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- 저자 : Villagra, A. (검색결과 4 건)
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Vahid Jabbari,Masood Hamadanian,Sajad Karimzadeh,Dino Villagra´n 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-
C–N–S-tridoped TiO2 nanoparticles is synthesized via sol–gel method using cysteine as nonmetalssource. Moreover, to suppress recombination of photogenerated charge carriers, silver nanoclusters aredeposited over C–N–S-tridoped TiO2 via photodeposition technique and the catalyst Ag@C,N,S–TiO2 isdeveloped. The prepared catalysts are characterized by XRD, SEM-EDAX, TEM, XPS, IR, Raman, UV–visDRS, and N2 adsorption–desorption isotherms. Our findings show that Ag@C,N,S–TiO2 catalyst has anexcellent and outstanding photocatalytic performance compared to that of pure TiO2 and commercialTiO2 P25 which the reason is attributed to improved visible-light harvesting, enhanced organic pollutantadsorption and increased photo-efficiency in separation of the charge carriers.
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Sumsuzzman Dewan Md.,Khan Zeeshan Ahmad,Nila Irin Sultana,Moran Vanina Myuriel Villagra,Rajesh Madhuvilakku,Yang Won Jong,Hong Yonggeun 대한재활의학회 2024 Annals of Rehabilitation Medicine Vol.48 No.3
We conducted a systematic review and meta-analysis to examine the protective effects of botulinum toxin-A (Botox-A) on spasticity and nociceptive pain in individuals with spinal cord injuries (SCIs). PubMed, Embase, and Cochrane Library databases were searched from inception to July 2023. The primary outcome of interest was spasticity and nociceptive pain. We pooled the available data using the generic inverse variance method, and we used a fixed-effect/random-effects model. We then calculated standardized mean difference (SMD) and 95% confidence intervals (95% CIs) to estimate the effect size. A total of fourteen studies meeting the inclusion criteria comprised two randomized controlled trials, five pre-post studies, and seven case reports. Across the various study designs, the majority of trials were assessed to have fair to high quality. The meta-analysis shows that Botox-A significantly decreased spasticity (SMD, -1.73; 95% CI, -2.51 to -0.95; p<0.0001, I2=48%) and nociceptive pain (SMD, -1.79; 95% CI, -2.67 to -0.91; p<0.0001, I2=0%) in SCI patients. Furthermore, Botox-A intervention improved motor function, activities of daily living (ADL), and quality of life. Our study suggests that Botox-A may alleviate spasticity and nociceptive pain in SCI patients. Moreover, the observed improvements in motor function, ADL, and overall quality of life following Botox-A intervention underscore its pivotal role in enhancing patient outcomes.
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Kamran Kashif,Schapheer Constanza,Ali Abid,Maldonado Ana Karina,Iqbal Asim,Arif Sana,Villagra Cristian 한국곤충학회 2021 Entomological Research Vol.51 No.12
Synanthropic cockroaches are a public health concern, because they can carry pathogens and allergens. These insects inhabit urban spaces and must be constantly monitored in order to assess the pest emergence outbreaks. Here, we combined spatial population monitoring with microbiological testing to survey the main pest cockroach species found inside residences of the city of Quetta, Pakistan. We evaluated the distribution of pest cockroaches at two scales: landscape (neighborhood) and patch (inside houses). We found at least one of the following pest species in the 73.2% of the total residences surveyed (n = 112): Shelfordella lateralis 37.1%, Periplaneta americana 23%, Blatella germanica 16.7%, Blatta orientalis 13.4% and Polyphaga aegyptiaca 9.8%. At landscape scale, the most common was S. lateralis, presenting a clustered distribution in two sampled zones, also heavily urbanized. At indoor scale, S. lateralis were most frequently found in kitchens. When we studied the bacterial loads in this species, we found that S. lateralis carried several pathogenic bacteria. Susceptibility tests tested on these strains against 10 common formulations showed antibiotic resistance for some bacteria. For instance, Pasteurella spp was susceptible towards six antibiotics tested, while Helicobacter spp showed resistance against eight antibiotics tested. Our evidence suggests that S. lateralis have the potential to displace main cosmopolitan pests and, most concerning, also carry antibiotic-resistant pathogenic bacteria. Considering that this emergent Asian-native pest is now present in Europe and America, it may correspond to a relevant urban pest deserving further international public health attention.
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Sahakian, E.,Powers, J.J.,Chen, J.,Deng, S.L.,Cheng, F.,Distler, A.,Woods, D.M.,Rock-Klotz, J.,Sodre, A.L.,Youn, J.I.,Woan, K.V.,Villagra, A.,Gabrilovich, D.,Sotomayor, E.M.,Pinilla-Ibarz, J. Pergamon Press 2015 Molecular immunology Vol.63 No.2
Myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells capable of suppressing anti-tumor T cell function in the tumor microenvironment, represent an imposing obstacle in the development of cancer immunotherapeutics. Thus, identifying elements essential to the development and perpetuation of these cells will undoubtedly improve our ability to circumvent their suppressive impact. HDAC11 has emerged as a key regulator of IL-10 gene expression in myeloid cells, suggesting that this may represent an important targetable axis through which to dampen MDSC formation. Using a murine transgenic reporter model system where eGFP expression is controlled by the HDAC11 promoter (Tg-HDAC11-eGFP), we provide evidence that HDAC11 appears to function as a negative regulator of MDSC expansion/function in vivo. MDSCs isolated from EL4 tumor-bearing Tg-HDAC11-eGFP display high expression of eGFP, indicative of HDAC11 transcriptional activation at steady state. In striking contrast, immature myeloid cells in tumor-bearing mice display a diminished eGFP expression, implying that the transition of IMC to MDSC's require a decrease in the expression of HDAC11, where we postulate that it acts as a gate-keeper of myeloid differentiation. Indeed, tumor-bearing HDAC11-knockout mice (HDAC11-KO) demonstrate a more suppressive MDSC population as compared to wild-type (WT) tumor-bearing control. Notably, the HDAC11-KO tumor-bearing mice exhibit enhanced tumor growth kinetics when compare to the WT control mice. Thus, through a better understanding of this previously unknown role of HDAC11 in MDSC expansion and function, rational development of targeted epigenetic modifiers may allow us to thwart a powerful barrier to efficacious immunotherapies.
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