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Extract Function Clone Genealogies across Multiple Versions
Tu Ying,Zhang Li-ping,Wang Chun-Hui,Liu Dong-sheng 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.6
Software systems often contain plenty of code clones, which bring significant impact on software development and maintenance. Tracking clones in the evolution process is essential to analyzing clones, since we cannot understand clone phenomenon well just rely on the clone detection results of single version. We developed a function clone genealogy extractor, cGen, which can track clones across multiple versions to extract type-1 and type-2 function clone genealogies. By using cGen, we examine nine open source C projects and analyze their evolution. Our study shows that cGen can efficiently extract clone genealogies from multiple versions of a project, and provide support for clone evolution analysis.
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Extracting Clone Genealogies for Tracking Code Clone Changes
Chun-Hui Wang,Ying Tu,,Li-Ping Zhang,Dong-Sheng Liu 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.3
Software system’s clones are usually two aspects influence on software maintenance and management. One is some clones are effective and can reuse. The other is some clones are unsafe and need revise or reconfiguration. The reason is that the changes of code clones are different. How to determine the clones' attribute of effective or unsafe, it need to track clone changes in the evolution versions of a software system. We firstly find the clones and clone groups in multiple versions of a software system using a clone detector FCD, and construct the mapping of every adjacent version basing on the similarity of code clones, then extract clone genealogies in the software system. The clone genealogies’ results are efficient and can help us analysis the code clone changes and get the attribute about effective and unsafe.
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( Jianhua Liang ),( Hui Qu ),( Xiaowen Wang ),( Aiping Wang ),( Lingling Liu ),( Ping Tu ),( Ruoyu Li ),( Mingyue Wang ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.1
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction characterized by maculopapular rash, exfoliative dermatitis, lymphadenopathy, fever, eosinophilia, and involvement of internal organs. Evidence for reactivation of herpes family viruses has been observed in some DRESS patients, and activated CD8+ T lymphocytes are largely directed against Epstein-Barr virus. Here, we report two cases complicated with this infection. Both patients received antibiotics and non-steroidal anti-inflammatory drugs. These patients manifested clinically with high fever, facial edema, diffuse pruritic erythroderma and maculopapules over the entire body, purpuric rashes in both lower limbs and lymphadenopathy of cervical and inguinal nodes. Laboratory tests revealed abnormal liver function, blood eosinophils, and ferritin levels. The patients recovered completely; however, the female patient developed hemophagocytic syndrome on the 15th day of illness. She developed new itchy rash, and laboratory tests rapidly worsened with fibrinogen levels dramatically reduced to 0.61 g/L. Bone marrow aspiration revealed an increased number of macrophages with hemophagocytosis and a reversed CD4/CD8 ratio of 0.45. These cases suggest that human herpes virus and coagulation function evaluations are necessary in DRESS patients. (Ann Dermatol 30(1) 71∼74, 2018)
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Sohng, Hee Yon,Kuniyuki, Alan,Edelson, Jane,Weir, Rosy Chang,Song, Hui,Tu, Shin-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Understanding and enhancing change capabilities, including Practice Adaptive Reserve (PAR), of Community Health Centers (CHCs) may mitigate cancer-related health disparities. Materials and Methods: Using stratified random sampling, we recruited 232 staff from seven CHCs serving Asian Pacific Islander communities to complete a self-administered survey. We performed multilevel regression analyses to examine PAR composite scores by CHC, position type, and number of years worked at their clinic. Results: The mean PAR score was 0.7 (s.d. 0.14). Higher scores were associated with a greater perceived likelihood that clinic staff would participate in an evidence-based intervention (EBI). Constructs such as communication, clinic flow, sensemaking, change valence, and resource availability were positively associated with EBI implementation or trended toward significance. Conclusions: PAR scores are positively associated with perceived likelihood of clinic staff participation in cancer screening EBI. Future research is needed to determine PAR levels most conducive to implementing change and to developing interventions that enhance Adaptive Reserve.
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TSHR Variant Screening and Phenotype Analysis in 367 Chinese Patients With Congenital Hypothyroidism
Zhang Hai-Yang,Wu Feng-Yao,Li Xue-Song,Tu Ping-Hui,Zhang Cao-Xu,Yang Rui-Meng,Cui Ren-Jie,Wu Chen-Yang,Fang Ya,Yang Liu,Song Huai-Dong,Zhao Shuang-Xia 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.4
Background: Genetic defects in the human thyroid-stimulating hormone (TSH) receptor (TSHR) gene can cause congenital hypothyroidism (CH). However, the biological functions and comprehensive genotype–phenotype relationships for most TSHR variants associated with CH remain unexplored. We aimed to identify TSHR variants in Chinese patients with CH, analyze the functions of the variants, and explore the relationships between TSHR genotypes and clinical phenotypes. Methods: In total, 367 patients with CH were recruited for TSHR variant screening using whole-exome sequencing. The effects of the variants were evaluated by in-silico programs such as SIFT and polyphen2. Furthermore, these variants were transfected into 293T cells to detect their Gs/cyclic AMP and Gq/11 signaling activity. Results: Among the 367 patients with CH, 17 TSHR variants, including three novel variants, were identified in 45 patients, and 18 patients carried biallelic TSHR variants. In vitro experiments showed that 10 variants were associated with Gs/cyclic AMP and Gq/11 signaling pathway impairment to varying degrees. Patients with TSHR biallelic variants had lower serum TSH levels and higher free triiodothyronine and thyroxine levels at diagnosis than those with DUOX2 biallelic variants. Conclusions: We found a high frequency of TSHR variants in Chinese patients with CH (12.3%), and 4.9% of cases were caused by TSHR biallelic variants. Ten variants were identified as loss-of-function variants. The data suggest that the clinical phenotype of CH patients caused by TSHR biallelic variants is relatively mild. Our study expands the TSHR variant spectrum and provides further evidence for the elucidation of the genetic etiology of CH.
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