Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

The relationship between aerobic capacity and the recruitment of activated sweat gland density with passive heating

( Tae Wook Kim ),( Jong Hyuck Kim ),( Nam Eun Bae ),( Hyung Seok Seo ),( Young Soo Baik ),( Jeong Beom Lee ),( Hun Mo Yang ),( Young Ki Min ) 한국운동영양학회 2012 Journal of exercise nutrition & biochemistry Vol.16 No.4

This study investigated whether the recruitment of activated sweat gland density during passive heating [immersion of the lower body into hot water, 41℃ for 30 min (PH), room temperature 23 ± 0.5℃ with 60 ± 3% relative humidity] is different in endurance-trained (Trainee), compared with that of untrained subjects (Control), as indicated by VO2max. Eight trainees and seven control female subjects (38.31 ± 4.91 ml·kg-1·min-1 and 31.8 ± 0.92 ml·kg-1·min-1, respectively, p < 0.01) were similar on all other physical characteristics. To compare the changes between the trainees and controls, serum cortisol and prolactin (PRL), tympanic temperature (TYMP), local activated sweat gland density (L-ASGD) and the mean whole body sweat loss volume (M-WBSLV) changes were measured after PH. The cortisol was significantly higher (p < 0.05) and the PRL tended to be higher in the Trainee than in the Control. The TYMP increased more in the Trainee than in the Control (p < 0.001). The L-ASGD showed a higher tendency in the Trainee than in the Control, there was a significant difference in the mean activated sweat gland density (p < 0.01) and the L-ASGD was significantly correlated with the VO2max (p < 0.001). The M-WBSLV was significantly higher in the Trainee (p < 0.001) and significantly correlated with the VO2max (p < 0.001). The results suggest that in humans, a high aerobic capacity is associated with a greater recruitment of activated sweat glands, whole body loss of volume and TYMP. Therefore, the decline in the heat loss responses, due to decrease in maximal oxygen consumption, may be masked by repeated endurance exercise training.

초기 자궁내막암 환자에서의 복강경유도하 질식 자궁절제술과 복식 자궁절제술에 대한 비교 연구

김민규 ( Min Kyu Kim ),최동석 ( Dong Seok Choi ),김우영 ( Woo Young Kim ),최철훈 ( Chel Hun Choi ),김태중 ( Tae Joong Kim ),이정원 ( Jeong Won Lee ),김병기 ( Byoung Gie Kim ),이제호 ( Je Ho Lee ),배덕수 ( Duk Soo Bae ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12

Objective: To compare laparoscopic surgery with conventional abdominal surgery in patients with early stage endometrial cancer. Methods: A retrospective review of 63 patients with early stage endometrial cancer managed between March 2003 and May 2005. Two groups were defined whether they had been treated by laparoscopy (case group: n=26) or by laparotomy (control group: n=37). We compared age, body mass index (BMI), hemoglobin change, operation time, number of pelvic lymph nodes, hospital stay, case with adjuvant treatment and recurrence between two groups. Results: There was no statistical difference in characteristics (age, BMI, nulliparity, previous abdominal surgery, FIGO stage, histologic grade). between case and control group. In addition, there was no statistical difference in operation data and outcomes between two groups. Hemoglobin changes were 1.1 g/dL (case group) vs 1.7 g/dL (control group) (p=0.072). Operation time was 131 min vs. 115 min. The numbers of lymph nodes obtained were 8.7 vs 7.7 (right) 9.2 vs. 7.6 (left). Hospital stays were 8.4 vs. 9.2 days. Adjuvant treatment cases were 7 vs. 15. Recurrent case was one in each group. Two patients initially evaluated by laparoscopy were converted to laparotomy due to bleeding and adhesion. Conclusion: Laparoscopic surgery for treatment of early endometrial cancer is a safe and effective alternative to laparotomy . However, long-term survival and risk of recurrence have yet to be determined.

COPA(cuffed oropharyngeal airway)를 이용한 마취 유도 시 근이완제 사용 유무에 따른 반응

김상태,배진호,김상범,임승운,민병상,신영덕 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.3

Background : COPA (cuffed oropharyngeal airway) is a convenient device for airway management in patients undergoing general anesthesia for elective surgery in supine position. It causes less pharyngeal trauma than LMA(Laryngeal mask airway). The purpose of this study was to compare the effect of COPA with and without muscle relaxant. Methods : Forty patients with ASA physical status I and II for elective surgery were randomly assigned to two groups. Anaesthesia was induced with propofol (2 mg/kg) and vecuronium (1.5 mg/kg) and was administered intravenously in Group I but not in Group II. Mask ventilation was done for 5 min with 0: 5 L/min. COPA was placed and heart rate, and systolic, mean, diastolic blood pressure and peak inspiratory pressure were measured at 1 min interval for 5 min. Anaesthesia was maintained with pro- pofol 150 ㎍/kg/min, fentanyl 1 ㎍/kg/hr, O_2 2 L/min and N_2O 2 L/min. Results : There were no significant differences between Group I and Group II in heart rate, systolic, mean and dstolic blood pressure. PIP (Peak inspiratory pressure) was increased and hiccups occurred significantly (p $lt; 0.05) in Group II. Complete airway obstruction occurred in one patient of Group I and severe coughing, body movements and gagging occurred during induction and insertion in Group II. conclusions : With the use of appropriate muscle relaxant, we can use COPA without increased inspiratory pressure or significant complication. (Korean J Anesthesiol 2000; 38: 399~403)

허혈성 심질환에 있어서 아데노신 급속 정맥투여후 관동맥압의 변화에 관한 연구

봉종대,오종용,배성한,신원용,김철현,이광희,최태명,현민수,김성구,권영주 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Background: Adenosine interacts with A1 receptors present on the extracellular surface of cardiac cells, activating K+channels in a fashion. It produces coronary vasodilatation and AV nodal block. The half-time is one to six second and has ultra-short action. In ischemic heart disease, fractional flow reserve(FFR) can be achieved safely with intravenous adenosine infusions at a rate of 150㎍/kg/min which cause maximal coronary hyperemia. Purpose: We investigated the patients who have had ischemic heart disease(n=8). After adenosine intravenous administration(150㎍/kg/min), the effect cause maximal hyperemia of coronary artery. During peak maximal hyperemia, we reported clinical findings, coronary hemodynamics and electrocardiogram findings. Methods: After diagnostic coronary angiography and left ventriculography, catheter was advanced into the ostium of coronary artery. We investigated coronary hemodynamics such as systolic coronary artery pressure, diastolic coronary artery pressure, mean coronary artery pressure and heart rate. To assess the use of adenosine for determination of fractional flow reserve, hemodynamics and electrocardiogram were measured at basal state and during peak maximal hyperemia. Results: Symptoms developed 1.5-2 minute after adenosine intravenous administration and each symptom disappeared 2-2.5 minute after adenosine administration. Two patients represented asymptomatic appearance and six patients complained of flushing, chest pain, palpitation and headache. In eight patients with ischemic heart disease, 1.5 minute after venous administration of 150㎍/kg/min of adenosine, coronary artery pressure decreased and heart rate increased significantly. Conduction abnormalities after administration of 150㎍/kg/min of adenosine were transient 2nd degree AV block 2 cases(25%). Conclusions: Adenosine is a potent ultra short-acting vasodilator. Although coronary artery pressure decreased and heart rate increased and mild cardiovascular symptoms occurred after continuous infusion of 150㎍/kg/min of adenosine, it is useful as an agent for determination of fractional flow reserve.

Cutting performance of tungsten carbide tools coated with diamond thin films after etching for various times

Kim, Jong Seok,Park, Yeong Min,Bae, Mun Ki,Kim, Chi Whan,Kim, Dae Weon,Shin, Dong Chul,Kim, Tae Gyu World Scientific Publishing Company 2018 Modern physics letters. B, Condensed matter physic Vol.32 No.20

<P>In this study, diamond thin films were deposited on tungsten carbide tools using surface-wave plasma-enhanced chemical vapor deposition (SWP-CVD). To eliminate the adverse effects of cobalt on the diamond deposition process, the cobalt was removed from the surface of the tools by etching with Murakami’s reagent for various times (30, 60, and 120 min). The cutting performance of the untreated and the diamond-coated WC tools was examined by performing cutting test on carbon fiber-reinforced plastic (CFRP). The results showed that all the diamond-coated tools exhibited great improvement on the durability and wear resistance compared to the uncoated one. In addition, the diamond-coated tool lift time is found to be proportional to the etching time. An increase more than twofold has been achieved when the etch time was increased from 30 min to 120 min.</P>

광중합형 복합레진 제조시의 압축강도에 관한 실험적 연구

배태성,추용호,채민수 大韓齒科器材學會 1995 대한치과재료학회지 Vol.22 No.2

This study was performed to elaluate the effect of matrix resins and fillers on the compressive strength of light-activated composite resins. Four different types of composites were made by mixing the inorganic fillers of armorphous spherical silica and crushed quartz with resins of BisGMA/TEGDMA and UTeMA/TEGDMA. The specimens of 3mm in diameter and 6mm in length were prepared. Compressive test was subjected to a crosshead speed of 0.5mm/min and fracture surfaces were examined by SEM. The results obtained were summarized as follows; 1. Compressive strength of the UTeMA-based composite resin with spherical filler was superior to the other composite resins(p<0.01). 2. Compressive strength of the BisGMA-based composite resins with significantly decreased after immersion in water for 7 days(p<0.05). 3. UTeMA-based composite resins showed the aspect of decrease in compressive strength after cold storage at 5℃.

표고 버섯 중의 Branched chain amino acid Aminotransferase 의 분리정제 및 그 성질에 관한 연구

배강규,민태진,이수용 동국대학교 자연과학연구소 1987 자연과학연구 논문집 Vol.7 No.-

표고버섯중의 branched chain amino acid aminotransferase〔BCAT(EC 2,6,1,42)〕를(NH₄)₂SO₄ 분별침전, DEAE-cellulose column chromatography 및 sephades G-150겔 여과로 정제하여 그 특성을 조사하였다. 이 효소의 최적 pH는 8.5, 최적 온도는 36℃였고, 20℃이하에서 30분동안 열에 안정하였다. 이효소의 분자량은 69,000dalton이었으며, 산 가수분해하여 아미노산을 분석한 결과 18종의 서로 다른 아미노산들로 구성되어 있었다. 이 효소는 가지달린 아니노산인 L-valine, L-leucine 및 L-isoleucine에 대해서 특이성을 보였으며 phenylamine, potassium cyanide, phenylhydrazine, N-ethylmaleimide 및 p-chloromercuribenzoate에의하여 효소활성이 억제되었다. 또 한, L-leucine, a-ketoglutarate 및pyridoxal-5-phosphate에대한 이 효소의 Km값은 각 각 2.40mM, 2.98mM 및 1.74uM이었다. Branched cnain amino acid aminotransferaase 〔BCAT (EC 2.6.1.42)〕was purified by ammonium sulfate saturation. DEAE-cellulose column chromatography and sephadex G-150 gel filtration in Lentinus edodes(Berk.) Sing. Optimum pH and temperature were found to be 8.5 and 36℃, respectively. Apparent molecular weights of this enzyme was estimated 69.000 dalton by HPLC and SDS-PAGE. It showed activity toward L-leucine, L-isoleucine and L-valine as a substrate. It was ingibited by hydroxylamine, potassium cyanide, phenylgydrazine. N-ehylmaleimide, p-chloromercuribenzoate (CMB). cupric acetate and mercuric chloride. The Km values of this enzyme were determined to be 2.40mM for leucine, 2.98mM for a-ketoglutarate and 1.74μM for pyridexal-5- phospate, respectively.

필러의 종류가 UTMA 계 광중합형 복합레진의 강도에 미치는 영향

배태성,최진용,최규형,채민수 大韓齒科器材學會 2000 대한치과재료학회지 Vol.27 No.3

This study was performed to evaluate the effect of resin and filler type on the strength of light-activated composites. Experimental composites were prepared using the four types of urethane tetramethacrylate monomers(HM-4M, TM-4M, XY-4M and DC-4M) and three different shapes of silica fillers. Cylindrical specimens of 3㎜ in diameter and 6㎜ in length and rectangular specimens of 2×2×24㎜ were prepared for the compressive test and 3-point bend test, respectively. All specimens were immersed in distilled water at 37℃ for 24 hours. Compressive and 3-point bend tests were carried out at a crosshead speed of 0.5 ㎜/min and fracture surfaces were observed with scanning electron microscope. The results obtained were summarized as follows : 1. When the size distribution of fillers was same, composites containing the spherical fillers showed the relatively higher loading rate of fillers and compressive strength than those containing the crushed fillers. 2. Compressive strength values of the composites based on UTMA monomers containing the aliphatic UTMA monomers (HM-4M and TM-4M) showed the relatively higher strength values than those of the composites based on UTMA monomers containing the aromatic or cyclohexane ring in their chemical structure(XY-4M and DC-4M). 3. The compressive and transverse strength values of UTMA-based composites were higher than those of Bis-GMA-based composites. 4. According to the microscopic observation of fracture surfaces, composite failure developed along the matrix resin and resin/filler interface region.

초전도 코일의 �치 시뮬레이션 해석

배준한,주민석,고태국 연세대학교 대학원 1994 延世論叢 Vol.30 No.1

This thesis is a study on the quench characteristics in epoxy impregnated superconducting magnet. Teh normal 3one propagation velocity, full quench time and full recovery time in a superconducting magnet during quench are simulated numerically. Propagation velocity is linearly proportional to the transport current and abruptly increases near the critical current. Longitudinal velocity is nearly 20 times of transverse velocity regardless of the transport current. The ratio of the transverse velocity to longitudinal velocity is about 0.04 regardless of the transport current and the full quench time is abruptly decreased near the minimum propagation current. Comparing superconducting composites composed of Cu matrix to the composites of Cu/CuNi matrix, the propagation velocity of the former is slower than the latter, while the full quench time of the former is longer under the same transport curent.