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- 저자 : Toru Oshima (검색결과 2 건)
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Sekijima Hidehisa,Oshima Toru,Ueji Yuno,Kuno Naoko,Kondo Yukino,Nomura Saera,Asakura Tomomi,Sakai-Sugino Kae,Kawano Mitsuo,Komada Hiroshi,Kotani Hirokazu 한국독성학회 2023 Toxicological Research Vol.39 No.3
Benzalkonium chloride (BAC) intoxication causes fatal lung injuries, such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the pathogenesis of ALI/ARDS induced by BAC ingestion is poorly understood. This study aimed to clarify the mechanism of lung toxicity after BAC ingestion in a mouse model. BAC was orally administered to C57BL/6 mice at doses of 100, 250, and 1250 mg/kg. After administration, BAC concentrations in the blood and lungs were evaluated via liquid chromatography with tandem mass spectrometry. Lung tissue injury was evaluated via histological and protein analyses. Blood and lung BAC concentration levels after oral administration increased in a dose-dependent manner, with the concentrations directly proportional to the dose administered. The severity of lung injury worsened over time after the oral administration of 1250 mg/kg BAC. An increase in the terminal transferase dUTP nick end labeling-positive cells and cleaved caspase-3 levels was observed in the lungs after 1250 mg/kg BAC administration. In addition, increased cleaved caspase-9 levels and mitochondrial cytochrome c release into the cytosol were observed. These results suggest that lung tissue injury with excessive apoptosis contributes to BAC-induced ALI development and exacerbation. Our findings provide useful information for developing an effective treatment for ALI/ARDS induced by BAC ingestion.
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Modeling of an ER Fluid’s Time Delay for Servo Systems
Tomohiro Terada,Ken’ichi Koyanagi,Toru Oshima 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
A particle type ER(Electro-Rheological) fluid damper in which viscosity was controlled for fast and precise positioning control have been developed in aprevious study. However, for improvement of control performance or new control demands of mechatronics devices using particle type ER fluids, it will be needed to further investigate are sponse time of the fluids. It is commonly said around 5-milliseconds, but, the formula structure of that delay has not been clear. This study aims to develop a functional damper(attenuators), that can control its viscous characteristics in real time using ER fluids as its working fluid. ER dampers in this case are useful to a ccomplish high precision positioning not to prevent high speed movement of the motor. To realize the functional damper that can be manipulated according to situation sortasks, the modeling and control of ER fluids are necessary. This paper investigates time delay affects of ER fluids and makes an in-depth dynamic model of the fluid by utilizing simulation and experiment. The mathematical model has a dead-time and first ordered delays of the fluid and the high voltage amplifier for the fluid.
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