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Triptolide Inhibits Proliferation and Induces Apoptosis of Human Melanoma A375 Cells
Tao, Yue,Zhang, Meng-Li,Ma, Peng-Cheng,Sun, Jian-Fang,Zhou, Wu-Qing,Cao, Yu-Ping,Li, Ling-Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Triptolide, a diterpenoid obtained from Tripteryglum wilfordii Hook.f, has attracted interest for its antitumor activities against human tumor cell lines in recent years. This report focuses on anti-proliferative and pro-apoptotic activities in human melanoma A375 cells assessed by CCK8 assay, Hoechst 33258 staining and flow cytometry. In addition, triptolide-induced arrest in the S phase was also observed. Caspase assays showed the apoptosis induced by triptolide was caspase-dependent and probably through intrinsic apoptotic pathways. Furthermore, expression of NF-${\kappa}B$ (p65) and its downstream factors such as Bcl-2, Bcl-$X_L$ was down-regulated. Taken together, the data indicate that triptolide inhibits A375 cells proliferation and induces apoptosis by a caspase-dependent pathway and through a NF-${\kappa}B$-mediated mechanism.
The New Strategy of Object-Based Directional Query
Run-tao liu,Yan-ming Wang,Zhen-guo Zhao,Guang -Yue Tian 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6
To increase directional query efficiency, based on the study of existing algorithms of directional query, new pruning rules for directional query were given, combined with the new index structure MB-tree. The rules exclude the MBRs outside the query area and output all leaf nodes in the MBRs inside the query area. Based on the orders defined in MB-tree, a new algorithm of directional query is given combining with MB-tree by using recursive method, and the new algorithm can reduce I/O cost effectively. Experiment showed that the new directional query algorithm reduces the number of visited nodes, decreases I/O cost, and improves the efficiency of directional query.
Yue Lin,Yuanyuan Zhang,Qiongtao Song,Tao Song,Xue Han,Ying Zhang,Xuan Zhang,Xi Chu,Fenghua Zhang,Li Chu,Jianping Zhang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10
To explore the cardiovascular protective effectsof Magnesium isoglycyrrhizinate (MI), especially theunderlying cellular mechanisms related to L-type calciumchannels and myocardial contractility, and to examine theeffects of MI on hERG K? current expressed in HEK293cells. We used the whole-cell patch clamp technique,video-based edge detection and dual excitation fluorescencephotomultiplier systems to explore the effect of MIon L-type Ca2? currents (ICa-L) and cell contraction in ratcardiomyocytes. We also examined the rapidly activatingdelayed rectifier potassium current (IKr) expressed inHEK293 cells using a perforated patch clamp. MI inhibitedICa-L in a dose-dependent manner, with a half-maximalinhibitory concentration (IC50) of 0.22 mg/ml, and themaximal inhibitory effect was 61.10 ± 0.59%. MI at aconcentration of 0.3 mg/ml reduced cell shortening by24.12 ± 3.97% and the peak value of the Ca2? transient by36.54 ± 4.96%. MI had no significant influence on hERGK? channels expressed in HEK293 cells at all testpotentials. MI exerts protective effects on the heart via theinhibition of ICa-L and cell shortening in rat cardiomyocytes. However, MI had no significant influence on IKr;thus, MI may exert cardioprotective effects without causingdrug-induced long QT syndrome.
Tao Zhang,Bin Gu,Fengxian Qiu,Xiaoming Peng,Xuejie Yue,Dongya Yang 한국섬유공학회 2018 Fibers and polymers Vol.19 No.10
Polyurethane (PU) hybrid materials have attracted a great deal of attention as oil-absorbents in oil/water separation because they combine the surface properties of nanomaterials and the excellent absorption properties of PU. Herein, we report a facile two-step process to synthesize the oil-absorbing hybrid materials by integrating carbon nanotubes (CNTs) into porous PU foam architectures. First, the multi-walled carbon nanotubes (MWCNTs) were modified by oxidation in binary H2SO4-HNO3 mixed acid, followed by grafting the silane coupling agent (KH 570) on the on surfaces of MWCNTs. Then, the MWCNTs/PU hybrid materials were synthesized using isocyanate and polyether polyol as monomers for polymerization and surface modified MWCNTs as inorganic components. The physical and chemical properties of hybrid materials were validated by XRD, TEM, SEM, N2 sorption and contact angle analysis. The surface grafted MWCNTs possess superhydrophobic properties with the maximum water contact angle of 153 o. The SEM results indicate that the WCNTs/PU hybrid materials consisted of spherical structures with microscale holes, which can separate oils from oil/water mixtures with high absorption properties and high selectivity. Effects of the various MWCNTs contents on the oil absorption behavior of the WCNTs/PU hybrid materials were investigated. The results show that the modified MWCNTs significantly improves the oil absorption properties with the optimal MWCNTs content of 3 %. By combining the structural features of WCNTs and PU foams, the hybrid materials not only exhibit excellent absorption properties for various types of oils and organic solvents, but also show excellent oil recoverability and absorbent regenerability. The as-synthesized WCNTs/PU hybrid have significant potential as oil absorbents for efficient separation of oils and organic solvents from water.
Tao Zhang,Xinbin Nie,Xuejie Yue,Dongya Yang,Yuting Dai,Fengxian Qiu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.3
Hierarchically structured BiOCl/LDHs composites with well-developed porosity and high surface area have been prepared by an in situ growth of BiOCl on the surfaces LDHs fibers, and their adsorption capacities and photocatalytic activities are investigated by using methylene blue (MB) as model pollutants. The results indicate that the BiOCl/LDHs composites possess high surface area up to 126.2 m2/g. The as-prepared BiOCl/LDHs composites exhibited higher adsorptive ability and improved photocatalytic activity compared to bare BiOCl particles and LDHs fibers based on the removal of MB in aqueous solution, showing that BiOCl/LDHs composites can be used as efficient environmentally friendly materials for dye wastewater treatment.
Yue-Hua Guo,Fu-Rong Li,Shi-Yun Bao,Tao Han,Jun-Jian Cao,Han-Xin Zhou 한국물리학회 2007 Current Applied Physics Vol.7 No.s1
The present work is intended to set up the optimal carboplatin-Fe@C-loaded chitosan nanoparticles method and to compare andassess carboplatin-Fe@C-loaded with carboplatin-Fe-loaded chitosan nanoparticles. Both kinds of nanoparticles were prepared by areverse microemulsion method. The carboplatin-Fe@C-loaded chitosan nanoparticles consisted of Fe@C nanopowder with the adsorbeddrug as the magnetic core, chitosan as the matrix and carboplatin as the model drug. The core of the carboplatin-Fe-loaded chitosannanoparticles was pure iron nanopowder, which was unable to adsorb a drug. The characteristics of both kinds of nanoparticles weredetermined and compared. The results showed that both kinds of nanoparticles were spherical in shape with an average size of210 nm ± 26 nm (size range 150300 nm) and a good magnetic responsivity. The drug content of the nanoparticles wasrespectively. The cumulative release percentages of carboplatin-Fe@C-loaded chitosan nanoparticles in vitro in 1d, 2d, 3d, 4d were60%, 74%, 84%, and 92%, respectively, and those of carboplatin-Fe-loaded chitosan nanoparticles in 1d, 2d were 81% and 91%. Thus,the carboplatin-Fe@C-loaded chitosan nanoparticles with dual physical drug-loaded mechanisms (physical encapsulation and adsorp-tion of active carbon) possessed a higher drug content and showed more sustained releasing. The cooperation of multiple mechanismswas a promising feature to improve the properties of nanoparticles.
Optical Planar Waveguides Fabricated by Using Carbon Ion Implantation in Terbium Gallium Garnet
Yue Wang,Xiao-Liang Shen,Rui-Lin Zheng,Peng Lv,Chun-Xiao Liu,Hai-Tao Guo 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.7
Optical planar waveguides in terbium-gallium-garnet (TGG) crystals are promising photonic devices, particularly for optical isolators and rotators. In this work, to the best of our knowledge, we report on the fabrication and the characterization of TGG waveguides for the first time. The fabrication procedure involved carbon ion implantation at an energy of 6.0 MeV and a fluence of 5.0×1014 ions/cm2. The effective refractive indices of the propagation modes in the carbonimplanted waveguide were measured by using the prism-coupling technique. The profile of the refractive index and the distribution of the near-field intensity were calculated by using the reflectivity calculation method and the finite-difference beam propagation method, respectively. The carbon-implanted TGG waveguide is considered to be a candidate for a magneto-optical photonic device.
Investigation of Eco-friendly Dyeing of Para-aramid Using Supercritical CO2
Yue Zhang,Huanda Zheng,Laijiu Zheng,Tao Cai,Fuer Zheng 한국섬유공학회 2022 Fibers and polymers Vol.23 No.8
In order to solve the problems of dyeing difficulty and serious pollution of traditional water-based dyeing of paraaramid,supercritical CO2 fluid was employed as a dyeing solvent to dye para-aramid yarn (temperatures 80-120 ℃, pressures16-24 MPa, dyeing time 15-90 min, and dye concentration 1 %-7 % o.m.f.). The K/S values reached 2.07 and 1.91 at 120 ℃,24 MPa, 60 min, 5 % o.m.f., and a CO2 flow of 20 g/min with C. I. Disperse Red 54 and C. I. Disperse Blue 79, respectively. The results proved that para-aramid yarn could be dyed in supercritical CO2 fluid. Moreover, the thermal and mechanicalproperties of dyed para-aramid yarns in supercritical CO2 showed a slightly increasing trend. The washing, rubbing, and thelight color fastness of the dyed samples were rated above 4-5, and the color fastness durability of the dyed para-aramid wasalso presented good.
Yue Zhang,Ting-Ting Li,Bing-Chiuan Shiu,Fei Sun,Hai-Tao Ren,Xue-Fei Zhang,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1
Medical product contamination is a serious threat to patients’ health. However, designing medical covers thatensure Janus performance and outstanding abrasion resistance, mechanical performances has remained a great challenge. Inthis study, a novel Janus nonwoven fabric nonwoven fabric consists of a hydrophilic inner layer of polylactic acid (PLA)/lowmeltingpolylactic acid (LPLA) and a coated outer layer of hydrophobic thermoplastic polyurethane (TPU) is successfullyfabricated. The subsequent PLA/LPLA-TPU textiles exhibits excellent protective performance of inner absorption. Moreover, the coating improves tensile strength and increases abrasion resistance. A mechanism of mechanical failure isfurther studied. This kind of nonwoven fabric is suggested to be a promising candidate for medical covers and health supplies.