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RISS 인기검색어
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- 저자 : Tkaczuk, Cezary (검색결과 2 건)
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Kleespies, Regina G.,Lim, Young Woon,Tkaczuk, Cezary,Wrzosek, Marta,Steinwender, Bernhardt M.,Wegensteiner, Rudolf Elsevier 2017 Journal of invertebrate pathology Vol.143 No.-
<P><B>Abstract</B></P> <P> <I>Ips sexdentatus</I> (six-spined engraver beetle) from Austria and Poland were dissected and examined for the presence of pathogens. Specimens collected in Austria were found to contain the ascomycetous fungus <I>Metschnikowia</I> cf. <I>typographi</I>. Infection rates ranged from 3.6% to 26.8% at different collection sites. <I>M.</I> cf. <I>typographi</I> infected midguts were investigated by histological, ultrastructural and molecular techniques. Extraordinary ultrastructural details are shown, such as ascospores with bilateral flattened flanks resembling alar rims at both sides of their attenuating tube-like ends. These have not yet been described in other yeast species. Molecular investigations showed a close phylogenetic relationship to the fungi <I>Metschnikowia agaves</I> and <I>Candida wancherniae</I>. Presence of the entomopathogenic fungus <I>Beauveria bassiana</I> found in Austria was confirmed both morphologically and molecularly. The eugregarine <I>Gregarina typographi</I> was diagnosed most frequently. Infection rates of all <I>I. sexdentatus</I> specimens ranged from 21.4% to 71.9% in Austria and 54.1% to 68.8% in Poland. Other entomopathogenic protists, bacteria, or viruses were not detected.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Prevalence of <I>Metschnikowia</I> cf. <I>typographi</I> in <I>Ips sexdentatus</I> is described. </LI> <LI> Extraordinary ultrastructural details of <I>M.</I> cf. <I>typographi</I> are shown first with TEM. </LI> <LI> Phylogenetic relationship of <I>M.</I> cf. <I>typographi</I> is presented. </LI> <LI> Close relationship to <I>Metschnikowia agaves</I> and <I>Candida wancherniae</I> is shown. </LI> <LI> <I>Gregarina typographi</I> was diagnosed most frequently in Austria and Poland. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Lucie F Calderon,Meredith Kline,Marc Hersh,Kevin P Shah,Suprateek Kundu,Andrew Tkaczuk,Nancy McColloch,Anand S Jain 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3
Background/AimsThe mechanism via which supra-esophageal symptoms are generated is unclear. We assessed upper esophageal sphincter (UES) function in novel fashion using functional lumen imaging probe (FLIP) topography. We hypothesize that symptoms related to aspiration of esophageal contents may be associated with a more distensible UES. MethodsFLIP and reflux symptom index score data from patients undergoing diagnostic evaluation for an esophageal complaint over a 10-month period were analyzed retrospectively. UES distensibility on FLIP was studied at 40-70 mL volumes with in-depth analysis at 50 and 60 mL. Symptoms were compared between patients with low, middle, and high UES-distensibility index (UES-DI). Receiver-operating characteristic analysis was performed to determine associations between the UES-DI and individual reflux symptom index symptom item scores. ResultsOne hundred and eleven subjects were included. Overall, the associations between UES-DI and symptoms that could be related to supra-esophageal aspiration were strongest at the 50 mL FLIP volume. Choking item score was highest in the high UES-DI group (2.8) vs 1.4 (P < 0.001) in the middle UES-DI and 1.1 (P = 0.004) in the low UES-DI groups. Similarly, the cough item score was highest in the high UES-DI group (2.7) vs 1.5 (P = 0.009) and 0.9 (P = 0.002) groups. ConclusionA higher UES-DI measures defective barrier function which could may be the main pathophysiology that generates supra-esophageal symptoms.
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