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Thakker, Shalin,Biradar, S.M.,Habbu, P.V.,Mahadevan, K.M.,Thippeswamy, B.S.,Veerapur, V.P. Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.4
The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.
Shalin Thakker,S M Biradar,PV Habbu,KM Mahadevan,BS Thippeswamy,VP Veerapur 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.4
The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.
Ajit Thakker,Hammad Bin Khaleeq,Manabu Takao,Toshiaki Setoguchi 대한기계학회 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.11
The objective of this paper is to present the performance comparison of the impulse turbines for different diameters. In the study, the investigation has been performed experimentally by model testing for some diameters, especially 0.3 m and 0.6 m. The experiment was performed for Reynolds number range of 0.17 X 10^5-1.09 X 10^5 and for different values of hub-to-tip ratio ν ranging from 0.6 to 0.85. As a result, it was found that the critical Reynolds number is to be around 0.5 X 10%5 for ν=0.6 and 0.4 X 10^5 for ν=0.7. For the hub-to-tip ratio, the optimum value is 0.7 when the turbine is operated at lower Reynolds number. However, its value seems to be 0.6 at higher Reynolds number in the tested range.