http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Xianfeng Gong,Minwei Wang,Shin-ichi Tashiro,Satoshi Onodera,Takashi Ikejima 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.4
A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor SP600125 decreased p53 protein expression during exposure to pseudolaric acid B. SP600125 decreased the phosphorylation of p53 during pseudolaric acid B exposure, indicating that JNK mediates phosphorylation of p53 during the response to pseudolaric acid B. SP600125 reversed pseudolaric acid B-induced down-regulation of phosphorylated extracellular signal-regulated pro-tein kinase (ERK), and protein kinase C (PKC) was activated by pseudolaric acid B, whereas stau-rosporine, calphostin C, and H7 partly blocked this effect. These results indicate that p53 is partially regulated by JNK in pseudolaric acid B-induced HeLa cell death and that PKC participates in pseudolaric acid B-induced HeLa cell death.
Toshihisa Sato,Motoyuki Akamatsu,Nobuhiro Imacho,Takashi Sato,Yuji Munehiro,Yoshiyuki Yoneyama,Yoshiyuki Tashiro 한국자동차공학회 2008 한국자동차공학회 Symposium Vol.2008 No.9
This paper describes an investigation of driver’s behavior assessment while driving on downgrades with different gradients and effect of road safety countermeasures using a coloured pavement or a light-emitting delineator. The driving simulator used in the experiments consists of 300-degree fields of view screen, a hexapod motion platform, a sound system with spatial placed eight speakers, and so on. The target was two kinds of downgrades after curved and more gradual downgrade section: one is the existent downgrade with 8% gradient and with one traffic lane in each direction, and another has 7% gradient with two lanes that will be constructed for improvement of the existing downgrade. The existent downgrade has a temporary road structure and we investigated the effective countermeasures of the coloured pavement or a light-emitting delineator to reduce driving speed on the temporary downgrade. The simulator precisely represented these road structures using CAD data of the real and planned roads. Two downgrade sections were connected each other in one experimental route in order to compare the driving between on different downgrades and the driving with and without the countermeasures. The results of participated 31 drivers suggest that there are almost no differences in road safety between the existent and improved downgrades in terms of objective and subjective assessments. The evaluation results of the effect of the countermeasures imply the necessity of the interface design that affords drivers easy recognition of onset location of the steep downgrade.
Gong Xian-Feng,Wang Min-Wei,Tashiro Shin-Ichi,Onodera Satoshi,Ikejima Takashi The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.1
Pseudolaric acid B is a major compound found in the bark of Pseudolarix kaempferi Gordon. In our study, pseudolaric acid B inhibited growth of human melanoma cells, A375-S2 in a time and dose-dependent manner. A375-S2 cells treated with pseudolaric acid B showed typical characteristics of apoptosis including morphologic changes, DNA fragmentation, sub-diploid peak in flow cytometry, cleavage of poly-ADP ribose polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD). P53 protein expression was upregulated while cells were arrested at the $G_2/M$ phase of the cell cycle. There was a decrease in the expression of anti-apoptotic Bcl-2 and Bcl-xL proteins, whereas pro-apoptotic Bax was increased. The two classical caspase substrates, PARP and ICAD, were both decreased in a time-dependent manner, indicating the activation of downstream caspases.
Xian-Feng Gong,Min-Wei Wang,Shin-Ichi Tashiro,Satoshi Onodera,Takashi Ikejima 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.1
Pseudolaric acid B is a major compound found in the bark of Pseudolarix kaempferi Gordon. In our study, pseudolaric acid B inhibited growth of human melanoma cells, A375-S2 in a timeand dose-dependent manner. A375-S2 cells treated with pseudolaric acid B showed typical characteristics of apoptosis including morphologic changes, DNA fragmentation, sub-diploid peak in flow cytometry, cleavage of poly-ADP ribose polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD). P53 protein expression was upregulated while cells were arrested at the G2/M phase of the cell cycle. There was a decrease in the expression of anti-apoptotic Bcl-2 and Bcl-xL proteins, whereas pro-apoptotic Bax was increased. The two classical caspase substrates, PARP and ICAD, were both decreased in a time-dependent manner, indicating the activation of downstream caspases.
L-Leucine increases the daily body temperature and affords thermotolerance in broiler chicks
Guofeng Han,Hui Yang,Yunhao Wang,Shogo Haraguchi,Takuro Miyazaki,Takashi Bungo,Kosuke Tashiro,Mitsuhiro Furuse,Vishwajit S. Chowdhury 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.6
Objective: Heat stress poses an increasing threat for poultry production. Some amino acids have been found to play critical roles in affording thermotolerance. Recently, it was found that in ovo administration of L-leucine (L-Leu) altered amino acid metabolism and afforded thermotolerance in heat-exposed broiler chicks. Methods: In this study, two doses (35 and 70 μmol/egg) of L-Leu were administered in ovo on embryonic day 7 to determine their effect on rectal temperature (RT), body weight (BW) and thyroid hormones at hatching. Changes in RT, BW, and thermotolerance in post-hatched chicks were also analyzed. Results: It was found that in ovo administration of L-Leu dose-dependently reduced RT and plasma thyroxine (T4) level just after hatching. In post-hatched neonatal broiler chicks, however, the higher dose of L-Leu administered in ovo significantly increased RT without affecting BW gain. In chicks that had been exposed to heat stress, the RT was significantly lowered by in ovo administration of L-Leu (high dose) in comparison with the control chicks under the same high ambient temperature (HT: 35°C±1°C, 120 min). Conclusion: In ovo administration of L-Leu in a high dose contributed to an increased daily body temperature and afforded thermotolerance under HT in neonatal broiler chicks.
Timosaponin AIII induces apoptosis and autophagy in human melanoma A375-S2 cells
Ye Wang,Lei Xu,Li-Li Lou,Shao-Jiang Song,Guo-Dong Yao,Meng-Yao Ge,Toshihiko Hayashi,Shin-ichi Tashiro,Satoshi Onodera,Takashi Ikejima 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1
Timosaponin AIII (AIII), a steroidal saponinisolated from Anemarrhena asphodeloides Bge. Our studyshowed that AIII induced both apoptosis and autophagy,and autophagy inhibited apoptosis in A375S2 cells. Furtherly,this study was carried out to investigate what kindof cytokines plays an important role in this process. Theresults revealed that AIII induced apoptosis through activatingc-Jun N-terminal protein kinase (JNK) or extracellularsignal related kinase (ERK) signaling pathway andgenerating NO. However, JNK or ERK inhibited autophagy,while NO had no effect on autophagy. Therefore,JNK, ERK or NO regulates two programmed death processesin different ways. AIII did not show obvious cytotoxiceffect on human peripheral blood mononuclear cells,which indicated that AIII has less side effects on normalcells, and could be considered as a leading compound fordeveloping novel anticancer drug.