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Linh Thi Thao Nguyen,송연우,Thao Anh Tran,김기석,김소미 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is aspecial form of apoptosis in which cells loose contact with othercells or the extracellular matrix. In the present study, we havefound that the breast cancer stem cell line MCF-7-SC, isolatedfrom MCF-7 breast cancer cells, shows characteristics of anoikisresistance. Treatment of supercritical CO2 extract from Citrushassaku Hort ex Tanaka, locally known as Phalsak, reduced theexpression of ATP-binding cassette sub-family G member 2mRNA and induced apoptosis in MCF-7-SCs, as evidenced by anincrease of apoptotic body formation, increased cell population inthe sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolyticactivation of caspase-9 and caspase-3, and the degradation ofpoly(ADP-ribose) polymerase (PARP) protein. The effects ofsupercritical CO2 extract from Phalsak on anoikis-resistant breastcancer stem cells suggest the use of this extract as a potentialtherapeutic agent for breast cancer stem cell treatment.
Nguyen, Linh Thi Thao,Song, Yeon Woo,Tran, Thao Anh,Kim, Ki-Seok,Cho, Somi Kim The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is a special form of apoptosis in which cells loose contact with other cells or the extracellular matrix. In the present study, we have found that the breast cancer stem cell line MCF-7-SC, isolated from MCF-7 breast cancer cells, shows characteristics of anoikis resistance. Treatment of supercritical $CO_2$ extract from Citrus hassaku Hort ex Tanaka, locally known as Phalsak, reduced the expression of ATP-binding cassette sub-family G member 2 mRNA and induced apoptosis in MCF-7-SCs, as evidenced by an increase of apoptotic body formation, increased cell population in the sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolytic activation of caspase-9 and caspase-3, and the degradation of poly(ADP-ribose) polymerase (PARP) protein. The effects of supercritical $CO_2$ extract from Phalsak on anoikis-resistant breast cancer stem cells suggest the use of this extract as a potential therapeutic agent for breast cancer stem cell treatment.
Thao, L. Q.,Byeon, H. J.,Lee, C.,Lee, S.,Lee, E. S.,Choi, Y. W.,Choi, H. G.,Park, E. S.,Lee, K. C.,Youn, Y. S. Springer Science + Business Media 2016 Pharmaceutical research Vol.33 No.3
<P>We developed a new nanoparticle formulation comprised of human serum albumin (HSA) for co-delivery of doxorubicin (Dox) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with the goal of apoptotic synergy in the treatment of colon cancer. TRAIL (0.2, 0.4, 1.0%)- and Dox-loaded HSA nanoparticles (TRAIL/Dox HSA NPs) were prepared by using the nab(TM) technology. Morphological and physicochemical characterizations were investigated by dynamic light scattering and transmission electron microscopy. Synergistic cytotoxicity, apoptotic activity, and potential penetration into mass tumor were determined in HCT116 cell-based systems. Furthermore, antitumor efficacy and tumor targeting were also investigated. TRAIL/Dox HSA NPs were uniformly spherical with sizes of 60 similar to 120 nm. The encapsulation efficacy of Dox and TRAIL was 68.9-77.2% and 80.4-86.0%, respectively. TRAIL 1.0%/Dox HSA NPs displayed the best inhibition of HCT116 colon cancer cells; inhibition was 6 times higher than achieved with Dox HSA NPs. The TRAIL 1.0%/Dox HSA NPs formulation was studied further. Flow cytometry analysis and TUNEL assay revealed that TRAIL 1.0%/Dox HSA NPs had markedly greater apoptotic activity than Dox HSA NPs. In HCT116 tumor-bearing BALB/c nu/nu mice, TRAIL 1.0%/Dox HSA NPs had significantly higher antitumor efficacy than Dox HSA NPs (tumor volume; 933.4 mm(3) vs. 3183.7 mm(3), respectively). TRAIL 1.0%/Dox HSA NPs penetrated deeply into tumor masses in a HCT116 spheroid model and localized in tumor sites after tail vein injection. Data indicate that TRAIL 1.0%/Dox HSA NPs offer advantages of co-delivery of Dox and TRAIL in tumors, with potential synergistic apoptosis-based anticancer therapy.</P>
Thao Tram Le Nguyen,Xuan Loc Vu Doan,Vy Thuc Nguyen 아시아심장혈관영상의학회 2020 Cardiovascular Imaging Asia Vol.4 No.4
Anomalous left coronary artery from the pulmonary artery (ALCAPA) syndrome is a rare congenital coronary artery anomaly. Clinical presentation can range from asymptomatic conditions to sudden death with exertion. The majority of cases is diagnosed in childhood and dies within the first year, however medical literature has confirmed several cases in adults. We report a case of a 49-year-old woman hospitalized for vague chest pain. Echocardiography found collateral circulation on the anterior wall, and ALCAPA syndrome was diagnosed on multislice CT.
Thao Truong-Dinh Tran,이범진,Phuong Ha-Lien Tran,박준범 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7
For the quality evaluation of raw materials, the influence of various types of solvents on the polymorphic crystallization behaviors and dissolution rates of two sources of valsartan (VAL) from China and India was investigated. Samples were prepared by recrystallization from water or organic solvents, such as acetonitrile, acetone and ethanol, using methods with and without heating. Recrystallization behaviors were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Scanning electron microscopy (SEM) was also used to observe the morphology of samples. The dissolution rate of recrystallized samples in water was evaluated and compared to the original VAL sample. There were significant differences in morphology, crystal structure and dissolution rate among the samples recrystallized using organic solvents. VAL was transformed into another polymorphic form by the solvents and recrystallization conditions. These physical properties of VAL also differed between the two sources of VAL. Thus, the physicochemical differences of raw materials should be carefully considered in early dosage formulation approaches.
An Evaluation Approach for Prediction of Process Parameters with Genetic Algorithm
Thao, D.T.,Kim, Il Soo Trans Tech Publications, Ltd. 2008 Materials science forum Vol.580 No.-
<P>Gas Metal Arc (GMA) welding process has widely been employed due to the wide range of applications, cheap consumables and easy handling. A suitable mathematical model to achieve a high level of welding performance and quality should be required to study the characteristics for the effects of process parameters on the bead geometry in the GMA welding process. The objective of this paper is to present development of three empirical models (linear, curvilinear and intelligent model) based on full factorial design with two replications to estimate process parameters on top-bead width in robotic GMA welding process. Regression analysis was employed for optimization of the coefficients of linear and curvilinear models, but Genetic Algorithm (GA) was utilized to estimate the coefficients of intelligent model. ANOVA analysis using experimental data were carried out representation of main and interaction effects between process parameters on top-bead width. Resulting solutions and graphical representation showed that the developed intelligent model can be used for prediction on top-bead width in robotic GMA welding process</P>
A Survey on Face-based Cryptographic Key Generation
Thao Dang,Deokjai Choi (사)한국스마트미디어학회 2020 스마트미디어저널 Vol.9 No.2
Derivation cryptographic keys from human biometrics opens a new promising research area when it can be used efficiently for not only verification or recognition tasks, but also symmetric-key based applications. Among existing biometric traits, face is considered as the most popular biometrics since facial features are informative and discriminative. In this paper, we present a comprehensive survey of Face-based key generation (FKGS). First, we summarize the trend of FKGS researches and sum up the methods which play important roles in the proposed key generation systems. Then we present the evaluation and the general performance analysis; from that, we give a discussion about the advantages and disadvantages of surveyed studies to clarify the fundamental requirements and the main challenges when implementing FKGS in practice. Finally, an outlook on future prospects is given
Thao Thi Phuong Nguyen,Hiroshi Amano 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Temperature is an important inorganic factor which affects on every aspect in life of phytoseiid mites in general including N. californicus in this study. Cumulative and short-term effects of temperature through different life stages (immature, mating and oviposition periods) on mating duration and total fecundity of N. californicus were investigated at temperatures of 18, 25, 30 and 350C with a photoperiod of 16L:8D. Throughout experiments, females mated once and egg production was observed until they stop oviposition.