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Tanasa, Constantin,Bosioc, Alin,Susan-Resiga, Romeo,Muntean, Sebastian Korean Society for Fluid machinery 2011 International journal of fluid machinery and syste Vol.4 No.1
Our previous experimental and numerical investigations of decelerated swirling flows in conical diffusers have demonstrated that water jet injection along the symmetry axis mitigates the pressure fluctuations associated with the precessing vortex rope. However, for swirling flows similar to Francis turbines operated at partial discharge, the jet becomes effective when the jet discharge is larger than 10% from the turbine discharge, leading to large volumetric losses when the jet is supplied from upstream the runner. As a result, we introduce the flow-feedback approach for supplying the jet by using a fraction of the discharge collected downstream the conical diffuser. Experimental investigations on mitigating the pressure fluctuations generated by the precessing vortex rope and investigations of pressure recovery coefficient on the cone wall with and without flow-feedback method are presented.
Lin, C.,Yang, L.,Tanasa, B.,Hutt, K.,Ju, B.g.,Ohgi, K.A.,Zhang, J.,Rose, D.W.,Fu, X.D.,Glass, C.K.,Rosenfeld, M.G. Cell Press ; MIT Press 2009 Cell Vol.139 No.6
Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid tumors, but the underlying mechanism remains elusive. By establishing a cellular model that mimics the relative frequency of authentic translocation events without proliferation selection, we report mechanisms of nuclear receptor-dependent tumor translocations. Intronic binding of liganded androgen receptor (AR) first juxtaposes translocation loci by triggering intra- and interchromosomal interactions. AR then promotes site-specific DNA double-stranded breaks (DSBs) at translocation loci by recruiting two types of enzymatic activities induced by genotoxic stress and liganded AR, including activation-induced cytidine deaminase and the LINE-1 repeat-encoded ORF2 endonuclease. These enzymes synergistically generate site-selective DSBs at juxtaposed translocation loci that are ligated by nonhomologous end joining pathway for specific translocations. Our data suggest that the confluence of two parallel pathways initiated by liganded nuclear receptor and genotoxic stress underlies nonrandom tumor translocations, which may function in many types of tumors and pathological processes.