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      • SCOPUS

        Analysis of Chromosome Lesions in Women with Benign Breast Diseases, Residing in the Territories Contaminated as a Result of the Chernobyl Accident

        Ivanova, T.,Smirnova, I.,Kondrashova, T.,Yun, Yeon Sook,Song, Jie Young,Han, Young Soo Trans Tech Publications, Ltd. 2005 Key Engineering Materials Vol.277 No.-

        <P>Spontaneous levels of the chromosome aberrations in the peripheral lymphocytes of 173 women were analyzed in the course of a medical examination of the residents of the Bryansk District territories (Klintsy Region, and the town of Klintsy) contaminated after the Chernobyl NPP accident in April 1986. The study population included only women who had been premenopausal at the time of the accident (mean age in 1986 was 23.9±0.7 years, ranging 2 to 56 years). The territory contamination with 137Cs ranged from 1.8 to 23.7 Ci/km2, the mean value being 7.5±0.2 Ci/km2. The range of the calculated absorbed thyroid doses was 30 to 340 mGy (in average, 52.3±3.3 mGy). The number of women with benign breast diseases (BBD) was 116 (67%). All recognizable chromosome lesion types were scored in the first in vitro division metaphases stained with azure-eosin. The mean total aberration frequency in the sample studied was 3.5±0.2 per 100 metaphases, the main contribution being made by the chromatid deletions, which is typical for a normal spontaneous aberration pattern. Based on the results of the cytogenetic analysis, the study population was subdivided into two groups. Group A (128 women) included subjects who showed normal patterns of spontaneous chromosome aberrations. Abnormal patterns, including the aberration frequencies significantly (at p<0.05) exceeding the mean group value and/or the presence of chromosome type exchange aberrations, were found in 45 women (group B). Statistical hypotheses on the possible correlations between the cytogenetic anomalies, BBD, level of the territory radiation contamination, and the absorbed thyroid dose were tested. The proportion of women with BBD was approximately the same in groups A and B (68 and 64%, respectively; p=0.665), which did not allow us to state that abnormal chromosome patterns can be used as diagnosis markers. The data obtained showed some positive trends between the cytogenetic anomalies, breast disorders, level of the territory contamination and the thyroid dose. In addition, it is interesting to note that the inclusion of the body mass index (BMI) into the data analysis showed that, both in women with cytogenetic anomalies (group B) and among the women with BBD, this index was essentially lower than in the respective comparison groups. The BMI differences could not be explained by the age differences, since the latter were insignificant in all the cases (p>0.8).</P>

      • KCI등재

        Impact of Cross-Section-Covariance Data on Results of High-Confidence Criticality Validation

        T. Ivanova,I. Duhamel,E. Letang 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

        Neutron cross-section-covariance data are used for high-confidence criticality validation based upon ``adjustment'' method. To investigate how they impact results of the validation study, three sets of the covariance data (ENDF/B-V, JENDL-3.2, and TENDL-2009) were used to establish prior and posterior (post-adjusted) uncertainties for application cases with typical uranium dioxide fuel used in criticality safety analysis. Data from the French Fission Product integral experiments were used for the adjustment. The experiments were thoroughly selected and analysed to establish correlation between experimental uncertainties. It is shown the k_(eff) uncertainties due to the original covariance data differ significantly. While the post-adjusted k_(eff) uncertainties decrease significantly and are similar, irrespective of the initial matrices, for the applications systems which are similar to the experiments in k_(eff) sensitivities to nuclear data. This demonstrates a prevalent role of the integral experiments in the uncertainty assessment with the adjustment technique if enough reliable experiments are available. Three sets of full initial and post-adjusted matrices of contributions to overall k_(eff) uncertainties due to neutron cross sections are compared. The comparison shows that the post-adjusted uncertainties are decreased because of negative cross-correlations, which appear between reactions for the same and different isotopes, rather than because of reduction of uncertainties.

      • SCIESCOPUSKCI등재

        Genetic Contribution of Indigenous Yakutian Cattle to Two Hybrid Populations, Revealed by Microsatellite Variation

        Li, M.H.,Nogovitsina, E.,Ivanova, Z.,Erhardt, G.,Vilkki, J.,Popov, R.,Ammosov, I.,Kiselyova, T.,Kantanen, J. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.5

        Indigenous Yakutian cattle' adaptation to the hardest subarctic conditions makes them a valuable genetic resource for cattle breeding in the Siberian area. Since early last century, crossbreeding between native Yakutian cattle and imported Simmental and Kholmogory breeds has been widely adopted. In this study, variations at 22 polymorphic microsatellite loci in 5 populations of Yakutian, Kholmogory, Simmental, Yakutian-Kholmogory and Yakutian-Simmental cattle were analysed to estimate the genetic contribution of Yakutian cattle to the two hybrid populations. Three statistical approaches were used: the weighted least-squares (WLS) method which considers all allele frequencies; a recently developed implementation of a Markov chain Monte Carlo (MCMC) method called likelihood-based estimation of admixture (LEA); and a model-based Bayesian admixture analysis method (STRUCTURE). At population-level admixture analyses, the estimate based on the LEA was consistent with that obtained by the WLS method. Both methods showed that the genetic contribution of the indigenous Yakutian cattle in Yakutian-Kholmogory was small (9.6% by the LEA and 14.2% by the WLS method). In the Yakutian-Simmental population, the genetic contribution of the indigenous Yakutian cattle was considerably higher (62.8% by the LEA and 56.9% by the WLS method). Individual-level admixture analyses using STRUCTURE proved to be more informative than the multidimensional scaling analysis (MDSA) based on individual-based genetic distances. Of the 9 Yakutian-Simmental animals studied, 8 showed admixed origin, whereas of the 14 studied Yakutian-Kholmogory animals only 2 showed Yakutian ancestry (>5%). The mean posterior distributions of individual admixture coefficient (q) varied greatly among the samples in both hybrid populations. This study revealed a minor existing contribution of the Yakutian cattle in the Yakutian-Kholmogory hybrid population, but in the Yakutian-Simmental hybrid population, a major genetic contribution of the Yakutian cattle was seen. The results reflect the different crossbreeding patterns used in the development of the two hybrid populations. Additionally, molecular evidence for differences among individual admixture proportions was seen in both hybrid populations, resulting from the stochastic process in crossing over generations.

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