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RISS 인기검색어
- 검색키워드
- 저자 : Velazquez-Armenta, E. Yadira (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Kwak, Ho-Seok,Han, Jung-Yeol,Choi, June-Seek,Ahn, Hyun-Kyong,Ryu, Hyun-Mee,Chung, Hee-Jung,Cho, Dong-Hee,Shin, Chan-Young,Velazquez-Armenta, E. Yadira,Nava-Ocampo, Alejandro A. Informa Healthcare 2014 Clinical toxicology Vol.52 No.1
<P><I>Objective.</I> Phosphatidylethanol (PEth) is formed endogenously by the direct action of ethanol, and has a half-life long enough to make it a reliable biomarker of alcohol exposure in early pregnancy. In this study, we aimed to characterize PEth blood concentrations to differentiate different levels of alcohol exposure in pregnant women. <I>Methods.</I> The study consisted of 305 consecutive pregnant women who had been referred to our hospital for antenatal care. Of them, 117 self-reported alcohol ingestion in the first trimester of pregnancy and 188 were abstainers. Total PEth concentration in whole blood was quantified by liquid chromatography-mass spectrometry (LC-MS/MS). Alcohol ingestion was classified according to the United States National Institute on Alcohol Abuse and Alcoholism into light drinkers: ≤ 3 drinks/week, moderate drinkers: 3-7 drinks/week, and heavier drinkers: > 7 drinks/week (a standard drink = 14 g of ethanol). <I>Results.</I> Participants had quantifiable PEth blood levels 3-4 weeks after the last drink. There were 4.8% abstainers who had positive PEth concentrations; all of them reported a positive history of alcohol consumption before conception. PEth blood concentrations were significantly correlated to drinks per occasion (<I>r</I> = 0.44; <I>P</I> < 0.001) and days drinking per week (<I>r</I> = 0.34; <I>P</I> < 0.001). However, almost 74% of participants with ≤ 3 drinks/week of alcohol, and 46% with 3-7 drinks/week, had PEth blood concentrations below the lower limit of quantification (LLOQ). The area under the curve (AUC) generated by a receiver operation characteristic curve (ROC) analysis increased as the cutoff value of PEth blood concentration increased. However, the cutoff values were below or close to the LLOQ. <I>Conclusions:</I> Our study presents a formal characterization of PEth blood concentrations for screening alcohol ingestion in first-trimester pregnant women. However, caution is recommended for overrepresenting either negative or positive results.</P>
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Kwak, Ho Seok,Han, Jung-Yeol,Ahn, Hyun-Kyong,Kim, Min-Hyoung,Ryu, Hyun-Mee,Kim, Moon-Young,Chung, Hee-Jung,Cho, Dong-Hee,Shin, Chan-Young,Velazquez-Armenta, Elvia Y.,Nava-Ocampo, Alejandro A. Informa Healthcare 2012 Clinical toxicology Vol.50 No.10
<P><I>Objective.</I> A reliable biomarker of low alcohol exposure during pregnancy is needed to clarify the controversy on the teratogenicity of low-to-moderate alcohol levels. <I>Methods.</I> Blood samples were obtained from 13 pregnant women who self-reported alcohol ingestion between 2.5 and 20 drinks/week, and from 26 controls. Total lipids were extracted, and phosphatidylethanol (PEth) species 16:0/16:0, 16:0/18:1, and 16:0/18:1 were separated by high-performance liquid chromatography (HPLC) on a reverse-phase phenyl column. These PEth species were quantified by MS/MS using phosphatidylpropanol as internal standard, with electrospray ionization and MRM. <I>Results.</I> PEth species were not detected in women who abstained from alcohol ingestion during pregnancy, whereas PEth-16:0/18:1 was > 5 nmol/L in those with positive alcohol ingestion. PEth species were detected for up to 4 weeks after cessation of exposure. <I>Conclusions.</I> PEth-16:0/18:1 was detected in pregnant women at 4-6 weeks after their last low-to-moderate alcohol ingestion, and therefore appears to be a reliable biomarker of prenatal alcohol exposure to study the teratogenicity of alcohol at these exposure levels.</P>
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