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RISS 인기검색어
- 검색키워드
- 저자 : Visagie, C.M. (검색결과 3 건)
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Identification and nomenclature of the genus <i>Penicillium</i>
Visagie, C.M.,Houbraken, J.,Frisvad, J.C.,Hong, S.-B.,Klaassen, C.H.W.,Perrone, G.,Seifert, K.A.,Varga, J.,Yaguchi, T.,Samson, R.A. CBS PUBLICATIONS 2014 STUDIES IN MYCOLOGY Vol.78 No.-
<P><I>Penicillium</I> is a diverse genus occurring worldwide and its species play important roles as decomposers of organic materials and cause destructive rots in the food industry where they produce a wide range of mycotoxins. Other species are considered enzyme factories or are common indoor air allergens. Although DNA sequences are essential for robust identification of <I>Penicillium</I> species, there is currently no comprehensive, verified reference database for the genus. To coincide with the move to one fungus one name in the International Code of Nomenclature for algae, fungi and plants, the generic concept of <I>Penicillium</I> was re-defined to accommodate species from other genera, such as <I>Chromocleista</I>, <I>Eladia</I>, <I>Eupenicillium</I>, <I>Torulomyces</I> and <I>Thysanophora</I>, which together comprise a large monophyletic clade. As a result of this, and the many new species described in recent years, it was necessary to update the list of accepted species in <I>Penicillium</I>. The genus currently contains 354 accepted species, including new combinations for <I>Aspergillus crystallinus</I>, <I>A. malodoratus</I> and <I>A. paradoxus</I>, which belong to <I>Penicillium</I> section <I>Paradoxa</I>. To add to the taxonomic value of the list, we also provide information on each accepted species MycoBank number, living ex-type strains and provide GenBank accession numbers to ITS, β-tubulin, calmodulin and <I>RPB2</I> sequences, thereby supplying a verified set of sequences for each species of the genus. In addition to the nomenclatural list, we recommend a standard working method for species descriptions and identifications to be adopted by laboratories working on this genus.</P>
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Phylogeny, identification and nomenclature of the genus Aspergillus
Samson, R.A.,Visagie, C.M.,Houbraken, J.,Hong, S.B.,Hubka, V.,Klaassen, C.H.W.,Perrone, G.,Seifert, K.A.,Susca, A.,Tanney, J.B.,Varga, J.,Kocsube, S.,Szigeti, G.,Yaguchi, T.,Frisvad, J.C. Centraalbureau voor Schimmelcultures 2014 Studies in mycology Vol.78 No.-
Aspergillus comprises a diverse group of species based on morphological, physiological and phylogenetic characters, which significantly impact biotechnology, food production, indoor environments and human health. Aspergillus was traditionally associated with nine teleomorph genera, but phylogenetic data suggest that together with genera such as Polypaecilum, Phialosimplex, Dichotomomyces and Cristaspora, Aspergillus forms a monophyletic clade closely related to Penicillium. Changes in the International Code of Nomenclature for algae, fungi and plants resulted in the move to one name per species, meaning that a decision had to be made whether to keep Aspergillus as one big genus or to split it into several smaller genera. The International Commission of Penicillium and Aspergillus decided to keep Aspergillus instead of using smaller genera. In this paper, we present the arguments for this decision. We introduce new combinations for accepted species presently lacking an Aspergillus name and provide an updated accepted species list for the genus, now containing 339 species. To add to the scientific value of the list, we include information about living ex-type culture collection numbers and GenBank accession numbers for available representative ITS, calmodulin, β-tubulin and RPB2 sequences. In addition, we recommend a standard working technique for Aspergillus and propose calmodulin as a secondary identification marker.
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Warburg effect and its role in tumourigenesis
Maphuti T. Lebelo,Anna M. Joubert,Michelle H. Visagie 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.10
Glucose is a crucial molecule in energy productionand produces different end products in non-tumourigenic-and tumourigenic tissue metabolism. Tumourigeniccells oxidise glucose by fermentation and generate lactateand adenosine triphosphate even in the presence of oxygen(Warburg effect). The Na+/H+-antiporter is upregulated intumourigenic cells resulting in release of lactate- and H+ions into the extracellular space. Accumulation of lactateandproton ions in the extracellular space results in an acidicenvironment that promotes invasion and metastasis. OttoWarburg reported that tumourigenic cells have defectivemitochondria that produce less energy. However, decadeslater it became evident that these mitochondria have adaptedwith alterations in mitochondrial content, structure, functionand activity. Mitochondrial biogenesis and mitophagyregulate the formation of new mitochondria and degradationof defective mitochondria in order to combat accumulationof mutagenic mitochondrial deoxyribonucleic acid. Tumourigenic cells also produce increase reactive oxygenspecies (ROS) resulting from upregulated glycolysis leadingto pathogenesis including cancer. Moderate ROS levelsexert proliferative- and prosurvival signaling, while highROS quantities induce cell death. Understanding the crosstalkbetween aberrant metabolism, redox regulation, mitochondrialadaptions and pH regulation provides scientificandmedical communities with new opportunities to explorecancer therapies.
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