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The Wind of Change in Psychiatric Publications
Peter Tyrer 대한신경정신의학회 2008 PSYCHIATRY INVESTIGATION Vol.5 No.2
It is getting more difficult to get papers published that it used to be, even though many more journals are available. This article is written mainly for young researchers who are ambitious to get their research published in the best possible journals. A systematic strategic policy is suggested that does not necessarily contradict the aims of achieving the best possible science.
Controversies Surrounding Classification of Personality Disorder
김율리,Peter Tyrer 대한신경정신의학회 2010 PSYCHIATRY INVESTIGATION Vol.7 No.1
Nowadays, it is apparent that personality disorder is a common condition. Some of the concepts of personality disorder that are currently in use are flawed and need to be revised. The aim of this article is to discuss the controversy created by the uncertainties in the current classification system and to suggest ways forward. In particular, the clinician needs to be aware of the importance of assessing personality abnormality in terms of a severity dimension, and of the ways in which such an abnormality can impact on treatments for other conditions. These changes in the notion of personality disorder are needed as, for the first time, a good evidence base is being established for potential treatments and these will be maximized if we have a classification fit for therapeutic purpose.
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Phelan, Catherine M,Kuchenbaecker, Karoline B,Tyrer, Jonathan P,Kar, Siddhartha P,Lawrenson, Kate,Winham, Stacey J,Dennis, Joe,Pirie, Ailith,Riggan, Marjorie J,Chornokur, Ganna,Earp, Madalene A,Lyra J Nature Pub. Co 2017 Nature genetics Vol.49 No.5
<P>To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.</P>
Udler, Miriam S,Meyer, Kerstin B,Pooley, Karen A,Karlins, Eric,Struewing, Jeffery P,Zhang, Jinghui,Doody, David R,MacArthur, Stewart,Tyrer, Jonathan,Pharoah, Paul D,Luben, Robert,Bernstein, Leslie,Kol IRL Press ; Oxford University Press 2009 Human Molecular Genetics Vol.18 No.9
<P>Genome-wide association studies have identified FGFR2 as a breast cancer (BC) susceptibility gene in populations of European and Asian descent, but a causative variant has not yet been conclusively identified. We hypothesized that the weaker linkage disequilibrium across this associated region in populations of African ancestry might help refine the set of candidate-causal single nucleotide polymorphisms (SNPs) previously identified by our group. Eight candidate-causal SNPs were evaluated in 1253 African American invasive BC cases and 1245 controls. A significant association with BC risk was found with SNP rs2981578 (unadjusted per-allele odds ratio = 1.20, 95% confidence interval 1.03-1.41, P(trend) = 0.02), with the odds ratio estimate similar to that reported in European and Asian subjects. To extend the fine-mapping, genotype data from the African American studies were analyzed jointly with data from European (n = 7196 cases, 7275 controls) and Asian (n = 3901 cases, 3205 controls) studies. In the combined analysis, SNP rs2981578 was the most strongly associated. Five other SNPs were too strongly correlated to be excluded at a likelihood ratio of < 1/100 relative to rs2981578. Analysis of DNase I hypersensitive sites indicated that only two of these map to highly accessible chromatin, one of which, SNP rs2981578, has previously been implicated in up-regulating FGFR2 expression. Our results demonstrate that the association of SNPs in FGFR2 with BC risk extends to women of African American ethnicity, and illustrate the utility of combining association analysis in datasets of diverse ethnic groups with functional experiments to identify disease susceptibility variants.</P>