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Michael O. J. Thomas,Ye Yoon Hong 대한수학교육학회 2005 수학교육학연구 Vol.15 No.2
Computer algebra system (CAS) calculators are becoming increasingly common in schools and universities. While they offer quite sophisticated mathematical capability to teachers and students, it is not clear at present how they may best be employed. In particular their integration into students' learning and problem-solving remains an issue. In this paper we address this issue through the lens of a study that considered the introduction of the TI-89 CAS calculator to students about to enter university. We describe a number of different aspects of the partnership they formed with the calculator as they began the process of instrumentation of the CAS in their learning. 컴퓨터 대수 체계(CAS) 계산기는 점차 학교와 대학에서 보편화되어가고 있다. 이 계산기는 교사와 학생들에게 꽤 정교한 수학적 기능을 제공하지만, 현재로서는 어떻게 잘 활용될 수 있는지에 대해서 명확하지 않다. 특히 학생들의 학습과 문제 해결의 통합은 문제로 남아있다. 본 논문에서 우리는 TI-89 CAS 계산기를 대학에 입학하려는 학생들에게 도입하는 연구에서 이러한 문제를 제기하고 학생들이 그들의 학습에서 CAS 계산기를 조작하면서 형성하는 협력 관계의 여러 측면을 기술하였다.
Hamacher, Michael,Apweiler, Rolf,Arnold, Georg,Becker, Albert,Blü,ggel, Martin,Carrette, Odile,Colvis, Christine,Dunn, Michael J.,Frö,hlich, Thomas,Fountoulakis, Michael,van Hall, André WILEY-VCH Verlag 2006 Proteomics Vol.6 No.18
<P>The Human Proteome Organisation (HUPO) initiated several projects focusing on the proteome analysis of distinct human organs. The Brain Proteome Project (BPP) is the initiative dedicated to the brain, its development and correlated diseases. Two pilot studies have been performed aiming at the comparison of techniques, laboratories and approaches. With the help of the results gained, objective data submission, storage and reprocessing workflow have been established. The biological relevance of the data will be drawn from the inter-laboratory comparisons as well as from the re-calculation of all data sets submitted by the different groups. In the following, results of the single groups as well as the centralised reprocessing effort will be summarised and compared, showing the added value of this concerted work.</P>
Thomas R Williamson,Patrick G Robinson,Iain R Murray,Andrew D Murray,Julie M McBirnie,C Michael Robinson,Deborah J MacDonald,Nicholas D Clement 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.2
Background: Golf is a popular sport involving overhead activity and engagement of the rotator cuff (RC). This study aimed to determine to what level golfers were able to return to golf following RC repair, the barriers to them returning to golf and factors associated with their failure to return to golf. Methods: Patients preoperatively identifying as golfers undergoing RC repair at the study centre from 2012 to 2020 were retrospectively followed up with to assess their golf-playing status, performance and frequency of play and functional and quality of life (QoL) outcomes. Results: Forty-seven golfers (40 men [85.1%] and 7 women [14.9%]) with a mean age of 56.8 years met the inclusion criteria, and 80.1% were followed up with at a mean of 27.1 months postoperatively. Twenty-nine patients (76.3%) had returned to golf with a mean handicap change of +1.0 (P=0.291). Golf frequency decreased from a mean of 1.8 rounds per week preinjury to 1.5 rounds per week postoperatively (P=0.052). The EuroQol 5-dimension 5-level (EQ-5D-5L) index and visual analog scale (EQ-VAS) score were significantly greater in those returning to golf (P=0.024 and P=0.002), although functional outcome measures were not significantly different. The primary barriers to return were ipsilateral shoulder dysfunction (78%) and loss of the habit of play (22%). Conclusions: Golfers were likely (76%) to return to golf following RC repair, including mostly to their premorbid performance level with little residual symptomatology. Return to golf was associated with a greater QoL. Persistent subjective shoulder dysfunction (78%) was the most common barrier to returning to golf.
Michael J. Domingue,Thomas C. Baker 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1
The spotted lanternfly, Lycorma delicatula, (Hemiptera, Fulgoridae) is an invasive pest to Korea and the United States, originating from China or Southeast Asia. Immature L. delicatula feed on a wide range of plants, but the adults are more host-selective, often preferring the tree of heaven, Ailanthus altissima. We performed field studies to evaluate adult movement in relation to A. altissima after disturbance. The Ailanthus trees were in a mixed suburban forested situated at the southern border of an open grassy field. Female adult lanternflies were manually disturbed from feeding on the trunks of large A. altissima trees. In the first experiment, insects were disturbed directly from the tree using a ballpoint pen to simulate a predatory attack. These insects usually flew initially southward away from the tree line toward a sunlit field, but turned northward back toward the tree line. In the second experiment, to simulate an initially successful predatory attack, they were manually taken from trees, and allowed to escape. The females immediately opened their wings in an apparent aposematic display. They then either immediately flew toward the sunlit open field, or remained with their wings splayed open for a prolonged period.
IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes
Michael Bonelli,Karolina Dalwigk,Alexander Platzer,Isabel Olmos Calvo,Silvia Hayer,Birgit Niederreiter,Johannes Holinka,Florian Sevelda,Thomas Pap,Günter Steiner,Giulio Superti-Furga,Josef S. Smolen,H 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Rheumatoid arthritis (RA) is an autoimmune disease characterized by persistent synovial inflammation. The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory mediators. Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis mouse model. Transcriptomic analyses of IRF1-deficient, TNF-stimulated FLSs define the interferon (IFN) pathway as a major target of IRF1. IRF1 expression is associated with the expression of IFNβ, which leads to the activation of the JAK-STAT pathway. Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib) baricitinib or tofacitinib reduces the expression of IFN-regulated genes (IRGs) in TNF-activated FLSs. Therefore, we conclude that TNF induces a distinct inflammatory cascade, in which IRGs are key elements, in FLSs. The IFN-signature might be a promising biomarker for the efficient and personalized use of new treatment strategies for RA, such as JAKinibs.