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Katsurano, M,Niwa, T,Yasui, Y,Shigematsu, Y,Yamashita, S,Takeshima, H,Lee, M S,Kim, Y-J,Tanaka, T,Ushijima, T Macmillan Publishers Limited 2012 Oncogene Vol.31 No.3
Epigenetic fields for cancerization are involved in development of human cancers, especially those associated with inflammation and multiple occurrences. However, it is still unclear when such field defects are formed and what component of inflammation is involved in induction of aberrant DNA methylation. Here, in a mouse colitis model induced by dextran sulfate sodium (DSS), we identified three CpG islands specifically methylated in colonic epithelial cells exposed to colitis. Their methylation levels started to increase as early as 8 weeks after DSS treatment and continued to increase until colon cancers developed at 15 weeks. In contrast to the temporal profile of DNA methylation levels, infiltration of inflammatory cells spiked immediately after the DSS treatment and then gradually decreased. Exposure of cultured colonic epithelial cells to DSS did not induce DNA methylation and it was indicated that inflammation triggered by the DSS treatment was responsible for methylation induction. To clarify components of inflammation involved, severe combined immunodeficiency (SCID) mice that lack functional T- and B-cells were similarly treated. Even in SCID mice, DNA methylation, along with colon tumors, were induced at the same levels as in their background strain of mice (C.B17). Comparative analysis of inflammation-related genes showed that Ifng, Il1b and Nos2 had expression concordant with methylation induction whereas Il2, Il6, Il10, Tnf did not. These results showed that an epigenetic field defect is formed at early stages of colitis-associated carcinogenesis and that functional T and B cells are non-essential for the formation.
Natural frequencies and mode shapes of thin-walled members with shell type cross section
T. Shigematsu,T. Hara,M. Ohga 국제구조공학회 2002 Steel and Composite Structures, An International J Vol.2 No.3
An analytical procedure based on the transfer matrix method to estimate not only the natural frequencies but also vibration mode shapes of the thin-walled members composed of interconnected cylindrical shell panels is presented. The transfer matrix is derived from the differential equations for the cylindrical shell panels. The point matrix relating the state vectors between consecutive shell panels are used to allow the transfer procedures over the cross section of the members. As a result, the interactions between the shell panels of the cross sections of the members can be considered. Although the transfer matrix method is naturally a solution procedure for the one-dimensional problems, this method is well applied to thin-walled members by introducing the trigonometric series into the governing equations of the problem. The natural frequencies and vibration mode shapes of the thin-walled members composed of number of interconnected cylindrical shell panels are observed in this analysis. In addition, the effects of the number of shell panels on the natural frequencies and vibration mode shapes are also examined.
Modeling of Lithium-Ion Batteries with Constant Phase Element and Butler-Volmer’s Equation
T. Yamahigashi,J. Shimura,K. Shibuya,Y. -H. Wu,K. Shigematsu,T. Hosotani,J. Kuromi,J. Imaoka,M. Yamamoto 전력전자학회 2023 ICPE(ISPE)논문집 Vol.2023 No.-
An equivalent circuit model of lithium-ion batteries which has a nonlinear resistor governed by Butler- Volmer’s equation and a constant phase element was investigated. The current dependence of the real battery could be reproduced well by the contribution of the nonlinear resistor, and the transient response of voltage could be reproduced well by the contribution of the constant phase element.
Effects of initial imperfections on nonlinear behaviors of thin-walled members
Ohga, M.,Takaue, A.,Shigematsu, T.,Hara, T. Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.11 No.5
The effect of the initial imperfections on the nonlinear behaviors and ultimate strength of the thin-walled members subjected to the axial loads, obtained by the finite element stability analysis, are examined. As the initial imperfections, the bucking mode shapes of the members are adopted. The buckling mode shapes of the thin-walled members are obtained by the transfer matrix method. In the finite element stability analysis, isoparametric degenerated shell element is used, and the geometrical and material nonlinearity are considered based on the Green Lagrange strain definition and the Prandtl-Reuss stress-strain relation following the von Mises yield criterion. The U-, box- and I-section members subjected to the axial loads are adopted for numerical examples, and the effects of the initial imperfections on the nonlinear behaviors and ultimate strength of the members are examined.
Jeong, H.,Kim, J.S.,Song, S.,Shigematsu, H.,Yokoyama, T.,Hyun, J.,Ha, N.C. Current Biology 2016 Structure Vol.24 No.2
<P>The resistance-nodulation-division type tripartite pump AcrAB-TolC and its homologs are responsible for multidrug resistance in Gram-negative bacteria by expelling a wide variety of toxic substrates. The three essential components, AcrA, AcrB, and TolC, must function in concert with each respective binding partner within the complex. In this study, we report an 8.2-angstrom resolution cryo-electron microscopy (cryo-EM) 3D reconstruction of the complex that consists of an AcrAB fusion protein and a chimeric TolC protein. The pseudoatomic structure derived from the cryo-EM reconstruction clearly demonstrates a model only compatible with the adaptor bridging mechanism, wherein the funnel-like AcrA hexamer forms an intermeshing cogwheel-like interaction with the alpha-barrel tip region of TolC. These observations provide a structural milestone for understanding multidrug resistance in pathogenic Gram-negative bacteria, and may also lead to the design of new antibacterial drugs.</P>