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        A Model of Coupled Flow in Impeller and Volute of a Single Stage Centrifugal Pump with Interaction of Impeller-Tongue Gap Flow

        Runmei Ma,Tianxin Ma 한국유체기계학회 2020 International journal of fluid machinery and syste Vol.13 No.4

        The impeller-volute interaction flow in centrifugal pump is influenced by the flow in impeller-tongue gap. In order to completely understand the mechanism of interaction between impeller-volute flow and impeller-tongue gap flow, a transient three-dimensional numerical simulation of the flow in a single stage centrifugal pump was carried out by applying sliding mesh approach and the standard k-ε turbulence model in CFD, and the derived transient flow data were time-averaged over a period of one blade passing the tongue. The analysis of the flow in the pump revealed that under off-design conditions, a reversed flow with lower pressure at small flowrates below the dutypoint or a stagnation region with higher pressure at high flowrates above the dutypoint appeared in the near tongue region in volute, which enhanced the asymmetric flow in impeller channels. It was consequently considered that the flow in impeller-tongue gap was a superposition of a drag flow by impeller and a pressure leakage flow driven by pressure difference between two sides of the tongue, and the pressure difference was zero at design condition, but increased with the deviation degree of the flow in impeller from the dutypoint. Under smaller flowrates, the gap leakage flow has direction opposite to that at higher flowrates, and affects much the volute flow. In the end, based on the analytical results, a semi-empirical model for the volute flow was deduced by one-dimensional flow continuity, and it may supply a reference for optimizing the flow in volute.

      • Association Between MDM2 SNP309 T>G and Risk of Gastric Cancer: A Meta-analysis

        Tian, Xin,Tian, Ye,Ma, Ping,Sui, Cheng-Guang,Meng, Fan-Dong,Li, Yan,Fu, Li-Ye,Jiang, Tao,Wang, Yang,Ji, Fu-Jian,Fang, Xue-Dong,Jiang, You-Hong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

        Background: As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer. Methods: The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases. Results: It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected. Conclusion: The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.

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