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      저자 : Syeda Mashnia Tasnim (검색결과 1 건)
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        Evaluation of Bonamia semidigyna (Roxb.) for antioxidant, antibacterial, anthelmintic and cytotoxic properties with the involvement of polyphenols

        Md. Adnan,Md. Nazim Uddin Chy,Sajib Rudra,Afroza Tahamina,Raju Das,Mohammad Akramul Hoque Tanim,Tanvir Iqram Siddique,Asadul Hoque,Syeda Mashnia Tasnim,Arkajyoti Paul,A. T. M. Mostafa Kamal 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.2

        This study was conducted to investigate the antioxidant, antibacterial, anthelmintic, and cytotoxic activities of the crude methanol extract of Bonamia semidigyna (Roxb.) leaves and its derived fractions in different experimental models. Leaves of B. semidigyna were extracted with methanol (MBS) and the resultant successively fractionated into n-hexane (NBS), petroleum ether (PBS), chloroform (CBS), and ethyl acetate (EBS) soluble fractions. Later, the plant extractives were investigated for antioxidant, antibacterial, anthelmintic and cytotoxic properties. Phytochemical study was carried out using standard methods and polyphenols content were determined by spectrophotometric techniques. Antioxidant activity was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, hydrogen peroxide ( H2O2) scavenging activity, ferric reducing power, and total antioxidant capacity assays. Disc diffusion technique used to evaluate the antibacterial efficacy and anthelmintic activity was determined using aquarium worm (Tubifex tubifex) whereas cytotoxicity was evaluated using brine shrimp lethality bioassay. The phytochemical study revealed the presence of alkaloids, flavonoids, terpenoids, tannins, saponins, phenolic, steroids, sterols, quinones, oxalate, coumarins, and emodins in the plant extractives. In addition, the quantitative phytochemical analysis showed the significant amount of polyphenol contents. In antioxidant assays, the crude methanol extract and EBS fraction exhibited the most potent antioxidant activity among all the extractives. The crude methanol extract and EBS fraction also possessed significant antibacterial and anthelmintic potentials while moderate cytotoxic activities were found for all the plant extractives. The present study confirmed that the crude methanol extract of B. semidigyna and its EBS fraction, possibly due to its high polyphenol contents possess significant antioxidant, antibacterial, and anthelmintic properties.

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