Factors Affecting the Development of Vietnamese Construction and Real Estate Companies

Giang Lam PHAN(Giang Lam PHAN ),Thuy Dieu NGUYEN(Thuy Dieu NGUYEN ),Chi Thi NGUYEN(Chi Thi NGUYEN ),Lan NGUYEN(Lan NGUYEN ),Le Thi TRAN(Le Thi TRAN ) 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.9

This study aims to investigate the factors that contribute to the sustainable development of 334 Vietnamese construction and real estate companies listed on the Stock Exchange of Vietnam over a 5-year period from 2016 to 2020. By using regression analysis with the support of STATA software through examining the financial statements, which involves looking into crucial ratios including capital structure, profitability, firm size, accounts receivable management, and tangible assets investment, this study sheds light on whether these accounting indicators could help predict the construction and real estate companies growing potential in the future. Nevertheless, these ratios slightly contribute to the explanation of the change in revenue growth ratio, with a result of 1.6%, indicating that the value relevance of accounting information provides a modest and insignificant effect on investment decisions. This is understandable because the Vietnamese construction and real estate market still has many shortcomings in handling unexpected events, as well as the industry’s peculiarities related to major capital sources from bank loans. Based on this study, governmental authorities and business executives should plan appropriate risk management policies and measures to contribute to the sustainable development of construction and real estate companies.

Potential biological functions and future perspectives of sialylated milk oligosaccharides

Thuy Le Lam Nguyen,Dung Van Nguyen,Kyung-Sun Heo 대한약학회 2024 Archives of Pharmacal Research Vol.47 No.4

Sialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides(BMOs). First, the safety assessment of 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL) revealed low toxicity in variousanimal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients andbioactive components crucial for infant development, along with numerous associated health benefi ts for various diseases. This review explores the safety, biosynthesis, and potential biological eff ects of SLs, with a specifi c focus on their infl uenceacross various physiological systems, including the gastrointestinal system, immune disorders, rare genetic disorders (suchas GNE myopathy), cancers, neurological disorders, cardiovascular diseases, diverse cancers, and viral infections, thusindicating their therapeutic potential.

Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway

Thuy Le Lam Nguyen,Diem Thi Ngoc Huynh,Yujin Jin,Hyesu Jeon,Kyung-Sun Heo 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.2

Systemic or hepatic infl ammation is caused byintraperitoneal application of lipopolysaccharide (LPS). Inthis study, we investigated anti-infl ammatory and antioxidantproperties of combination of ginsenoside-Rg2 (G-Rg2) and-Rh1 (G-Rh1) on liver function under LPS challenging. Wefi rst confi rmed that G-Rg2 and -Rh1 at 100 μg/ml did notshow cytotoxicity in HepG2 cells. G-Rg2 and -Rh1 treatmentsignifi cantly inhibited activation of STAT3 and TAK1,and infl ammatory factors including iNOS, TNF-α, and IL-1βin peritoneal macrophages. In HepG2 cells, G-Rg2 and -Rh1treatment inhibited activation of STAT3 and TAK1/c-JunN-terminal kinase, and down-regulated nuclear translocationof NF-κB transcription factor. In addition, LPS-inducedmitochondrial dysfunction was restored by treatment withG-Rg2 and -Rh1. Interestingly, pretreatment with G-Rg2 and-Rh1 eff ectively inhibited mitochondrial damage-mediatedROS production induced by LPS stimulation, and alterationsof Nrf2 nuclear translocation and ARE promotor activitywere involved in G-Rg2 and -Rh1 eff ects on balancingROS levels. In liver tissues of LPS-treated mice, G-Rg2and -Rh1 treatment protected liver damages and increasedNrf2 expression while reducing CD45 expression. Takentogether, G-Rg2 and -Rh1 exerts a protective effect onliver function by increasing antioxidant through Nrf2 and anti-inflammatory activities through STAT3/TAK1 andNF-κB signaling pathways in liver cells and macrophages.

Inhibitory effects of 6′-sialyllactose on angiotensin II-induced proliferation, migration, and osteogenic switching in vascular smooth muscle cells

Thuy Le Lam Nguyen,Yujin Jin,Lila Kim,Kyung-Sun Heo 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.9

Excessive production and migration of vascularsmooth muscle cells (VSMCs) are associated with vascularremodeling that causes vascular diseases, such as restenosisand hypertension. Angiotensin II (Ang II) stimulation is akey factor in inducing abnormal VSMC function. This studyaimed to investigate the eff ects of 6′-sialyllactose (6′SL), ahuman milk oligosaccharide, on Ang II-stimulated cell proliferation,migration and osteogenic switching in rat aorticsmooth muscle cells (RASMCs) and human aortic smoothmuscle cells (HASMCs). Compared with the control group,Ang II increased cell proliferation by activating MAPKs,including ERK1/2/p90RSK/Akt/mTOR and JNK pathways. However, 6′SL reversed Ang II-stimulated cell proliferationand the ERK1/2/p90RSK/Akt/mTOR pathways in RASMCsand HASMCs. Moreover, 6′SL suppressed Ang II-stimulatedcell cycle progression from G0/G1 to S and G2/M phasesin RASMCs. Furthermore, 6′SL eff ectively inhibited cellmigration by downregulating NF-κB-mediated MMP2/9 andVCAM-1 expression levels. Interestingly, in RASMCs, 6′SLattenuated Ang II-induced osteogenic switching by reducingthe production of p90RSK-mediated c-fos and JNK-mediatedc-jun, leading to the downregulation of AP-1-mediatedosteopontin production. Taken together, our data suggestthat 6′SL inhibits Ang II-induced VSMC proliferation and migration by abolishing the ERK1/2/p90RSK-mediated Aktand NF-κB signaling pathways, respectively, and osteogenicswitching by suppressing p90RSK- and JNK-mediated AP-1activity.

Baseline susceptibility of Asian corn borer (Ostrinia furnacalis (Guenée)) populations in Vietnam to Cry1Ab insecticidal protein

Duc Khanh Le,Quang Khai Le,Thi Thuy Hang Tran,Duc Viet Nguyen,Thi Hang Dao,Thi Thuy Nguyen,Xuan Lam Truong,Quang Cuong Nguyen,Huy Phong Pham,Thi Thu Thuy Phan,Gajendra Babu Baktavachalam 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2

Susceptibility of Asian corn borer (ACB), Ostrinia furnacalis (Guenée) to Bacillus thuringiensis (Bt) Cry1Ab protein was studied between 2015 and 2016 with 11 ACB populations, collected from various geographical regions in Vietnam. A concentration range of Cry1Ab from 0.20 to 26.10 ng/cm 2 of diet was evaluated against F 1 ACB neonates using diet surface-overlay bioassays. Mortality data was recorded daily until seven days after infestation. Growth inhibition was recorded at the end of seven days. The median lethal concentration (LC 50 ) varied ≈3-fold among the different populations, ranging from 0.58 to 1.83 ng/cm 2 of diet with an overall mean of 0.86 ng/cm 2 of diet. Even the lowest concentration of 0.20 ng/cm 2 caused 73.53% growth inhibition. > 90% growth inhibition was achieved at 0.82 ng/cm 2 or higher concentrations. The results reflect natural variation in Bt susceptibility among ACB populations rather than variation caused by prior exposure to selection pressures. LC 99 value (17.26 ng/cm 2 ) was generated by pooling mortality data across different populations. The upper fiducial limit of LC 99 (24.38 ng/cm 2 ) could be a potential diagnostic dose for future resistance monitoring programs. The findings from this study suggest that ACB populations in Vietnam are highly susceptible to Cry1Ab protein. This is the first report of Cry1Ab susceptibility of different ACB populations in Vietnam and will serve as a baseline for future resistance monitoring work.

Effect of Ginsenoside Rg2 and Rh1 on Macrophage Inflammation-Mediated Liver Damage

Diem Thi Ngoc Huynh, Thuy Le Lam Nguyen, Kyung-Sun Heo 충남대학교 약학대학 의약품개발연구소 2021 藥學論文集 Vol.36 No.-

Ginsenosides have been reported to display diverse pharmacological effects, such as immune regulation and anticancer activity. In this study, we investigated the protective effect of a combination of ginsenoside Rg2 and Rh1 (G-Rg2 and -Rh1) on macrophages and liver function during septic shock induced by lip-opolysaccharide (LPS). In vitro experiments were performed using RAW264.7 cell line, and an in vivo model of inflammation was established using LPS-treated ICR mice. We assessed 3-(4,5-dimethylthiazole-2-yl)-2, 5-diphe- nyltetrazolium bromide assay, Western blot analysis, quantitative reverse transcription-polymerase chain reaction, and hematoxylin and eosin staining to evaluate the effect of G-Rg2 and -Rh1. We found that G-Rg2 and -Rh1 significantly inhibited LPS-caused nuclear factor kappa B (NF-κB) p65 activation in macrophages. Moreover, the combination treatment strongly abolished the mRNA expression of tumor necrosis factor-alpha and interleukin-1 beta induced by LPS in both RAW264.7 cells and peritoneal macrophages. Furthermore, signal transducer and activator of transcription 1 (STAT1) phosphorylation increased by LPS was dose-dependently decreased by G-Rg2 and -Rh1 treatment. Notably, the 20 mg/kg ginsenoside treatment significantly reduced LPS-induced acute liver inflammation levels in vivo, as indicated by the histological changes in liver tissue sections and the levels of aspartate transaminase, a biochemical marker for liver function from mouse serum. Taken together, our data demonstrated that G-Rg2 and -Rh1 exerted a key role in prevention of LPS-induced acute inflammation and liver damage by suppressing pro-inflammatory cytokine-mediated STAT1 activation through the inhibition of NF-κB acti- vation in macrophages.

Billroth-II Modified with Antiperistaltic Hinged Afferent Loop versus Roux-en-Y Reconstruction after Laparoscopic Distal Gastrectomy: A Propensity Score-Matched Analysis

Duy Long Vo,Quang Thong Dang,Quang Dat Tran,Viet Hai Nguyen,Le Minh Quoc Ho,Thuy Nguyen Doan,Anh Minh Tran,Vu Tuan Anh Nguyen,Lam Vuong Nguyen,Hoang Bac Nguyen 대한외과학회 2022 대한외과학회 학술대회 초록집 Vol.2022 No.11

Violation of Bans on Tobacco Advertising and Promotion at Points of Sale in Viet Nam: Trend from 2009 - 2015

Le, Thi Thanh Huong,Tran, Khanh Long,Phung, Xuan Son,Do, Phuc Huyen,Phan, Thuy Linh,Nguyen, Ngoc Bich,Nguyen, Xuan Lam,Le, Vu Anh,Tran, Thi Tuyet-Hanh Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1

Comprehensive bans on tobacco advertising and promotion were introduced through tobacco control legislation in Viet Nam, but it has been established that violations of the bans are very common. This study was conducted to explore the trend in violations of bans on tobacco advertising and promotion at points of sale in Viet Nam in the past six years and to explore any differences in the violation situations before and after the Law on Tobacco Control came into effect on 1st May 2013. Quantitative data were collected through observation of violations of the bans on tobacco advertising and promotion at points of sale in 10 provinces throughout Viet Nam in four survey rounds (2009, 2010, 2011, and 2015). Variation in violation prevalence over time was examined by chi-square test using a Bonferini method. Binary logistic regression was employed to identify the factors that may have influences on different types of violation. A level of significance of p<0.05 was used for all tests in this article. The most common form of violation was the display of more than one pack/one carton of a cigarette brand. Violation of bans on tobacco advertising increased while violations on promotion ban and on displaying tobacco decreased through time. Some factors associated with the tobacco advertising and promotion bans included surveyed years, types of points of sale, regions and areas where the points of sale were located. The enforcement of the bans did not improve even after the issuance and the enactment of the Law on Tobacco Control. This suggests that the monitoring and enforcement of bans on tobacco advertising and promotion at points of sale should be strengthened. Penalties should be strictly applied for violators as indicated in the current tobacco control legislation.

6′-Sialylactose abolished ipopolysaccharide-induced inflammation and hyper-permeability in endothelial cells

Dung Van Nguyen,Thuy Le Lam Nguyen,Yujin Jin,Lila Kim,Chang-Seon Myung,Kyung-Sun Heo 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.11

Disruption of the endothelial barrier functionand reduction in cell migration leads to endothelial dysfunction. One of the most abundant human milk oligosaccharides,6′-sialylactose (6′-SL), is reported to exert variousbiological functions related to infl ammatory responses. Inthis study, we evaluated the eff ects of 6′-SL on lipopolysaccharide(LPS)-induced infl ammation caused by endothelialbarrier damage. Our results showed that LPS at 500 ng/mLstrongly not only abolished cell migration but also hyperactivatedMAPK and NF-κB pathways. 6′-SL suppressedLPS-induced endothelial infl ammation via ERK1/2, p38,and JNK MAPK pathways. 6′-SL supported endothelialjunctions by upregulating PECAM-1 expression and mRNAlevels of tight junctions, such as ZO-1 and occludin, whichwere downregulated by LPS stimulation. It signifi cantlyinhibited the nuclear translocation of NF-κB, along withthe downregulation of infl ammatory cytokines, includingTNF-α, IL-1β, MCP-1, VCAM-1, and ICAM-1. Furthermore,6′-SL abolished NF-κB-mediated STAT3 in controllingendothelial migration and hyperpermeability viadownregulating STAT3 activation and nuclear translocation. Finally, LPS induced over-expression of VCAM-1 and ZO-1disassembly in both atheroprone and atheroprotective areasof mouse aorta, which were reversed by 6′-SL treatment. Altogether, our fi ndings suggest that 6′-SL is a potent therapeuticagent for modulating infl ammatory responses andendothelial hyperpermeability.

Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways

Yujin Jin,Hyesu Jeon,Thuy Le Lam Nguyen,Lila Kim,Kyung-Sun Heo 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.12

Acute lung injury (ALI) is the leading cause of respiratory diseases induced by uncontrolled inflammation and cell death. Lipopolysaccharide (LPS) is a major trigger of ALI in the progression through macrophage differentiation and the accelerated release of pro-inflammatory cytokines. The present study aimed to investigate the protective effects of human milk oligosaccharides, specifically 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL), on LPS-induced ALI and elucidate their underlying signaling pathways. The inhibitory effects of 3′-SL and 6′-SL on inflammation were evaluated using LPS-treated RAW 264.7 macrophages. To establish the ALI model, mice were treated with 10 mg/kg LPS for 24 h. Histological changes in the lung tissues were assessed using hematoxylin and eosin staining and immunofluorescence. LPS causes thickening of the alveolar wall infiltration of immune cells in lung tissues and increased serum levels of TNF-α, IL-1β, and GM-CSF. However, these effects were significantly alleviated by 100 mg/kg of 3′-SL and 6′-SL. Consistent with the inhibitory effects of 3′-SL and 6′-SL on LPS-induced pro-inflammatory cytokine secretion in serum, 3′-SL and 6′-SL suppressed mRNA expression of TNF-α, IL-1β, MCP-1, iNOS, and COX2 in LPS-induced RAW 264.7 cells. Mechanistically, 3′-SL and 6′-SL abolished LPS-mediated phosphorylation of NF-κB and STAT1. Interestingly, fludarabine treatment, a STAT1 inhibitor, did not affect LPS-mediated NF-κB phosphorylation. In summary, 3′-SL and 6′-SL protect LPS-induced macrophage activation and ALI through the STAT1 and NF-κB signaling pathways.