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- 저자 : Tobi Ferguson (검색결과 1 건)
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Sensory Axon Regeneration: A Review from an in vivo Imaging Perspective
한승백,Young-Jin Son,김혁민,Andrew Skuba,Alan Tessler,Tobi Ferguson 한국뇌신경과학회 2012 Experimental Neurobiology Vol.21 No.3
Injured primary sensory axons fail to regenerate into the spinal cord, leading to chronic pain and permanent sensory loss. Re-entry is prevented at the dorsal root entry zone (DREZ), the CNS-PNS interface. Why axons stop or turn around at the DREZ has generally been attributed to growth-repellent molecules associated with astrocytes and oligodendrocytes/myelin. The available evidence challenges the contention that these inhibitory molecules are the critical determinant of regeneration failure. Recent imaging studies that directly monitored axons arriving at the DREZ in living animals raise the intriguing possibility that axons stop primarily because they are stabilized by forming presynaptic terminals on non-neuronal cells that are neither astrocytes nor oligodendrocytes. These observations revitalized the idea raised many years ago but virtually forgotten, that axons stop by forming synapses at the DREZ.
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