The roles of ARID1A in gynecologic cancer

Tsui-Lien Mao,Ie-Ming Shih 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4

One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of chromatin remodeling in the pathogenesis of human cancer but also provide molecular genetic basis of aberrant epigenomic regulation as one of the key mechanisms driving cancer development. This is because chromatin remodeling influences a variety of DNA activities such as replication, transcription, repair, methylation, and recombination. Among the mutated chromatin remodeling genes reported, ARID1A is frequently mutated in a variety of human cancers, especially in endometrium-related neoplasms including ovarian clear cell carcinoma, ovarian endometrioid carcinomas, and uterine endometrioid carcinomas, all of which arise from endometrial epithelium. This review will summarize the recent advances in studying the roles of ARID1A mutations in gynecologic cancers with special emphasis on how this new knowledge will further extend our understanding of the pathogenesis of endometrium-related carcinomas.

Utilizing Post-partum Caring Model to Improve Stillbirth Postpartum Maternal of the Nursing Completion Rate

Tsui-Ling Chen,Pi-Feng Hsu 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

Fast Discovery of Frequent Itemsets through Clustering and Decomposition

Tsui-Ping Chang 한국산학기술학회 2012 SmartCR Vol.2 No.6

In a previous paper, we proposed a technique called the top-down mining (TDM) algorithm to speed up the task of mining hybrid sequential patterns. TDM has a unique feature that examines database itemsets in a top-down manner using decomposition. This method, however, may incur a space problem during decomposition transactions from the database. In this paper, therefore, we propose a new algorithm called transaction decomposition with clustering (TDC) to alleviate the space problem associated with the decomposition method. We use TDC to derive frequent itemsets from a large database. The major feature of TDC is that it divides a database into several smaller projected databases such that each portion can be solved with the decomposition method independently. Since a large amount of information does not have to be stored in memory, the TDC method can efficiently mine frequent itemsets. We compare experimental results for the proposed method and existing algorithms. The results show that TDC can solve the space problem of TDM, and TDC outperforms its counterpart algorithms in many cases. Even when the data set is large or the user-specified minimum support is low, the TDC method still exhibits high performance in mining frequent itemsets. This makes the TDC method suitable for mining frequent itemsets in very large databases.

Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues To Regulate Skeletal Muscle Maturation and Vascularization

Tsui, Jonathan H.,Janebodin, Kajohnkiart,Ieronimakis, Nicholas,Yama, David M. P.,Yang, Hee Seok,Chavanachat, Rakchanok,Hays, Aislinn L.,Lee, Haeshin,Reyes, Morayma,Kim, Deok-Ho American Chemical Society 2017 ACS NANO Vol.11 No.12

<P>Despite possessing substantial regenerative capacity, skeletal muscle can suffer from loss of function due to catastrophic traumatic injury or degenerative disease. In such cases, engineered tissue grafts hold the potential to restore function and improve patient quality of life. Requirements for successful integration of engineered tissue grafts with the host musculature include cell alignment that mimics host tissue architecture and directional functionality, as well as vascularization to ensure tissue survival. Here, we have developed biomimetic nanopatterned poly(lactic-<I>co</I>-glycolic acid) substrates conjugated with sphingosine-1-phosphate (S1P), a potent angiogenic and myogenic factor, to enhance myoblast and endothelial maturation. Primary muscle cells cultured on these functionalized S1P nanopatterned substrates developed a highly aligned and elongated morphology and exhibited higher expression levels of myosin heavy chain, in addition to genes characteristic of mature skeletal muscle. We also found that S1P enhanced angiogenic potential in these cultures, as evidenced by elevated expression of endothelial-related genes. Computational analyses of live-cell videos showed a significantly improved functionality of tissues cultured on S1P-functionalized nanopatterns as indicated by greater myotube contraction displacements and velocities. In summary, our study demonstrates that biomimetic nanotopography and S1P can be combined to synergistically regulate the maturation and vascularization of engineered skeletal muscles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2017/ancac3.2017.11.issue-12/acsnano.7b00186/production/images/medium/nn-2017-001868_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn7b00186'>ACS Electronic Supporting Info</A></P>

WELFARE EFFECTS AND OPTIMAL INCENTIVE PACKAGE OF EXPORT PROCESSING ZONES

TSUI, KAI YUEN 한국국제경제학회 1993 International Economic Journal Vol.7 No.2

This paper introduces bargaining as an organizing framework to study the welfare effects of export processing zones in a distortion-ridden open economy with Harris-Todaro type unemployment. General guidelines for the design of optimal incentive package are explored. [F21]

State Capacity in City Planning: The Reconstruction of Nanjing, 1927-1937

Carmen Tsui 고려대학교 민족문화연구원 2011 Cross-Currents Vol.- No.1

After reunifying China in 1927, the Nationalist government proposed a comprehensive planning proposal, the Capital Plan (shoudu jihua), to reconstruct the war-torn city of Nanjing into a modern capital, despite the fact that the infant republic was still threatened by internal strife and external aggression. This article discusses the complex politics involved in the reconstruction of Nanjing from 1927 to 1937, illustrating the way in which the Nationalist state tried to transform China’s urban development. It focuses on why unified planning ideas could not be generated during the planning process, and why these ideas did not turn fully into practice during the implementation process. By studying the aborted effort in planning Nanjing, knowing in what particular dimensions the state excelled and in what other dimensions things went wrong, this article analyzes the unevenness of state capacity in Republican China.

중공군의 한국전쟁 참전(Ⅷ)

David Tsui 한국전략문제연구소 2008 전략연구 Vol.- No.42

중공군의 한국전쟁 참전(Ⅻ)

David Tsui 한국전략문제연구소 2009 전략연구 Vol.- No.46

중공군의 한국전쟁 참전(ⅩⅣ)

David Tsui(데이빗 쑤이) 한국전략문제연구소 2010 전략연구 Vol.- No.48

The Evidence-Oriented Crime Control Policy : An Analysis of Police Data and Public Opinion in Taiwan

Huang Tsui-Wen,Mon Wei-Teh 아시아경찰학회 2004 Asia Pacific Journal of Police & Criminal Justice Vol.2 No.1

  Good social order is an important condition for human living. People are happy to live in the circumstances of no or less fear of crime victimization. The purpose of this study is to explore an evidence-oriented and feasible crime control policy for local government and citizens. The research setting for this study is located in Taipei county, the largest county both in terms of overall population and population density ( 3.51 million, population density 1,711 per square kilometer ) in Taiwan. Furthermore, Taipei county covers approximately 2,052 square kilometers and can be divided into urbanized, rural, coastal and mountainous areas. In general, Taipei county can represent the typical features of Taiwan’s geography.<BR>  In order to achieve the purpose of this research, data were collected through qualitative and quantitative approaches. There are four major sources of data on crimes of Taipei county-the ten-year statistics on crimes collected from the Taipei County Police Department(TCPD), focus group interviews(to investigate and comprehend the police officers’ recognition and viewpoint of the content of the public need for social order and suitable crime control policy), analysis of the 109,351 citizen calls to which the police officers of TCPD were dispatched from year 1999 to 2000, and public opinion survey(including 3,026 respondents in the sample).<BR>  According to the analysis of empirical data collected in this research, the crime control policy was yielded as the following items:<BR>  1.Increasing police patrol density.<BR>  2.Imposing stronger control on hot spots of crime.<BR>  3.More law enforcement on traffic violation.<BR>  4.Improving police service quality.<BR>  5.Implementing community policing.<BR>  6.Strengthening the function of community and apartment managing committee.<BR>  7.Increasing the police forces.<BR>  8.Innovating the police training and education program.