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        Honey Bee Based Load Balancing in Cloud Computing

        ( Melissa Teo ),( Tan Jui Horng ),( Zetty Akhtar bte Md Eizak ),( Esther Lim ),( Eunice Ho ),( Jamila Binti Mustaffa ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.12

        The technology of cloud computing is growing very quickly, thus it is required to manage the process of resource allocation. In this paper, load balancing algorithm based on honey bee behavior (LBA_HB) is proposed. Its main goal is distribute workload of multiple network links in the way that avoid underutilization and over utilization of the resources. This can be achieved by allocating the incoming task to a virtual machine (VM) which meets two conditions; number of tasks currently processing by this VM is less than number of tasks currently processing by other VMs and the deviation of this VM processing time from average processing time of all VMs is less than a threshold value. The proposed algorithm is compared with different scheduling algorithms; honey bee, ant colony, modified throttled and round robin algorithms. The results of experiments show the efficiency of the proposed algorithm in terms of execution time, response time, makespan, standard deviation of load, and degree of imbalance.

      • KCI등재후보

        IDENTIFYING SUPPORT NEEDS OF ELDERLY CAREGIVERS OF CLIENTS WITH INTELLECTUAL DISABILITIES IN SUPPORTED EMPLOYMENT SERVICES IN SINGAPORE

        Melissa Teo,Tan Jui Horng,Zetty Akhtar bte Md Eizak,Esther Lim,Eunice Ho,Jamila Binti Mustaffa 대구대학교 한국특수교육문제연구소 2017 Asia-Pacific Journal of Intellectual Disabilities Vol.4 No.2

        The expanding population of elderly parents who continue to care for their child with intellectual disabilities well into old age is a growing concern (Hubert & Hollins, 2000). The research aims to assess the needs of elderly parents as caregivers and the perceived needs of their child with intellectual disabilities. Semi structured interviews were undertaken with 10 caregivers aged 65 years and above. The interviews focused on identifying elderly caregivers’ needs and the perceived needs of their child. Care plans were developed, in which caregivers’ and clients’ needs were prioritized. Elderly caregivers expressed support needs in several areas; social interaction and emotional support were common themes. When discussing their child’s care plan, the need for their child to acquire Activities of Daily Living Skills and functional academics were some pertinent concerns. Other significant needs in their child’s care plan include transitional planning, residential support and early intervention of medical issues. Identifying the support needs of elderly caregivers, and developing appropriate care plans are important to provide the necessary support as they age. Emphasis was also given in training clients to be independent, with the goal that they can be a support to their elderly parents.

      • SCIESCOPUSKCI등재

        Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen species-dependent inactivation of the PI3K/AKT pathway

        Kok-Tong Tan,Yu-Hung Shih,Jiny Yin Gong,Xiang Zhang,Chiung-Yao Huang,Jui-Hsin Su,Jyh-Horng Sheu,Chi-Chen Lin The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4

        Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species Cladiella australis, has shown cytotoxic effects against cancer cells. However, it is unknown whether DA has antitumor effects on nasopharyngeal carcinoma (NPC). In this study, we determined the antitumor effects of DA and investigated its mechanism of action on human NPC cells. The MTT assay was used to determine the cytotoxic effect of DA. Subsequently, apoptosis and reactive oxygen species (ROS) analyses were performed by using flow cytometry. Apoptotic and PI3K/AKT pathway-related protein expression was determined using Western blotting. We found that DA significantly reduced the viability of NPC-39 cells and determined that apoptosis was involved in DA-induced cell death. The activity of caspase-9, caspase-8, caspase-3, and PARP induced by DA suggested caspase-mediated apoptosis in DA-treated NPC-39 cells. Apoptosis-associated proteins (DR4, DR5, FAS) in extrinsic pathways were also elevated by DA. The enhanced expression of proapoptotic Bax and decreased expression of antiapoptotic BCL-2 suggested that DA mediated mitochondrial apoptosis. DA reduced the expression of pPI3K and p-AKT in NPC-39 cells. DA also reduced apoptosis after introducing an active AKT cDNA, indicating that DA could block the PI3K/AKT pathway from being activated. DA increased intracellular ROS, but N-acetylcysteine (NAC), a ROS scavenger, reduced DA-induced cytotoxicity. NAC also reversed the chances in pPI3K/AKT expression and reduced DA-induced apoptosis. These findings suggest that ROS-mediates DA-induced apoptosis and PI3K/AKT signaling inactivation in human NPC cells.

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