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      • The potential role of secondary metabolites in modulating the flavor and taste of the meat

        Ramalingam, Vaikundamoorthy,Song, Zhen,Hwang, Inho Elsevier Science B.V., Amsterdam. 2019 Vol. No.

        <P><B>Abstract</B></P> <P>Flavor is one of the most significant characteristics of beef palatability and it can eventually affect the consumer's acceptance of a beef product and purchasing habits. Variation in beef quality is large and is due to many factors, such as differences in genetic background, sex, age, management and nutrition. The consumer's decision to purchase beef is guided by the perception of healthiness and a variety of sensory traits including color, tenderness, juiciness, and aroma or flavor. Apart from this, there are several factors including peptides, fatty acids, amino acids, vitamins, fat contents are also play a vital role in determining the taste and flavor of the meat. In this review, we try to explore and explain the potential role of these factors in modulating the flavor and taste of the meat in detail.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The novelty and significance of the work are as follows: </LI> <LI> Sensory properties of the meat. </LI> <LI> Effect of Maillard reaction in modulating the quality of the meat. </LI> <LI> Role of secondary metabolites in taste and flavor of the meat. </LI> <LI> Perception of the flavor in the meat quality. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • KCI등재

        Zinc oxide nanoparticles promoting the formation of myogenic differentiation into myotubes in mouse myoblast C2C12 cells

        Vaikundamoorthy Ramalingam,Inho Hwang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.83 No.-

        In the present study, we investigated the effect of monodispersed zinc oxide (ZnO) nanoparticles on theproliferation, myogenic differentiation and regulation of associated myogenic marker genes. The aspreparedZnO nanoparticles had the hexagonal wurtzite structure with maximum absorption at 355 nmand the band gap energy was found to be 3.21 eV. The electron microscopy analysis showed that the ZnOnanoparticles are spherical in shape with an average size range between 10 to 15 nm. The XRD analysisconfirmed the hexagonal structure of ZnO nanoparticles and the Raman spectroscopic analysis showedthe vibrations of the zinc lattice and oxygen vibration of ZnO nanoparticles. The effect of ZnOnanoparticles on myogenic differentiation was analyzed using C2C12 cells and the results showed thenanoparticles supported the proliferation with negotiable cytotoxic activity. Moreover, the ZnOnanoparticles were significantly enhanced the myoblasts into myotube formation through upregulatingthe myogenic markers such as myosin heavy chain, MyoD, MyoG genes. The further analysisdemonstrated that the ZnO nanoparticles regulates the non-apoptotic effect of caspases and calpainfamily proteins in respond to the enhancement of myogenic differentiation. Together, the ZnOnanoparticles provide an additional evidence for the role of nanomaterials in skeletal muscle repair andtissue regeneration engineering.

      • KCI등재

        (Zn, Ni)-ferrite nanoparticles for promoted osteogenic differentiation of MC3T3-E1 cells

        Harshavardhan Mohan,Natesan Karthi,Pavithra Muthukumar Sathya,Vaikundamoorthy Ramalingam,Srivalli Thimmarayan,호싸인암자드,Adithan Aravinthan,신태호 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-

        The structural composition and functionality of bone tissues has been significantly impacted due to progressiveageing, thereby necessitating effective strategies that are not just about temporary cure butabout permanent regeneration of tissues, one such being regenerative medicine. Of the several noveltiesin the field, the provocation of osteogenesis involving nanoparticles has gained significant attention fortheir heightened efficiency and cost effectiveness. Magnetic materials in particular have been increasinglypaid attention to owing to their edge over stability, non-toxicity and feasibility to spatially trackusing MRI. The present study involves the synthesis of Zn and Ni doped ferrite ((Zn, Ni)-ferrite) nanoparticlesinvolving chemical co-precipitation method. The materials were evaluated against MC3T3 cellstowards ROS induced osteogenic differentiation properties, and the results implied very less toxicity evenat concentration surpassing 50 lg/ml in addition to the void of necrosis after treatment with 2.5 and5 lg/ml of (Zn, Ni)-ferrite. FACS results implied 1% cell staining with propidium iodide after 24 h exposureat 2.5 lg/ml concentrations of (Zn, Ni)-ferrite, thereby substantiating (Zn, Ni)-ferrite as a potentialbiomaterial in favor of regenerative medicine.

      • 한우 우둔살의 질김도와 섬유아세포 내 칼페인 단백질의 발현

        서승준 ( Seung-joon Seo ),김건우 ( Gun-woo Kim ),전희찬 ( Hee-chan Jeon ),이준호 ( Jun-ho Lee ),박경민 ( Kyung-min Park ),박희태 ( Hee-tea Park ),라마린감 ( Ramalingam Vaikundamoorthy ) 전북대학교 농업과학기술연구소 2019 농업생명과학연구 Vol.50 No.2

        The present study was designed to identify the role of collagen and its associated genes in the differential toughness of the bovine muscle. The fibroblasts were isolated from m. semimembranosus (SM) Hanwoo steer quality grade 1 which has high toughness in nature. Initially, the growth curve analysis showed the different proliferation rate in SM fibroblasts over the period time was measured using CCK8 assay. Further, the genes responsible for collagen synthesis were highly expressed in SM fibroblasts and also the collagen degrading genes are decreased in expression in fibroblast derived from SM. Together, the fibroblasts derived from SM muscles have a high toughness was confirmed by collagen content and expression analysis of associated genes.

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