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Yuping Zhu,Suzhen Zhai,Bei Li,Ziyi Zhao,Jiao Xie,Tingyuan Ren 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
To explore hypoglycemic effect of wild Rosa roxburghii tratt (RRT) juice at different altitudes on type 1diabetes mellitus (T1DM). The T1DM mouse model was induced by streptozotocin (STZ), and the experiment included anormal group (NC), model group (MC), wild RRT juice groups high (HF), medium (MF), low altitude (DF) and cultivatedcontrol group (PC). During experiment, food intake, water intake, body weight, and fasting blood glucose were measured. After 28 days of administration, glucose tolerance, glycogen level, lipid profiles, and antioxidation levels in serum and liverwere measured, and histomorphological changes of liver and kidney were observed by hematoxylin and eosin staining. The results showed that wild RRT juice reduced blood glucose level, alleviated liver and kidney tissue damage, improvedglucose and lipid metabolism disorders and attenuated oxidative damage in T1DM mice. Western blot showed that wild RRTjuice at grown at different altitudes significantly increased protein abundance of PI3K, Akt, and GLUT2 in liver of T1DMmice. In conclusion, wild RRT juice from different altitudes improved glucose and lipid metabolism disorders and oxidativedamage in T1DM mice, which may be attributed to activation of PI3K/Akt pathway. Overall effect: MF > PC > HF > DF.