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Annie Abraham,P.G. Biju,V. Gayathri Devi,Y. Lija 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
Dregea volubilisis a woody climbing plant commonly found in the hotter parts of India. The leaves are edi-ble and used as a green vegetable, while the plant extract has been used traditionally to treat several diseases including eyeailments. Drevogenin D is a triterpenoid aglycone that has been isolated, purified, and characterized as an active componentfrom the leaves of D. volubilis. In this study, drevogenin D was evaluated for antioxidant and potential anticataractogenic ac-tivity in an in vitromodel. 1,1-Diphenyl-2-picrylhydrazyl radical and superoxide radical scavenging activities of drevogeninD were studied and found to exhibit a 50% inhibitory concentration of 43 .g/mL and 200.6 .g/mL, respectively. Normal ratlenses cultured in 0.1 mM sodium selenite-supplemented medium were used as the experimental model for this study. Selen-ite-induced models are excellent mimics of oxidative stress induced cataract. Treatment with drevogenin D at a concentrationof 50 .g/mL medium was found to reverse the level of activity of superoxide dismutase, catalase, glutathione peroxidase, andglutathione reductase, elevate the level of reduced glutathione and protein sulfhydryl, and lower the level of lipid peroxida-tion as indicated by the concentration of thiobarbituric acid-reacting substances. These results indicate good antioxidant ac-tivity and potential anticataractogenic activity for drevogenin D against selenite-induced cataractous changes, which have beenreported for the first time.