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Sequence Variation in SlMYB12 is Associated with Fruit Peel Color in Pink Tomato Cultivars
Karpagam Veerappan,정희정,황인덕,고강희,정미영,노일섭 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.3
The peel of pink-colored tomato is transparent due to the lack of accumulation of the flavonoid naringenin chalcone during ripening. A strong correlation was found between flavonoid expression and the function of SlMYB12, which is a transcriptional regulator of flavonoid biosynthesis. Thus, SlMYB12 is a strong candidate gene underlying the pink phenotype. Three allelic variants, a 603 bp deletion, a nucleotide substitution (C > T), and a 1 bp insertion (TG > TAG) in the SlMYB12 gene have been previously reported. We performed PCR genotyping based on these three allelic variations in 47 tomato cultivars displaying either a pink or red phenotype. However, the genotype did not match with the expected phenotype in one pink cultivar “Prime Alexander”. This cultivar was therefore self-pollinated to produce 20 progeny plants. To identify new mutations in SlMYB12, the sequence of genomic DNA and CDS were compared between the progeny 17 and the reference line, Heinz 1706. A novel G > T nucleotide substitution was found in the 2nd intron. This SNP leads to a deletion of 7 bp (GTAACAG) from the end of the 2nd exon, resulting in a premature stop codon. The presence of this SNP associates the pink phenotype with the genotype. This novel SNP will be useful as a genetic marker for marker-assisted breeding of pink tomato.
Kim Kwangmin,Veerappan Karpagam,Woo Nahyun,Park Bohyeon,Natarajan Sathishkumar,Chung Hoyong,김철민,Park Junhyung 한국미생물학회 2021 The journal of microbiology Vol.59 No.12
The stem and root bark of Ulmus macrocarpa Hance has been used as traditional pharmacological agent against inflammation related disorders. The objective of this study was to explore the impact of Ulmus macrocarpa Hance extract (UME) on human gut microbiota. A randomized placebo-controlled clinical study was conducted in healthy adults. The study subjects were given 500 mg/day of UME or placebo orally for 4 weeks. Eighty fecal samples were collected at baseline and 4 weeks of UME or placebo intervention. The gut microbiota variation was evaluated by 16S rRNA profiling. The microbial response was highly personalized, and no statistically significant differences was observed in both species richness and abundance. The number of bacterial species identified in study subjects ranged from 86 to 182 species. The analysis for taxonomical changes revealed an increase in Eubacterium ventriosum, Blautia faecis, Ruminococcus gnavus in the UME group. Functional enrichment of bacterial genes showed an increase in primary and secondary bile acid biosynthesis in UME group. Having known from previous studies Eubacterium regulated bile acid homeostasis in protecting gut microbial architecture and immunity, we suggest that UME supplementation might enhance host immunity by modulating gut microbiota. This is the first stage study and forthcoming clinical studies with larger participants are needed to confirm these findings.
Perumalsamy, Haribalan,Sankarapandian, Karuppasamy,Veerappan, Karpagam,Natarajan, Sathishkumar,Kandaswamy, Narendran,Thangavelu, Lakshmi,Balusamy, Sri Renukadevi Elsevier 2018 Phytomedicine Vol.46 No.-
<P>Conclusion: Our study denotes that SSBC could be very effective against AGS by inducing apoptosis through intrinsic pathway and recommended for in vivo and human trials.</P>
Lee Joon Ha,Chung Hoyong,Shin Yong Pyo,Kim In-Woo,Natarajan Sathishkumar,Veerappan Karpagam,Seo Minchul,Park Junhyung,Hwang Jae Sam 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.2
Evolutionary immune system upgradation is done by all living organism to survive from the invading pathogens. Insects has a strong defense system comprising of anatomical barrier, humoral antimicrobial peptide (AMP) production and cellular immune components. Locusta migratoria (L. migratoria) is an agricultural pest insect migrating long distance might encounter distinct pathogens. Owing to this, we aimed in identifying AMPs present in the L. migratoria and elucidate the antimicrobial activity. The migratory locust was immunized with Escherichia coli, Staphylococcus aureus, Candida albicans mixture, then RNA was isolated and sequenced. The L. migratoria transcriptome was de novo assembled using trinity and screened for AMPs propensity specifically molecular and aggregation properties. The novelty is tested by blasting in known AMP databases. Finally, ob tained novel putative AMPs were then tested for antimicrobial and hemolytic activity. The prediction resulted in 3,524 putative AMPs which was further screened down to ten AMPs for final testing. Two peptides showing promising antimicrobial effects were obtained. All the analyzed peptides showed no hemolysis confirms its nontoxicity. Thus, our peptides could be promising drug candidate and can be used as an alternative to antibacterial or antifungal therapy with further validations.