Ni-Co/Fe₃O₄ flower-like nanocomposite for the highly sensitive and selective enzyme free glucose sensor applications

Vennila, P.,Yoo, Dong Jin,Kim, Ae Rhan,kumar, G. Gnana Elsevier 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.703 No.-

<P><B>Abstract</B></P> <P>The electrochemically active non-enzymatic glucose sensor probes on the basis of nickel-cobalt (Ni-Co)/iron oxide (Fe<SUB>3</SUB>O<SUB>4</SUB>) nanocomposite was developed by using a simple chemical phase technique. The morphological characterizations revealed that Ni-Co and its composite with Fe<SUB>3</SUB>O<SUB>4</SUB> exhibited the flower-like morphology with the strongly interlaced nanosheets. The electrocatalytic performances of as-prepared nanostructures toward glucose oxidation were investigated by using cyclic voltammetry and amperometric techniques. Ni-Co/Fe<SUB>3</SUB>O<SUB>4</SUB> nanocomposite exhibited a fast response toward non-enzymatic glucose detection and the obtained amperometric signals are linearly proportional to the glucose concentration ranging from 1 μM to 11 mM, showing a low detection limit of 0.19 μM and a high sensitivity of 2171 μA/mM.cm<SUP>2</SUP>. The as-fabricated sensor demonstrated the real time applications in human serum samples with the appreciable recovery and also exhibited the excellent performances in terms of selectivity, reliability, good accuracy and reproducibility, which geared up the potential exploration of as-prepared catalysts in highly sensitive and selective enzyme free glucose sensor applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> One pot synthesis of 3D flower like Ni-Co/Fe<SUB>3</SUB>O<SUB>4</SUB> nanocomposite is developed. </LI> <LI> Formation and growth mechanism of 3D flower like structure is elucidated. </LI> <LI> Ni-Co/Fe<SUB>3</SUB>O<SUB>4</SUB> exhibited high sensitivity and lower detection limit toward glucose. </LI> <LI> Glucose electrooxidation mechanism at Ni-Co/Fe<SUB>3</SUB>O<SUB>4</SUB> is schemated. </LI> <LI> The analytical reliability of fabricated sensor is evaluated in real samples. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Efficacy of Sesamol on Plasma and Tissue Lipids in Isoproterenol- Induced Cardiotoxicity in Wistar Rats

Lakshmanan Vennila,Kodukkur Viswanathan Pugalendi 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8

Myocardial infarction is the leading cause of death all over the world. Sesamol is a potent phenolic antioxidant contained only in processed sesame oil and possesses potent chemopreventive, antimutagenic, antihepatotoxic and antioxidation properties. This study was undertaken to investigate the effect of sesamol on plasma and tissue lipid profiles in isoproterenol (ISO) -induced rats. Myocardial infarction was induced in adult male albino rats of the Wistar strain, weighing 180-200 g, by administration of isoproterenol (85 mg/kg of body weight), subcutaneously for 2 consecutive days. Sesamol dissolved in saline (0.9% NaCl) was administered intraperitoneally once in a day in the morning for 7 days. Increased levels of total cholesterol,phospholipids, triglycerides and free fatty acids in the plasma and the decreased levels of phospholipids in tissues were observed in ISO-induced rats. Very low density lipoprotein cholesterol (VLDL-C) and low density lipoprotein cholesterol (LDL-C) increased while high density lipoprotein cholesterol (HDL-C) decreased in the plasma of ISO-induced rats. Administration of sesamol (50, 100 and 200 mg/kg of body weight) improved the above changes and brought towards normal level. The protective role of sesamol against isoproterenol-induced myocardial infarction was further confirmed by histopathological examination. These results suggest that sesamol has antihyperlipidaemic effect against cardiotoxicity.

An Energy Efficient Clustering Algorithm in Mobile Adhoc Network Using Ticket Id Based Clustering Manager

Venkatasubramanian, S.,Suhasini, A.,Vennila, C. International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.7

Many emerging mobile ad-hoc network application communications are group-oriented. Multicast supports group-oriented applications efficiently, particularly in a mobile environment that has a limited bandwidth and limited power. Energy effectiveness along with safety are 2 key problem in MANET design. Within this paper, MANET is presented with a stable, energy-efficient clustering technique. In this proposed work advanced clustering in the networks with ticket ID cluster manager (TID-CMGR) has formed in MANET. The proposed routing scheme makes secure networking the shortest route possible. In this article, we propose a Cluster manager approach based on TICKET-ID to address energy consumption issues and reduce CH workload. TID-CMGR includes two mechanism including ticket ID controller, ticketing pool, route planning and other components. The CA (cluster agent) shall control and supervise the functions of nodes and inform to TID-CMGR. The CH conducts and transfers packets to the network nodes. As the CH energy level is depleted, CA elects the corresponding node with elevated energy values, and all new and old operations are simultaneously stored by CA at this time. A simulation trial for 20 to 100 nodes was performed to show the proposed scheme performance. The suggested approach is used to do experimental work using the NS- simulator. TIDCMGR is compared with TID BRM and PSO to calculate the utility of the work proposed. The assessment shows that the proposed TICKET-ID scheme achieves 90 percent more than other current systems.

Real-time biofeedback device for gait rehabilitation of post-stroke patients

I-Hung Khoo,Panadda Marayong,Vennila Krishnan,Michael Balagtas,Omar Rojas,Katherine Leyba 대한의용생체공학회 2017 Biomedical Engineering Letters (BMEL) Vol.7 No.4

In this work, we develop a device, called ‘Walk-Even’, that can provide real-time feedback to correct gaitasymmetry commonly exhibited in post-stroke survivorsand persons with certain neurological disorders. The devicecomputes gait parameters, including gait time, swing time,and stance time of each leg, to detect gait asymmetry andprovide corresponding real-time biofeedback by means ofauditory and electrotactile stimulation to actively correctthe user’s gait. The system consists of customized forcesensor-embedded insoles adjustable to fit any shoe size,electrotactile and auditory feedback circuits, microcontroller,and wireless XBee transceivers. The device alsooffers data saving capability. To validate its accuracy andreliability, we compared the gait measurements from ourdevice with a commercial gait and balance assessmentdevice, Zeno Walkway. The results show good correlationand agreement in a validity study with six healthy subjectsand reliability study with seventeen healthy subjects. Inaddition, preliminary testing on six post-stroke patientsafter an 8-week training shows that the Walk-Even devicehelps to improve gait symmetry, foot pressure and forefootloading of the affected side. Thus, initial testing indicatesthat the device is accurate in measuring the gait parametersand effective in improving gait symmetry using real-timefeedback. The device is portable and low cost and has thepotential for use in a non-clinical setting for patients thatcan walk independently without assistance. A moreextensive testing with stroke patients is still ongoing.

Tritrophic Interactions of Cowpea [Vigna unguiculata subsp unguiculata(L.)], Aphids [Aphis craccivora (Koch)] and Coccinellids [Menochilus sexmaculatus (Fab.)] under eCO2 and eTemp

M. Srinivasa Rao,O. Shaila,P. Sreelakshmi,S. Vennila,M. Vanaja,A.V.M. Subba Rao,M. Maheswari,K. Sammi Reddy 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.2

Experiments were conducted to understand the direct and indirect effects of temperature and elevated CO2 (eCO2), on tritrophic interactions of cowpea (Vigna unguiculata subsp. unguiculata L.), legume aphid Aphis craccivora Koch and coccinellid predator Menochilus sexmaculatus Fab. Reduction of the leaf nitrogen (6%), amino acid (6%) and protein (7%) of cowpea foliage with increased carbon (13%) and C:N ratio (21%) at eCO2 over aCO2 indicated the dilution of biochemical constituents at first trophic level. Shortened development time, DT and increment of reproductive rate, RR at eCO2 over ambient CO2(aCO2)was significant with increase in temperature from 20 to 35 °C. Reduction of the mean degree day, DD requirement of both nymphal (75.79 ± 15.163) and adult stages (157.15 ± 67.04) at eCO2 over aCO2 and same was reflected in the summation DD for both the stages at eCO2 (232.96 ± 80.32)and aCO2 (247.07 ± 64.77) across six temperatures. The ‘rm’ and ‘Ro’ increased gradually with increase in temperature followed the non-linear trend and reached maximum values at 27 °C with shortened ‘T’ across 20 to 35 °C temperatures at eCO2 indicating the significant variation of growth and development at the second trophic level. Decreased grub duration (23%) with increased predation capacity (19%) of M. sexmaculatus on A. craccivora at eCO2 over ambient was noted, indicating the incidence of A. craccivora is likely to be higher with increased predation in the future climate change scenario.