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Salvatrione : A Diterpene-monoterpene Conjugate from Salvia bucharica
Viqar Uddin Ahmad,Muhammad Zahid,Muhammad Shaiq Ali,Amir Reza Jassbi,Shakeel Ahmad,Zulfiqar Ali,Muhammad Zafar Iqbal 한국생약학회 2000 Natural Product Sciences Vol.6 No.2
Salvia bucharica belonging to the family Lamiaceae (Labiatae), afforded a novel terpenoid (1) named as salvatrione. The structure of 1 was elucidated through extensive 2-D NMR experiments and the biogenetic pathway of 1 has also been proposed. On biogenetic grounds, 1 may be considered to be a pseudo-triterpenoid as it is derived from the coupling of mono/diterpenic units and not from squalene.
Two New Sesquiterpenes from Pluchea arguta
Viqar Uddin Ahmad,Muhammad Zahid,Rasheeda Khatoon,Zulfiqar Ali,Muhammad Abbas,Muhammad Zafar Iqbal 한국생약학회 1999 Natural Product Sciences Vol.5 No.2
Two new sesquiterpenes, 3`-chloro-2`-hydroxy-3-epi-arguticinin (1) and argutenol (2) belonging to eudesmane and gorgonane classes respectively, have been isolated from Pluchea arguta. Their structures were elucidated with the help of sophisticated spectroscopic techniques including nOe difference and NOESY experiments.
Chemical Constituents of Pulicaria gnaphalodes
Muhammad Shaiq Ali,Muhammad Jahangir,Muhammad Saleem,Viqar Uddin Ahmad 한국생약학회 1999 Natural Product Sciences Vol.5 No.3
The chloroform extract of Pulicaria gnaphalodes yielded flavonoids (1-2), sesquiterpenoid (3), sterol (4), benzoic acid derivative (5) and fatty acids (6-7). Their structures were elucidated with the aid of NMR spectroscopy. The described compounds have not been reported so far from this source.
Abdul Jabbar Shah,Anwarul-Hassan Gilani,Kanza Abbas,Munawwer Rasheed,Amir Ahmed,Viqar Uddin Ahmad 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8
This study describes the chemical composition of the essential oil of Artemisia maritima (Am.Oil) and the pharmacological basis for its medicinal use in gut and airways disorders. Twenty five compounds, composing 93.7% of the oil, were identified; among these, chrysanthenyl propionate and elixene were identified for the first time from any Artemisia species. The Am.Oil (0.3-1.0 mg/mL) suppressed spontaneous and high K^+ (80 mM)-induced contractions in isolated rabbit jejunum, suggestive of an antispasmodic effect mediated possibly through calcium channel blockade. The calcium channel blockade activity was confirmed when pre-treatment of the tissue with Am.Oil (0.01-0.03 mg/mL) shifted the Ca^++ concentration-response curves to the right, similar to verapamil and papaverine. In isolated tracheal strips, Am.Oil inhibited carbachol (CCh; 1 μM)-induced contractions more than that induced by K^+ and shifted the isoprenaline-induced inhibitory CRCs to the left, similar to papaverine, suggestive of potentiation, while, verapamil was more potent against K^+ than CCh-induced contractions and had no potentiating effect on isoprenaline-induced inhibitory CRCs. These data indicate that the Am.Oil exhibited spasmolytic and bronchodilator activities mediated possibly through dual blockade of calcium channels and phosphodiesterase, which provides the pharmacological basis to the medicinal use of Artemisia maritima in colic, diarrhea and possibly asthma.
Metabolites of Marine Algae Collected from Karachi-coasts of Arabian Sea
Muhammad Shaiq Ali,Muhammad Jahangir,Muhammad Saleem,Muhammad Kashif Pervez,Shaista Hameed,Viqar Uddin Ahmad 한국생약학회 2000 Natural Product Sciences Vol.6 No.2
The ethanolic extracts of marine green, brown and red algae collected from Karachi coasts of Arabian Sea afforded a new enol-derivative of N-acylsphingosine named as coelarthenol (1) from Coelarthrum muelleri, two new glucose-derivatives named: botryenal (2) and botryenol (3) from Botryocladia leptopoda, α-tocopherol quinone (4) from Codium iyengarii, β-sitosterol and hexadecanoic acid from Stokeyia indica. The known constituents (4, β-sitosterol & hexadecanoic acid) have not been reported so far from their corresponding sources and the structures were determined through spectroscopic methods, whereas, the structures of new constituents (1-3) were elucidated with the aid of selective HMBC experiments. The phytotoxicity of 4 was also monitored.