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Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2
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Do Testicular Seminoma and Nonseminoma Share the Same Etiology? Evidence from an Age-Period-Cohort Analysis of Incidence Trends in Eight European Countries
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간호업무와 법적책임
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The Characteristics of an Ultra-High Resolution Ge(Li) Spectrometer for Singles and Coincidence X-Ray and Gamma-Ray Studies
- 검색키워드
- 저자 : Vinod Mokale (검색결과 3 건)
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Vinod Mokale,Naik Jitendra,Sutar Yogesh,Khairnar Gokul 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.4
The work investigates the development andoptimization of chitosan-alginate beads containing Losartanpotassium (LP) through ionotropic/external gelationtechnique using 32 factorial design. The effect of polymerblendconcentrations i.e. chitosan and sodium alginate onthe drug encapsulation efficiency (DEE%), and cumulativedrug release after 20 h (R20h %) was optimized. The DEE%of all these beads was within the range of 67.12 ±1.97–89.81 ± 1.52 % with sustained in vitro drug releaseof 80.98–97.13 % over 20 h. The in vitro drug release fromthese beads was followed first order kinetic model. Thebeads were also characterized by FE-SEM, FTIR and XRDanalysis. The swelling of chitosan–alginate beads containingLP were influenced by the pH of the test medium. Chitosan coated alginate beads were developed as oralsustained delivery carriers for LP in order to improvepatient compliance, to reduce side effects associated with itand also to reduce the dose/dosing frequency in the managementof hypertension.
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Gokul Khairnar,Jitendra Naik,Vinod Mokale 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.6
The aim of this study was to investigate thecombined influence of 3 independent variables in thepreparation of sustained release Nateglinide (NTG)microspheres by O/W solvent emulsification method. A3-factor, 3-level Box–Behnken design was used to derivesecond order polynomial equation and construct contourplots to predict responses. The independent variablesselected were polymer concentration (A), surfactant concentration(B) and speed of the stirrer (C). Percentage drugloading (Y1) and Percentage drug release (Y2) were considereddependent variables. The prepared microsphereswere evaluated for percentage of yield, drug loading, drugrelease study in 6.8 phosphate buffer, Fourier transforminfrared (FT-IR), X-ray diffraction (XRD), scanning electronmicroscopy analysis. Contour plots were constructedto show the effects of of A, B, C on Y1 and Y2. The yieldof microspheres was found to be in the range of42.29–97.22 %. The drug loading was found to be in therange of 12.18 % (F9) to 24.55 % (F14). FT-IR analysisrevealed no drug excipient interference. The morphologyof evaluated microspheres were found to be spherical andsmooth in nature. In XRD analysis crystalline pattern ofpure NTG was changed to amorphous pattern when convertedto microspheres. Out of 17 batches, formulationbatches F1, F4, F12, F14, F17 had percentage drug loading52.75, 50.78, 43.88, 47.45, 44.78 % at 10 h respectivelywhich indicated excellent sustained drug release pattern. From this study it was concluded that NTG loaded ethylcellulose sustained release microspheres were developedusing 3-factor, 3-level Box–Behnken design.
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High performance visible light photocatalysis of electrospun PAN/ZnO hybrid nanofibers
Akshara P. Shah,Shilpa Jain,Vinod J. Mokale,Navinchandra G. Shimpi 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-
ZnO nanorods (NRs) immobilized PAN nanofibers were prepared using electrospinning technique. ZnOwere dispersed uniformly, which helps to overcome the difficult recycling of powder catalyst. The asobtainedfibers were characterized with wide-angle powder X-ray diffraction (XRD), scanning electronmicroscopy (SEM), transmission electron microscope (TEM), Fourier transform infrared spectroscopy(FTIR), UV-vis diffuse reflectance spectrophotometry (UV-vis-DRS), Thermogravimetry analysis (TGA), N2adsorption–desorption isotherms (BET), and X-ray photoelectron spectrometer (XPS). The morphologicalstudies revealed that ZnO NRs were aligned parallel to the axis offibers. PAN/ZnO hybrid NFs showsbetter regularity and uniformity in diameter (~800 nm) with large specific surface area and smaller energyband gap comparted to ZnO NRs. Under visible light irradiation, PAN/ZnO hybrid nanofibers have hadexcellent photocatalytic performances for the degradation of cationic MG dye (200 min, 99%) and anionicMO dye (280 min, 99%) respectively. Due to the electrostatic attraction between cationic dye and anionicPAN/ZnO, the degradation rate towards MG dye was higher than MO dye. Recyclability study shows thatafterfifth cycle, 93% efficiency was observed.
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