http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hepatoprotection by Semisulcospira libertina against Acetaminophen - Induced Hepatic Injury in Mice
Tae Won Jeon,Young Sun Lee,Hyo Jung Kim 한국식품영양과학회 2003 Preventive Nutrition and Food Science Vol.8 No.3
Recently, we reported (J Korean Soc Food Sci Nutr, 31(3): 516-520, 2002) that Semisulcospira libertina (Marsh Snail) pretreatment has a hepatoprotective effect on CCl4-induced liver damage in rats. The purpose of this study was to investigate the possible mechanisms of hepatoprotection by S. libertina (SL) on liver injury induced by acetaminophen (AA). Male ICR mice were pretreated with dehydrated powder of SL once daily for three consecutive days, given a single toxic dose of AA (450 mg/kg) and liver function determined 24 h later. Liver damage was assessed by quantifying serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and sorbitol dehydrogenase (SDH) activities, and by measuring hepatic lipid peroxidation. To confirm possible mechanism(s), the content of hepatic glutathione (GSH) and gene expression of tumor necrosis factor α (TNFα) mRNA by reverse transcription-polymerase chain reaction (RTPCR) were also measured. Pretreatment with SL dramatically lowered AA-elevated ALT, AST and SDH activities. SL pretreatment decreased AA-produced lipid peroxidation by 11% and restored the AA-depleted hepatic GSH by 27%. Furthermore, SL markedly suppressed the expression of TNFα mRNA induced by AA. Our findings revealed that the possible hepatoprotective mechanisms of SL could be attributed, at least in part, to the glutathione-mediated detoxification as well as the regulation of TNFα mRNA expression.
Hepatotoxic Effects of 1-Furan-2-yl-3-pyridin-2-yl-propenone, a New Anti-Inflammatory Agent, in Mice
( Tae Won Jeon ),( Chun Hwa Kim ),( Sang Kyu Lee ),( Sil Shin ),( Jae Ho Choi ),( Won Ku Kang ),( Sang Kyun Kim ),( Mi Jeong Kang ),( Eung Seok Lee ),( Tae Cheon Jeong ) 한국응용약물학회 2009 Biomolecules & Therapeutics(구 응용약물학회지) Vol.17 No.3
Immunotoxicological Investigation of 1-furan-2-yl-3-pyridin-2-yl-propenone in Female BALB/c Mice
( Tae Won Jeon ),( Chun Hwa Kim ),( Sang Kyu Lee ),( Gyu Sub Ko ),( Jin Woo Yoo ),( Hyun Woo Ha ),( Won Ku Kang ),( Hye Gwang Jeong ),( Mi Jeong Kang ),( Eung Seok Lee ),( Tae Cheon Jeong ) 한국응용약물학회 2009 Biomolecules & Therapeutics(구 응용약물학회지) Vol.17 No.4
Effects of Polycyclic Aromatic Hydrocarbons on Liver and Lung Cytochrome P450s in Mice
JiYoungKim,SangKyuLee,ChunHwaKim,TaeWonJeon,문창규,Hye-SookLee,SunDongYoo,EungSeokLee,TaeCheonJeong 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.5
Certain polycyclic aromatic hydrocarbons (PAHs) have been reported to induce cytochrome P450 (CYP) 1A1 and 1A2. In the present study, the effects of six well-known PAHs, such as benzo[a]pyrene, benz[a]anthracene, dibenz[a,h]anthracene, chrysene, benzo[k]fluorancene and benzo[b]fluorancene, on the activities of hepatic and pulmonary CYP enzymes were investigated in male ICR mice. When mice were treated intraperitoneally with 3, 10 and 30 mg/ kg of individual PAHs for 3 consecutive days, the activities of ethoxyresorufin- and methoxyresorufin- O-dealkylases were significantly and differentially induced in both liver and lung. Moreover, other CYP isozyme-associated monooxygenase activities were also induced significantly in liver and lung with characteristic induction profiles. Our present results suggest that individual PAHs might have inductive effects on CYP isozymes, and that the characteristic inductive effects of individual PAHs on certain CYP isozymes would be developed as a marker for determining exposure to certain PAHs.