Synthesis, Characterizations, and Intramolecular Quenching Behavior of an Axially-Linked Trinuclear Molecular Wire Containing Ruthenium(II) Porphycenes

Abe, Masaaki,Ashigara, Shiho,Okawara, Toru,Hisaeda, Yoshio Korean Society of Photoscience 2015 Rapid communication in photoscience Vol.4 No.1

A new trinuclear complex $[Ru(TPrPc)(CO)]_2[Ru(pytpy)_2](PF_6)_2$ (TPrPc = 2,7,12,17-tetra-n-propylporphycenato dianion and pytpy = 4'-(4-pyridyl)-2,2':6',2"-terpyridine) has been synthesized and characterized as the first example of a discrete molecular wire containing metalloporohycenes as a building block. The trinuclear complex shows multiple-step redox behavior in 0.1 M n-$Bu_4NPF_6$-dichloromethane. The mononuclear $[Ru(pytpy)_2]^{2+}$ precursor shows emission at 640 nm (deaerated acetone, 298 K) upon illumination at the metal-to-ligand charge transfer (MLCT) band at 495 nm, but the trinuclear molecular wire is found to be non-emissive upon photoexcitation at the central $[Ru(pytpy)_2]^{2+}$ entity, indicating an efficient quenching ability of the axially-linked, ruthenium(II)-porphycene chromophores in an intramolecular fashion.

Different Associations of Plasma Biomarkers in Alzheimer’s Disease, Mild Cognitive Impairment, Vascular Dementia, and Ischemic Stroke

Jingwei Shang,Toru Yamashita,Yusuke Fukui,Dongjing Song,Xianghong Li,Yun Zhai,Yumiko Nakano,Ryuta Morihara,Nozomi Hishikawa,Yasuyuki Ohta,Koji Abe 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.1

Background and Purpose Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. Methods The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer’s disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130). Results The serological data showed that lower EPA and DHA levels and higher reptin and LDL levels were associated with AD and IS, the reptin/adiponectin ratio was strongly associated with IS, the hsCRP level was more strongly associated with VaD and IS, and the serum AA level was associated with all three cognitive diseases and IS. Conclusions This is the first report of differences in the expression levels of plasma biomarkers and peripheral arterial tonometry among AD, MCI, VaD, and IS patients and normal controls. These different associations indicate that diverse pathological mechanisms underlie these diseases

Elevated Levels of Serum Pentosidine Are Associated with Dropped Head Syndrome in Older Women

Yawara Eguchi,Toru Toyoguchi,Kazuhide Inage,Kazuki Fujimoto,Sumihisa Orita,Kazuyo Yamauchi,Miyako Suzuki,Hirohito Kanamoto,Koki Abe,Masaki Norimoto,Tomotaka Umimura,Masao Koda,Takeo Furuya,Yasuchika A 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.1

Study Design: A retrospective observational study was performed. Purpose: We investigated the prevalence of sarcopenia in dropped head syndrome (DHS), and the relationship between biochemical markers, including major advanced glycation end products (AGEs), pentosidine, and DHS in older women. Overview of Literature: AGEs have been implicated in the pathogenesis of sarcopenia. Methods: We studied 13 elderly women with idiopathic DHS (mean age, 77.2 years) and 20 healthy volunteers (mean age, 74.8 years). We used a bioelectrical impedance analyzer to analyze body composition, including appendicular skeletal muscle mass index (SMI; appendicular lean mass [kg]/[height (m)]2). Cervical sagittal plane alignment, including C2–C7 sagittal vertical axis (C2–C7SVA), C2–C7 angle, and C2 slope (C2S), was measured. Biochemical markers, such as serum and urinary pentosidine, serum homocysteine, 1, 25-dihydroxyvitamin D, and 25-hydroxyvitamin D, were measured. The level of each variable was compared between DHS and controls. The relationship between biochemical markers and DHS was examined. Results: Sarcopenia (SMI <5.75) was observed at a high prevalence in participants with DHS (77% compared to 22% of healthy controls). Height, weight, femoral bone mineral density, appendicular lean mass, total lean mass, and SMI all had significantly lower values in the DHS group. Serum and urinary pentosidine, and serum homocysteine were significantly higher in the DHS group compared to controls. Analysis of cervical alignment revealed a significant positive correlation of serum pentosidine with C2–C7SVA and C2S. Conclusions: Sarcopenia was involved in DHS, and high serum pentosidine levels are associated with severity of DHS in older women.

A Classifiable Sub-Flow Selection Method for Traffic Classification in Mobile IP Networks

( Akihiro Satoh ),( Toshiaki Osada ),( Toru Abe ),( Gen Kitagata ),( Norio Shiratori ),( Tetsuo Kinoshita ) 한국정보처리학회 2010 Journal of information processing systems Vol.6 No.3

Traffic classification is an essential task for network management. Many researchers have paid attention to initial sub-flow features based classifiers for traffic classification. However, the existing classifiers cannot classify traffic effectively in mobile IP networks. The classifiers depend on initial sub-flows, but they cannot always capture the sub-flows at a point of attachment for a variety of elements because of seamless mobility. Thus the ideal classifier should be capable of traffic classification based on not only initial sub-flows but also various types of sub-flows. In this paper, we propose a classifiable sub-flow selection method to realize the ideal classifier. The experimental results are so far promising for this research direction, even though they are derived from a reduced set of general applications and under relatively simplifying assumptions. Altogether, the significant contribution is indicating the feasibility of the ideal classifier by selecting not only initial sub-flows but also transition sub-flows.

A Classifiable Sub-Flow Selection Method for Traffic Classification in Mobile IP Networks

Satoh, Akihiro,Osada, Toshiaki,Abe, Toru,Kitagata, Gen,Shiratori, Norio,Kinoshita, Tetsuo Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.3

Traffic classification is an essential task for network management. Many researchers have paid attention to initial sub-flow features based classifiers for traffic classification. However, the existing classifiers cannot classify traffic effectively in mobile IP networks. The classifiers depend on initial sub-flows, but they cannot always capture the sub-flows at a point of attachment for a variety of elements because of seamless mobility. Thus the ideal classifier should be capable of traffic classification based on not only initial sub-flows but also various types of sub-flows. In this paper, we propose a classifiable sub-flow selection method to realize the ideal classifier. The experimental results are so far promising for this research direction, even though they are derived from a reduced set of general applications and under relatively simplifying assumptions. Altogether, the significant contribution is indicating the feasibility of the ideal classifier by selecting not only initial sub-flows but also transition sub-flows.

Successful Use of the Hybrid Assistive Limb for Care Support to Reduce Lumbar Load in a Simulated Patient Transfer

Miura Kousei,Kadone Hideki,Abe Tetsuya,Koda Masao,Funayama Toru,Noguchi Hiroshi,Kumagai Hiroshi,Nagashima Katsuya,Mataki Kentaro,Shibao Yosuke,Sato Kosuke,Kawamoto Hiroaki,Sankai Yoshiyuki,Yamazaki Ma 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.1

Study Design: Prospective experimental study in humans.Purpose: To determine whether the hybrid assistive limb (HAL) for Care Support can reduce lumbar load during a patient transfer.Overview of Literature: The prevalence of work-related low back pain (LBP) among nurses is high. In particular, transferring patients poses a high risk for LBP due to the large lumbar load. Attempts to reduce the lumbar load are crucial to avoid the risk of LBP. Therefore, we investigated the effects of the HAL for Care Support.Methods: Nineteen volunteers (16 men, three women) lifted a 60-kg doll from a seated position to a standing position. The first transfer was performed without the HAL for Care Support, and the second was performed with the HAL for Care Support assistive robot. We evaluated transfer performance, the visual analog scale (VAS) score for lumbar fatigue, and electromyogram analyses of the trunk and hip.Results: Four participants (two men, two women) succeeded with the HAL for Care Support even though they were unable to perform the task without it. The mean lumbar fatigue VAS score for all participants without the HAL for Care Support was 62 mm, while that with it was 43 mm. With lumbar assistance from the HAL for Care Support, subjective lumbar fatigue during the transfer decreased significantly. A power analysis indicated adequate statistical power to detect a difference in the VAS score for lumbar fatigue (0.99). The activity of the left gluteus maximus alone increased significantly during transfers with the HAL for Care Support. No adverse events occurred during use of the HAL for Care Support for transfers.Conclusions: The HAL for Care Support was able to reduce lumbar load in a simulated patient transfer.

A Design of Port Scan Detection Method Based on the Characteristics of Packet-In Messages in OpenFlow Networks

Daichi Ono,Satoru Izumi,Toru Abe,Takuo Suganuma 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09

Due to the diversification of devices and the spread of the Internet, many people are handling information over the network and the threat of cyber-attacks by unauthorized access and malware is also considered as a problem, and countermeasures against these threats are an urgent issue. SDN and OpenFlow are useful for network cybersecurity counter-measures because they can collect traffic statistics from switches and can interrupt communication at the switch level. In this study, we focus on detecting a port scanning as a preparation stage for cyber-attacks. In this paper, we propose port scan detection method based on the characteristics of Packet-In messages in an OF network. Also, we show its effectiveness through the experiments.

Tumor Occupation in the Spinal Canal and Clinical Symptoms of Cauda Equina Schwannoma: An Analysis of 22 Cases

Kengo Fujii,Masataka Sakane,Tetsuya Abe,Tsukasa Nakagawa,Shinsuke Sakai,Masaki Tatsumura,Toru Funayama,Masashi Yamazaki 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.6

Study Design: Retrospective, radiological study. Purpose: To determine the relationship between clinical symptoms and the extent of tumor occupation of the spinal canal by cauda equina schwannoma. Overview of Literature: Little is known about the relationship between the size of tumors of the cauda equina and the manifestation of clinical symptoms. We analyzed this relationship by estimating the percentage of tumor occupation (PTO) in the spinal canal in cauda equina schwannomas and by correlating this parameter with the presence and severity of clinical symptoms. Methods: Twenty-two patients (9 men and 13 women; age, 19–79 years; mean age, 55.3 years) who were radiologically diagnosed with schwannomas of the cauda equina between April 2004 and July 2014 were retrospectively analyzed. PTO was measured in axial and sagittal magnetic resonance imaging slices in which the cross-sectional area of the tumor was the largest. Data regarding clinical symptoms and results of physical examinations were collected from patient medical records. PTO differences between symptompositive and -negative groups were analyzed for each variable. Results: In the 4 cases in which tumor presence was not related to clinical symptoms, PTO was 5%–10% (mean, 9%) in axial slices and 23%–31% (mean, 30%) in sagittal slices. In the 18 cases in which symptoms were associated with the tumor, PTO was 11%–86% (mean, 50%) in axial slices and 43%–88% (mean, 71%) in sagittal slices. PTO in axial slices was significantly higher in the presence of Déjèrine symptoms and/or muscle weakness, a positive straight leg raise test, and a positive Kemp sign. Conclusions: PTO >20% in axial slices and >40% in sagittal slices can be an indication of symptomatic cauda equina schwannoma.

Poster Session:PS 0563 ; Palliative Care : Transient Elastography (fi broscan) for Early Detection and Assessment of Liver Fibrosis and Liver Stiffness Caused by HCV Co-Infection in HIV-Positive Patient

( Yoichi Yano ),( Tatsuyuki Tonan ),( Yuriko Koga ),( Toru Nakamura ),( Mitsuhiko Abe ),( Yu Ikezono ),( Michio Sata ),( Takuji Torimura ),( Si Won Lee ),( Mi Hong Choi ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Liver stiffness is sometimes occured in patient with HCV-associated to HIV-positive. Reduction of immune system, the patient might has been got HCV easily. Early detection and treatment should be done to ensure that the patient can be healed. The earlier we can detect, the higher possibility they can be cured. Therefore, nowadays researchers and clinicians focused in the development of diagnostic tools with high sensitivity and specifi city. The noninvasive measurement of liver stiffness (LS) now can be evaluated by transient elastography (fibroScan). Methods: We evaluated 35 patients with chronic viral hepatitis, 69% were male, 31% were female. We divided them into 3 groups, (1) no fi brosis group (2) mild until moderate (3) severe HCV with extensive fi brosis and liver stiffness. All subject (100%) were evaluated by fibroScan, 15 patients (43%) also got liver biopsy, and 31 patients (88%) also got MRI. Study design is cross-sectional with simple random sampling. Results: In TE, the degree of liver fi brosis were calculated by velocity of low-frequency transient wave produced by mechanical-probe. Comparing to liver biopsy, TE has demonstrated both high specifi city and sensitifi ty. The specifi cty of TE is 94.29% to (95%CI: 93.15%-96.7%) and sensitifi ty of TE is 82.85% (95% CI: 79,87%-85,76%). Conclusions: Real-time TE is a reliable surrogate marker of liver fi brosis, with high specifi city and sensitifi ty for early detection in mild fi brosis. However, the applicability of TE is limited to non-obese patients (BMI < 30 kg/m2) and without any ascites. If TE has already predicted liver fi brosis, biposy may not be necessary.

Freeze-Dried Human Platelet-Rich Plasma Retains Activation and Growth Factor Expression after an Eight-Week Preservation Period

Yasuhiro Shiga,Go Kubota,Sumihisa Orita,Kazuhide Inage,Hiroto Kamoda,Masaomi Yamashita,Toru Iseki,Michihiro Ito,Kazuyo Yamauchi,Yawara Eguchi,Takeshi Sainoh,Jun Sato,Kazuki Fujimoto,Koki Abe,Hirohito 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.3

Study Design: Controlled laboratory study. Purpose: This study aimed to evaluate the efficacy of platelet-rich plasma (PRP) stored at room temperature (RT), frozen, or after freeze-drying. Overview of Literature: PRP enriches tissue repair and regeneration, and is a novel treatment option for musculoskeletal pathologies. However, whether biological activity is preserved during PRP storage remains uncertain. Methods: PRP was prepared from blood of 12 healthy human volunteers (200 mL/person) and stored using three methods: PRP was stored at RT with shaking, PRP was frozen and stored at –80°C, or PRP was freeze-dried and stored at RT. Platelet counts and growth factor content were examined immediately after preparation, as well as 2, 4, and 8 weeks after storage. Platelet activation rate was quantified by flow cytometry. Results: Platelet counts were impossible to determine in many RT samples after 2 weeks, but they remained at constant levels in frozen and freeze-dried samples, even after 8 weeks of storage. Flow cytometry showed approximately 80% activation of the platelets regardless of storage conditions. Almost no growth factors were detected in the RT samples after 8 weeks, while low but significant expression was detected in the frozen and freeze-dried PRP. Over time, the mean relative concentrations of various growth factors decreased significantly or disappeared in the RT group. In the frozen group, levels were maintained for 4 weeks, but decreased significantly by 8 weeks (p <0.05). The freeze-dried group maintained baseline levels of growth factors for the entire 8-week duration. Conclusions: Freeze-drying enables PRP storage while maintaining bioactivity and efficacy for extended periods.