhibition of Interleukin-1beta (IL-$1{\beta}$) is of substantial interest for the treatment of rheumatoid arthritis. Using an in vitro assay with RAW 264.7 cells, oxo-acetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester (1) was isolated from the roots of Paeonia suffruticosa Andrews as an inhibitor of IL-$1{\beta}$ with an $IC_{50}$ value of 56 ${\mu}M$. Compound 1 is a novel phenylesteric compound from P. suffruticosa Andrews. Compound 1 was shown to inhibit the production of pro-inflammatory cytokines in RAW 264.7 cells. Thus, a possible new action of novel compound is provided explaining the anti-rheumatoid arthritic properties of P. suffruticosa Andrews.
Identification of Nitric Oxide Synthase in Staphylococcus aureus
Choi, Wahn-Soo,Chang, Man-Sik,Han, Jeung-Whan,Hong, Sung-Youl,Lee, Hyang-Woo 성균관대학교 약학연구소 1997 成均藥硏論文集 Vol.9 No.1
The presence of nitric oxide synthase (NOS) in Staphylococcus aureus ATCC6538P was established by western blot analysis. The identity of citrulline formed from Larginine by the NOS was confirmed by both TLC and HPLC and the other product, No, by directly measuring the production of nitrogen oxides (NO_x) in the reaction mixture. The activity was inhibited by typical NOS inhibitors such as N-nitro-L-arginine methylester and N^G, N^G-dimethyl-L-arginine with the IC_50 of 4.9×10exp(-4) and 2.5×10exp(-4) M, respectively. The NOS activity was maximum at pH 6.5 and at 47.5℃. These results indicate that the NOS of S. aureus ATCC6538P is an isoform distinct from mammalian NOS.
Choi, Wahn Soo,Seo, Dong Wan,Chang, Man Sik,Han, Jeung Whan,Hong, Sung Youl,Paik, Woon Ki,Lee, Hyang Woo 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
The presence of L-arginine methylester (AME), L-arginine ethylester (AEE), or N-nitro-L-arginine methylester (NAME) in the growth media of Staphylococcus aureus increased the nitric oxide synthase (NOS) activity approximately 5-to 14-fold. The increase of NOS activity was confirmed by two assay methods, namely assaying the formation of L-[^3H] citrulline from L-[^3H] arginine and NO formation. The increase of NOS activity was most likely due to increased de novo synthesis, demonstrated by Western immunoblot analysis. The addition of methanol to the culture medium also increased the NOS activity as much as that found with the above three compounds. Evidence is presented to show that AME, AEE, or NAME gave rise to the formation of methanol in vivo by the action of intracellular esterase(s) and that methanol is subsequently involved in the induction of NOS in this bacterial system.
A Turbidimetric Determination of Protein by Trichloroacetic Acid
Choi, Wahn-Soo,Chung, Kae-Jong,Chang, Man-Sik,Chun, Jae-Kwang,Lee, Hyang-Woo,Hong, Sung-Youl The Pharmaceutical Society of Korea 1993 Archives of Pharmacal Research Vol.16 No.1
Based on the turbidimetric response of protein with 50% trichloroacetic acid (TCA), this study aims to introduce an assay method for protein in solution. The standard procedure consists of mixing equal volume of sample solution (standard or unknown) with 50%-TCA solution and measuring the absorbance at 450 nm after 20 min. The absorbances of the solutions were almost stable over 120 min at room temperature. This assy method is simple, reproducible, and tolerant to many interfering substances. It can detect less amount than $10\mu$g/ml of bovin serum albumin. The assay method has low protein-to-protein variability over wide range of molecular weight.
Choi, Ji Na,Choi, Yun-Hyeok,Lee, Jeong-Min,Noh, Ill Chan,Park, Jae Won,Choi, Wahn Soo,Choi, Jung Ho Taylor Francis Health Sciences 2012 NATURAL PRODUCT RESEARCH Vol.26 No.24
<P>Trachelospermum jasminoides (Apocynaceae) has pharmacological effects that include anti-inflammatory, anti-bacterial and anti-viral activities, which have been observed from various studies. Of these pharmacological effects, the anti-inflammatory capacity of compounds from T. jasminoides is not yet known exactly. In this study, we investigated the compound that can be used for the suppression of lipopolysacchaide (LPS) stimulated inflammatory responses in macrophages among the five isolated compounds. β-sitosterol-β-D-glucoside (1) was found to reduce nitric oxide (NO) production from LPS-induced RAW 264.7 cells the most. In addition, compound 1 strongly inhibited the interleukin 6 (IL-6) activities of stimulated macrophages. Treatment of RAW 264.7 cells with compound 1 reduced secretion of inflammatory elements including tumour necrosis factor - alpha (TNF-α) and interleukin 1 beta (IL-1β). Thus, compound 1 may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.</P>
Choi, Se-Young,Choi, Dong-Kug,Park, Pyo-Jam,Choi, Wahn-Soo,Kim, Jong-Dai,Shin, Heung-Mook,Lim, Beong-Ou The Korean Society of Medicinal Crop Science 2007 韓國藥用作物學會誌 Vol.15 No.2
Inhibitory effect of Scutellaria baicalensis ethanol extracts (SR) on chemical mediator release and immunoglobulin (Ig) production from Sprague-Dawley rats originated cells as type I allergic reaction was examined. SR showed concentration-dependent inhibition on basal and concanavalin A (ConA)-stimulated Ig production. In the mesenteric lymph node lymphocytes, the inhibitory effect of SR on the IgE production in the presence of Con A was stronger than these on IgA and IgG production. Moreover, tumor necrosis factor-alpha $(TNF-{\alpha})$ production-inhibiting effect of SR in the presence ConA was observed. However, SR did not affect the production of $interferon-{\gamma}$. SR also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore A23187. In the case of leukotriene B4, SR markedly inhibited it at the concentration of 100 mg/ml. From these results, ethanol extracts obtained from Scutellaria baicalensis may have an anti-allergic effect on the intestinal system of rats.
최완수(Wahn Soo Choi),정계종(Kae Jong Chung),이주경(Joo Kyung Lee),박주웅(Joo Woong Park),이상훈(Sang Hoon Lee),이진복(Jin Bok Lee),이송락(Song Rag Lee),최신원(Shin Won Choi) 대한약학회 1993 약학회지 Vol.37 No.2
Serratia sp. Y-4 was isolated from soil. Many characteristics of the strain and optimum cultivation condition for protease production were investigated. The protease from Serratia sp. Y-4 was purified and studied for the properties of the enzyme. The isolated strain was identified to the genus Serratia. The strain was cultivated in 1%-casein, 0.5%-Na3PO4.7H2O, 0.1%-NaCl, 0.05%-KCl, 0.02%-MgSO4.7H2O, 0.02%-CaCl2.2H2O, 0.02%-ZnSO4.7H2O, 0.02%-MnCl2.4H2O and 0.5%-soy bean oil at pH 7.0 for 35 hrs. The enzyme was purified about 5.89 fold from the culture broth with 31.1% recovery and 19,613mc/mg through ultrafiltration, ammonium sulfate, DEAE-sephacel and Superose-12 chromatography. The purified enzyme was identified as one band by isoelectric focusing, SDS- and native-PAGE. It has maxium activity at 37oC and pH 9.0. Molecular weight of it is approx. 50 kD and pI is about 6.70. Its Km value for casein was 20mg/ml. 5 mM-EDTA, 5 mM-SDS, Ag+1, Cu+2, Hg+2 and Pb+2 inhibited the enzyme.
Se-Young Choi,Dong-Kug Choi,Pyo-Jam Park,Wahn-Soo Choi,Jong-Dai Kim,Heung-Mook Shin,Beong-Ou Lim 한국약용작물학회 2007 한국약용작물학회지 Vol.15 No.2
Inhibitory effect of Scutellaria baicalensis ethanol extracts (SR) on chemical mediator release and immunoglobulin (Ig) production from Sprague-Dawley rats originated cells as type I allergic reaction was examined. SR showed concentration-dependent inhibition on basal and concanavalin A (ConA)-stimulated Ig production. In the mesenteric lymph node lymphocytes, the inhibitory effect of SR on the IgE production in the presence of Con A was stronger than these on IgA and IgG production. Moreover, tumor necrosis factor-alpha (TNF-α) production-inhibiting effect of SR in the presence ConA was observed. However, SR did not affect the production of interferon-γ. SR also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore A23187. In the case of leukotriene B4, SR markedly inhibited it at the concentration of 100 mg/ml. From these results, ethanol extracts obtained from Scutellaria baicalensis may have an anti-allergic effect on the intestinal system of rats.