ẢNH HƯỞNG CỦA VĂN HOÁ TRONG VIỆC TIẾP NHẬN PHIM TRUYỀN HÌNH NƯỚC NGOÀI CỦA KHÁN GIẢ VIỆT NAM

ThS. Quách Thuyên Nhã Uyên 한국베트남학회 2022 한국베트남학회 학술대회 Vol.2022 No.06

Acetylcholine에 의한 적출 십이지장 평활근 수축에 미치는 Calcium 길항제의 영향

손의동,이만기,박창호,김인겸,김중영 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.2

To compare antagonistic action of caloium antagonists on intestinal smooth muscle contraction, acetylcholine-induced phasic contraction (PC) and tonic contraction (TC) initiated by different calcium utilization were observed in the presence of various calcium antagonists by the use of isolated mouse duodenum suspended in Tyrode's solution. By verapamil at 2.2×10 exp(-6), 2.2×10 exp(-5) and 2.2×10 exp(-4) mM, PC was more decreased dose-dependently than TC. By nifedipine at 7.9×10 exp(-5) mM, PC was more decreased than TC, but at 7.9×10 exp(-6) mM it did not affect PC and TC. By diltiazem at 6.1×10 exp(-4) mM, PC was more decreased than TC, but at 2.4×10 exp(-4) and 2.4×10 exp(-5) mM it did not affect both of the contractions. By cobalt chloride at 0.3, 1.3, and 2.6 mM, TC was significantly decreased without affecting PC, but PC markedly decreased at 5.2 mM. These results reconfirmed the fact that cobalt ion-induced calcium antagonism is more related to calcium influx process than calcium release process in contrast with the actions of verapamil, diltiazem, and nifedipine in duodenal smooth muscle.

소아과 환자의 처방분석 및 검토

이종미,손의동 중앙대학교 약학연구소 2002 약학 논총 Vol.16 No.-

It is known that drug therapy of children is different from that of adults and the prescription is needed to the cautious, because drug's safety and dosage are not established. When the capsule is changed to powder form in pediatric patients, the effect and safety of treatment maybe lost. So I investigated the drug interactions and the alternation of dosage forms in dispensing of oral drug products for pediatric patients based on the prescriptions of Hospital A. One prescription is composed of 5.3 drugs, is prescribed an average 4.9 days and the pediatrics in hospital A used kinds of 145 drugs during January, 2002. Mucolytics are most common in prescriptions(49.6%), digestives, antibiotics, antihistamines and antipyreptics in senior. The most common disease is asthma in pediatric patients, sinusitis, rhinitis, bronchitis and pharyngitis in order. Among 11,534 prescriptions for 2,163 patients' drug interaction were found 133 cases, and most drugs belong to macrolides and asthma related drugs but not seriously. Among 21,678 prescriptions, the cases of alternation of dosage forms (tablets and capsules intended for constitution as powders) were 17,950 (83%), this result is showed that adult typed drugs are popular in pediatric department. The most common changing drug is fenoterol and the other drugs are theophylline, bromhexine, ketotifen fumarate, in order. Number of powder formed drug with decreased effectivenes, unplesant swelling and bitter tastes when powder formed are 726 cases. On the basis of the results of this study, several problems caused by the alternation were discussed, such as changes in bioavailability loss in dose, stability and the problem of feeding. It was suggested that the information in alternation must be given by the pharmaceutical manufacturer and the hospital pharmacists must consider these problems in pediatric dispensing. Above all, it was desirable to develop pediatric dosage forms by the pharmaceutical manufacturer.

소아과의원의 감기환자 처방 분석

한인희,손의동 중앙대학교 약학연구소 2002 약학 논총 Vol.16 No.-

It has been shown that the common cold is the most prevalent disease in humans generally caused by rhinovirus etc. It may be interesting if we compare pediatric's prescriptions drugs in local clinic, and find some differences to them. This research shows that antibiotic or/and antiviral drug use(s) between two pediatric's prescriptions are quite different. There are no licensed effective antiviral drugs for the common cold. Although bacterial involvement was rare and an uncomplicated common cold did not require combination treatment with antibiotics, antiviral and antibiotic therapy prescriptions increase insurance drug prices 2.59 times. When prescribed over 2 items in same efficacy drug group to patients, it will be one of the most reason of insurance fee increment. The therapeutic periods of them was not different when we compared to symptomatic and antibiotic therapy. This analysis to the pediatric's prescriptions drugs in local clinic provide the reference data for the basic guideline of standard prescriptions. Aspirin prescriptions as antipyretics-analgesics should be reinvestigated.

천마의 항 불안 효과

김여환,최형철,손의동,이광윤,김원준,박형배,하정희 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

천마(Gastrodia elata Blume)의 근경을 말린 것은 한방에서 오래전부터 여러 형태의 간질발작 치료 목적으로 이용되어지고 있었으나 어떤 활성물질에 의해 또 어떤 작용 기전을 통해 약리작용을 나타내는지를 충분하게 설명하지 못하고 있다. 최근 항경련 작용기전 연구 결과 천마추출물의 GABA성 신경전달계에 대한 조절작용과 관련이 있을 것이라는 연구 결과가 보고되었으며, 소량으로도 뇌억제 및 진정작용이 있다는 문헌을 참고하여 볼 때 천마의 항불안 작용 가능성이 시사되었다. 이에 본 연구를 통하여 천마를 사용하여 실험동물에서 항불안 작용을 검색하고 그 작용기전의 일부를 밝히고자 항불안작용 기전에 중요한 benzodiazepine 수용체와의 상호작용을 관찰하였다. 실험 결과, 천마 추출물의 경구 장기투여는 생쥐의 elevated plus maze 검사에서 개방 통로에로의 진입 및 개방통로에서의 체류시간을 증가시킴으로써 항불안 효과를 나타내었다. 천마의 에탄올 추출물은 benzodiazepine수용체 길항제인 [³H] Ro15-1788결합을 억제하였으며, 천마 추출물은 [³H] Ro15-1788의 수용체 결합에 대한 최대 결합력(Bmax)은 변화시키지 않고, 친화력(affinity)을 감소시킴으로써 상경적인 결합 양상을 나타내었다. 또 천마의 에탄올 추출물은 benzodiazepine 수용체의 효현제인 flunitrazepam의 수용체 결합반응을 억제시켰는데, 이러한 억제는 GABA 존재하에서 항진되는 것을 관찰하였다. 이상의 결과로 미루어보아 천마의 에탄올추출물 내에는 항불안작용을 나타내는 성분이 함유되어 있을 가능성을 예상케한다. Gastrodia elata Blume is a medicinal plant which has been used as anticonvulsant in oriental medicine, and has been used as sedatives. A survey of the relevant literature has indicated that the putative anxiolytic activity of G.elata Bl. has not been scientifically investigated. Therefore, the present study was designed to assess anxiolytic property and interaction with benzodiazepine receptor of G. elata BI. The putative anxiolytic activity of ethanol extract of G. elata BI. was performed in mice using an elevated plus maze paradigm. Chronic oral administration of G. elata BI. showed anxiolytic action in mice. It was suggested that regulation of GABAergic neurotarnsmission may be important in the action of G. elata BI. The interaction of G. elata BI. with benzodiazepine receptor was investigated using rat cortices. Ethanol extract of G. elata inhibited the binding of [³H] Ro15-1788, a selective benzodiazepine receptor antagonist to benzodiazepine receptor. The inhibition of [³H] Ro15-1788 binding by G. elata BI. appeared to be competitive. Further, GABA significantly enhanced the potency of this extract in inhibiting [³H] flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. From these findings, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may contribute to the anxiolytic property of G. elata BI.

Streptozotocin으로 유발된 당뇨병쥐의 신경전도속도에 대한 Evening primrose oil (EPO), Vit.C, Vit.E의 약물효과

신창열,류정수,김학림,강봉수,손의동,허인회 중앙대학교 약학연구소 1997 약학 논총 Vol.11 No.-

The effects of evening primrose oil (EPO). Vit.C and Vit.E on nerve conduction velocity (NCV) in streptozotocin -induced diabetic rats were investigated. 5 weeks- diabetes caused 27±0.5 % reduction in sciatic motor conduction velocity as compared with normal control. Dietary supplement of 5% EPO. 125mg/kg Vit.C. and lg/kg Vit.E prevented significantly the development of the motor nerve conduction velocity deficit about 21±0.5, 21±0.5, 26±0.5% respectively. The total serum cholesterol and triglyceride were decreased by administration 5% EPO. Vit.C, and Vit.E as compared with diabetic control. However, the serum glucose was not decreased by administration 5% EPO. 125mg/kg Vit.C but the serum glucose was decreased by administration lg/kg Vit.E as compared with diabetic control.

Design Comparison by Node Width Variation of Strut-Tie-Model

Uy Lymei(오이 리마이),Byung-Jik Son(손병직) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.10

스트럿-타이 모델에서 절점 폭은 해석과 설계에서 중요하다. 그것은 트러스 유사 시스템에서 힘의 분포에 영향을 준다. 또한, 설계 코드를 만족시키기 위한 모든 스트럿 및 절점의 검증에도 영향을 미친다. 여기서 코드는 ACI-318 코드를 의미한다. 절점 폭을 결정하는 4가지 방법이 있다. 즉 1)유효 깊이를 보 높이의 0.9배로 가정하는 방법 2)모멘트 평형을 이용 하는 방법 3)절점 폭을 380mm로 가정하는 방법 그리고 4)본 연구에서 제안된 방법이다. 106개의 파라미터 연구를 분석하였 다. 그 결과 필요로 하는 총 강재량이 4가지 방법 모두 크게 차이가 나지 않기 때문에 가장 쉬운 방법으로 선택하는 것이 시간 절약 측면에서 좋을 것으로 판단된다. In the Strut-Tie-Model(STM), the width of a node is important in both analysis and design. Its effects on the force distribution at truss analogy system. In addition, it effects the verification of all struts and nodes, which need to be checked to satisfy the code of design. Code here refers to the ACI-318 code. Four methods were used to define the width of node: 1) effective depth is assumed to equal to 0.9 of the overall depth of beam, 2) moment equilibrium 3) assumption of the width of node at the bottom equal to 380mm, and 4) the new proposed method by this study. 106 selected samples of a parametric study obtained from the four methods were analyzed. Because total steel requirement from these four methods are similar, the easiest would be a good choice for a time saving calculation.

Comparison of Deep Beam by ACI Traditional and STM

( Uy Lymei ),( Byung‐jik Son ) 한국구조물진단유지관리공학회 2013 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.17 No.1

Time dependent service load behaviour of prestressed composite tee beams

Uy, Brian Techno-Press 1997 Structural Engineering and Mechanics, An Int'l Jou Vol.5 No.3

This paper is concerned with the time dependent service load behaviour of prestressed composite tee beams. The effects of creep and shrinkage of the concrete slab are modelled using the age adjusted effective modulus method and a relaxation approach. The tendon strain is determined considering compatibility of deformations and equilibrium of forces between the tendon and the composite tee beam. A parametric study is undertaken to study the influence of various aspects on the stress, strain and deformations of the concrete slab, steel beam and prestressing tendon. The effect of loading type and tendon relaxation has also been considered for various types of prestressing tendon materials. Recommendations are then made in relation to adequate span to depth ratios for varying levels of prestressing force.

EXPERIMENTAL ESOPHAGITIS AND SIGNAL TRANSDUCTION TO SMOOTH MUSCLE MOTILITY

(Uy Dong Sohn) 한국응용약물학회 1997 학술대회 Vol.1997 No.2