중국 유학생의 유학생활 만족도와 인터넷 중독에 관한 연구

부문문(Fu, Wen Wen),김민정(Kim, Min Jeong) 한국생활과학회 2014 한국생활과학회지 Vol.23 No.3

Analysis of dynamic behavior for truss cable structures

Wen-Fu Zhang,Ying-Chun Liu,Jing Ji,Zhen-Chao Teng 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.16 No.2

Natural vibration of truss cable structures is analyzed based upon the general structural analysis software ANSYS, energy variational method and Rayleigh method, the calculated results of three methods are compared, from which the characteristics of free-vibration are obtained. Moreover, vertical seismic response analysis of truss cable structures is carried out via time-history method. Introducing three natural earthquake waves calculated the results including time-history curve of vertical maximal displacement, time-history curve of maximal internal force. Variation curve of maximal displacement of node along span, and variation curve of maximal internal force of member along span are presented. The results show the formulas of frequencies for truss cable structures obtained by energy variational method are of high accuracy. Furthermore, the maximal displacement and the maximal internal force occur near the 1/5 span point. These provide convenient and simple design method for practical engineering.

Genomic Screening for Targets Regulated by Berberine in Breast Cancer Cells

Wen, Chun-Jie,Wu, Lan-Xiang,Fu, Li-Juan,Yu, Jing,Zhang, Yi-Wen,Zhang, Xue,Zhou, Hong-Hao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Berberine, a common isoquinoline alkaloid, has been shown to possess anti-cancer activities. However, the underlying molecular mechanisms are still not completely understood. In the current study, we investigated the effects of berberine on cell growth, colony formation, cell cycle distribution, and whether it improved the anticancer efficiency of cisplatin and doxorubicin in human breast cancer estrogen receptor positive (ER+) MCF-7 cells and estrogen receptor negative (ER-) MDA-MB-231 cells. Notably, berberine treatment significantly inhibited cell growth and colony formation in the two cell lines, berberine in combination with cisplatin exerting synergistic growth inhibitory effects. Accompanied by decreased growth, berberine induced G1 phase arrest in MCF-7 but not MDA-MB-231 cells. To provide a more detailed understanding of the mechanisms of action of berberine, we performed genome-wide expression profiling of berberine-treated cells using cDNA microarrays. This revealed that there were 3,397 and 2,706 genes regulated by berberine in MCF-7 and MDA-MB-231 cells, respectively. Fene oncology (GO) analysis identified that many of the target genes were involved in regulation of the cell cycle, cell migration, apoptosis, and drug responses. To confirm the microarray data, qPCR analysis was conducted for 10 selected genes based on previously reported associations with breast cancer and GO analysis. In conclusion, berberine exhibits inhibitory effects on breast cancer cells proliferation, which is likely mediated by alteration of gene expression profiles.

Preferential Induction of CYP1A1 over CYP1B1 in Human Breast Cancer MCF-7 Cells after Exposure to Berberine

Wen, Chun-Jie,Wu, Lan-Xiang,Fu, Li-Juan,Shen, Dong-Ya,Zhang, Xue,Zhang, Yi-Wen,Yu, Jing,Zhou, Hong-Hao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Estrogens are considered the major breast cancer risk factor, and the carcinogenic potential of estrogens might be attributed to DNA modification caused by derivatives formed during metabolism. $17{\beta}$-estradiol ($E_2$), the main steroidal estrogen present in women, is metabolized via two major pathways: formation of 2-hydroxyestradiol (2-OH $E_2$) and 4-hydroxyestradiol ($4-OH\;E_2$) through the action of cytochrome P450 (CYP) 1A1 and 1B1, respectively. Previous reports suggested that $2-OH\;E_2$ has putative protective effects, while $4-OH\;E_2$ is genotoxic and has potent carcinogenic activity. Thus, the ratio of $2-OH\;E_2/4-OH\;E_2$ is a critical determinant of the toxicity of $E_2$ in mammary cells. In the present study, we investigated the effects of berberine on the expression profile of the estrogen metabolizing enzymes CYP1A1 and CYP1B1 in breast cancer MCF-7 cells. Berberine treatment produced significant induction of both forms at the level of mRNA expression, but with increased doses produced 16~ to 52~fold greater induction of CYP1A1 mRNA over CYP1B1 mRNA. Furthermore, berberine dramatically increased CYP1A1 protein levels but did not influence CYP1B1 protein levels in MCF-7 cells. In conclusion, we present the first report to show that berberine may provide protection against breast cancer by altering the ratio of CYP1A1/CYP1B1, could redirect $E_2$ metabolism in a more protective pathway in breast cancer MCF-7 cells.

TCP/IP 통신을 이용한 원거리 힘 피드백 시스템 제어

Wen Fan Fu,이언주(Eon Joo Lee),최재원(Jae Weon Choi) 제어로봇시스템학회 2023 제어·로봇·시스템학회 논문지 Vol.29 No.2

Lateral-torsional Buckling Analysis of Cantilever Beam with Tip Lateral Elastic Brace under Uniform and Concentrated Load

Wen-Fu Zhang,Ying-Chun Liu,Gui-Lan Hou,Ke-Shan Chen,Jing Ji,Yun Deng,Shi-Lin Deng 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4

The studies on the lateral-torsional buckling of cantilever steel beam with tip lateral elastic brace are rarely reported. The total potential energy is first established for the lateral-torsional buckling of cantilever steel beam with tip lateral elastic brace under uniform and concentrated load. The modal trial function of the lateral displacement and torsional angle are expressed as trigonometric function combination with six terms. By introducing new dimensionless parameters, the analytical solution of the dimensionless buckling equation for the lateral-torsional buckling of cantilever steel beam with tip lateral elastic brace is obtained. With the help of 1stOpt software which is mathematical optimization analysis software, the non-dimensional critical moment formula of the lateral-torsional buckling of cantilever beam with tip lateral elastic brace is obtained. Then, the accuracy of the formula is verified by ADINA finite element software. The results show that the given critical moment formula is of high accuracy. It provides convenient and simple design method for practical engineering.

A FACILE ONE-STEP HYDROTHERMAL METHOD TO PRODUCE GRAPHENE OXIDE/Fe2O3-NANOTUBES COMPOSITES AND ITS ELECTROCHEMICAL PROPERTIES

WEN FU,CHUNNIAN CHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.4

The composites of graphene oxide/Fe2O3-nanotubes (GO/Fe2O3-NTs) have been fabricated through a facile one-step hydrothermal method. Fe2O3-NTs crystallines were homogeneously distributed on GO, which have been con¯rmed by transmission electron microscopy analysis (TEM). The structure, composition and electrochemical properties of GO/Fe2O3-NTs composites were investigated by means of selective-area electron di®raction (SAED), Fourier transform infrared spectroscopy (FT-IR), X-ray di®raction (XRD), Raman spectra, cyclic voltammogram (CV) curves and galvanostatic charge?discharge curves. GO/Fe2O3-NTs composites exhibit a high speci¯c capacitance of 133.2 Fg?1 in 1M Li2SO4 electrolyte. In addition, the GO/Fe2O3-NTs composites electrode shows good long-term cycle stability (only 9% decrease of the speci¯c capacitance is observed after 1000 charge?discharge cycles).

The Feasibility of Establishing Color Imagery Scales for Various Constructional Landscapes

Wen-Guey Kuo,Yu-Pin Li,Yuh-Chang Wei,Chih-Wen Cheng,Wei-Min Fu 한국색채학회 2017 AIC 2017 Jeju Vol.2017 No.10

A methodology of quantifying the environmental color imagery of color images of constructional landscapes individually was created in this study based on the new color imagery scales designed with combining a modified psychophysical method, Magnitude Estimation Method celebrated in the field of color science and the semantic differential method proposed by Osgood. The color imageries of the cumulated constructional landscape-image samples respectively were further estimated under a conditioned room using the creative experimental methodology. Meanwhile, a set of new environmental color imagery scales LEB were derived from the experimental results, and would be expected to raise the feasibility of computerized prediction in color imagery for the practical environment at speed during the field trial in the near future.

Development of Novel Pineapple Peel Juice Through Lactic Acid Fermentation for Enhancing Antioxidant Capacity and Stability

( Wen Fu Wu ),( Yi Ching Liu ),( Hsin Yun Chang ),( Chen Wei Huang ),( Ying Chen Lu ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

Pineapples are tropical fruit that are rich in vitamins, enzymes and fibers with many health benefits not only in pulps but also peels. However, the peels of pineapples are normally removed and dropped. The pulps and peels of four pineapple cultivars, Milk, Honey Fragrance, Smooth Cayenne and Golden Diamond pineapples, were juiced, filtered and analyzed, and the Golden Diamond pineapple was found to have highest antioxidant capacity. The pulp and peel juices of Golden Diamond pineapple were inoculated with Enterococcus faecium LYC91 and various concentration calcium carbonate to ferment at 37°C for 24 hours follow by bacterial and antioxidant capacity analysis. The results indicated that the fermented pineapple peel juice with calcium carbonate had highest bacterial number, total polyphenol content, DPPH radical scavenging ability, Fe2 + chelating ability and reducing power activity than pulp juice and unfermented pineapple juice. The viable bacterial number of fermented pineapple pulp and peel juices with calcium carbonate remain 8.0 log CFU/mL after stored at 4°C for 1 month. The freeze-dried powder of the fermented pineapple pulp and peel juices with calcium carbonate retained the viable cell number of 9.0 log CFU/g after stored at 4°C for three months. These results showed that the fermented pineapple pulp and peel juices with calcium carbonate were novel pineapple lactic acid fermented drinks with growth potential.

Analytical Solutions for the Inelastic Lateral-Torsional Buckling of I-Beams Under Pure Bending via Plate-Beam Theory

Wen-Fu Zhang,Leroy Gardner,M. Ahmer Wadee,Minghao Zhang 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.4

The Wagner coeffi cient is a key parameter used to describe the inelastic lateral-torsional buckling (LTB) behaviour of the I-beam, since even for a doubly-symmetric I-section with residual stress, it becomes a monosymmetric I-section due to the characteristics of the non-symmetrical distribution of plastic regions. However, so far no theoretical derivation on the energy equation and Wagner’s coeffi cient have been presented due to the limitation of Vlasov’s buckling theory. In order to simplify the nonlinear analysis and calculation, this paper presents a simplifi ed mechanical model and an analytical solution for doubly-symmetric I-beams under pure bending, in which residual stresses and yielding are taken into account. According to the plate-beam theory proposed by the lead author, the energy equation for the inelastic LTB of an I-beam is derived in detail, using only the Euler–Bernoulli beam model and the Kirchhoff -plate model. In this derivation, the concept of the instantaneous shear centre is used and its position can be determined naturally by the condition that the coeffi cient of the cross-term in the strain energy should be zero; formulae for both the critical moment and the corresponding critical beam length are proposed based upon the analytical buckling equation. An analytical formula of the Wagner coeffi cient is obtained and the validity of Wagner hypothesis is reconfi rmed. Finally, the accuracy of the analytical solution is verifi ed by a FEM solution based upon a bi-modulus model of I-beams. It is found that the critical moments given by the analytical solution almost is identical to those given by Trahair’s formulae, and hence the analytical solution can be used as a benchmark to verify the results obtained by other numerical algorithms for inelastic LTB behaviour.