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Kim, Suyong,Dangol, Manita,Kang, Geonwoo,Lahiji, Shayan F.,Yang, Huisuk,Jang, Mingyu,Ma, Yonghao,Li, Chengguo,Lee, Sang Gon,Kim, Chang Hyun,Choi, Young Wook,Kim, So Jeong,Ryu, Ja Hyun,Baek, Ji Hwoon,K American Chemical Society 2017 Molecular Pharmaceutics Vol.14 No.6
<P>Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated in a biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the encapsulated drugs into the body. However, because of limited loading capacity of drugs within microsized structures, only a small dosage can be delivered, which is often insufficient for patients. We propose a novel DMN application that combines topical and DMN application simultaneously to improve skin permeation efficiency. Drugs in pretreated topical formulation and encapsulated drugs in DMN patch are delivered into the skin through microchannels created by DMN application, thus greatly increasing the delivered dose. We used 4-n-butylresorcinol to treat human hyper pigmentation and found that sequential application of serum formulation and DMNs was successful. In skin distribution experiments using Alexa Fluor 488 and 568 dyes as model drugs, we confirmed that the pretreated serum formulation was delivered into the skin through microchannels created by the DMNs. In vitro skin permeation and retention experiments confirmed that this novel combined application delivered more 4-n-butylresorcinol into the skin than traditional DMN-only and serum-only applications. Moreover, this combined application showed a higher efficacy in reducing patients' melanin index and hyperpigmented regions compared with the serum-only application. As combined application of DMNs on serum-treated skin can overcome both dose limitations and safety concerns, this novel approach can advance developments in transdermal drug delivery.</P>
Kim, Kyung Oh,Shin, Suyong,Kim, Junyong,Choi, Tae-Lim American Chemical Society 2014 Macromolecules Vol.47 No.4
<P>Living ROMP of monomers containing <I>endo</I>-tricyclo[4.2.2.0<SUP>2,5</SUP>]deca-3,9-diene (TD) moieties was successfully performed using thermally stable second generation Grubbs and Hoveyda–Grubbs catalysts. Even slow-initiating catalysts enabled the living polymerization to give polymers with a narrow polydispersity index and controlled molecular weight because the unique structure of the TD monomers resulted in much faster initiation and slower propagation than conventional norbornene monomers. Kinetic analyses confirmed that the ratio of initiation/propagation rate (<I>k</I><SUB>i</SUB>/<I>k</I><SUB>p</SUB>) of the TD monomers was 10 to 200 times larger than that of norbornene derivatives. To demonstrate the living nature of the ROMP, block copolymers were successfully prepared using second generation Hoveyda–Grubbs catalyst for the first time. In addition, three-arm star polymers were prepared by core-first approach using Hoveyda–Grubbs type three-arm initiator, owing to the living ROMP of TD monomers with this stable catalyst. Also, star diblock copolymer was prepared with precise molecular weight and narrow PDI of 1.03. Since these star polymers contained bulky second or third generation dendrons, these dendronized three-arm star polymers were visualized under atomic force microscopy (AFM) to confirm the star-shape topology.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mamobx/2014/mamobx.2014.47.issue-4/ma5000333/production/images/medium/ma-2014-000333_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ma5000333'>ACS Electronic Supporting Info</A></P>
Kim, Yonggi,Kim, Hyeon Ji,Cho, Wanil,Ko, Sanghoon,Park, Sung Kwon,Lee, Suyong Food & Nutrition Press 2017 Journal of texture studies Vol.48 No.5
<P>Practical applicationsAs the elderly population is increasing throughout the world, there are growing interests in developing food products for older adults with difficulties in chewing and swallowing in the food industry. In this study, the instrumental texture of solid foods in a starch gel system was correlated with the sensory properties perceived by the people aged 60 and older. Based on the principal component analysis, the corn starch gel samples with different hardness were classified into the five groups that were presented with the ranges of stress values. The results obtained in this study may thus provide valuable information on the standard criteria and guidelines customized for the elderly.</P>
Utilization of brown rice flour as a functional ingredient in instant fried noodles
Kim, Hyeon Ji,Baek, Jeong-Ju,Min, Byung-Jung,Kim, Jong Hoon,Yoo, Sang-Ho,Lee, Suyong The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.5
Brown rice flour was utilized as a functional ingredient in instant fried noodles and their quality attributes were characterized from the standpoint of physicochemical characteristics. The pasting results showed that there was an increasing tendency in the peak, trough, and final viscosities of wheat flour with increasing amounts of brown rice flour. The thermal conductivity of the noodle dough with brown rice flour had a lower value of thermal conductivity. When the noodles were subjected to frying, the brown rice flour did not play a negative role in the oil absorption of the instant fried noodles. The use of brown rice flour contributed to retarding the oxidative deterioration of the instant fried noodles during storage. While the breaking stress of instant fried noodles before cooking increased with increasing amount of brown rice flour, the tensile properties of the noodles were lowered after cooking.
Kim, Suyong,Lee, Jeongwon,Shayan, F. Lahiji,Kim, Seohyun,Huh, Inyoung,Ma, Yonghao,Yang, Huisuk,Kang, Geonwoo,Jung, Hyungil Elsevier 2018 Carbohydrate polymers Vol.180 No.-
<P><B>Abstract</B></P> <P>A dissolving microneedle (DMN) patch encapsulated with ascorbic acid 2-glucoside (AA2G) in a needle-shaped hyaluronic acid (HA) backbone was fabricated and sterilized by electron beam (e-beam, 5–40kGy) and gamma ray (γ-ray, 5–30kGy). DMN structures maintained their morphologies and fracture force regardless of e-beam and γ-ray irradiation doses. Both e-beam (40kGy) and γ-ray (20 and 30kGy) met the product sterility requirements for cosmetics and vaccines; however, γ-ray irradiation significantly degraded the encapsulated AA2G, while e-beam maintained AA2G activity. Thus, an e-beam dose of 40kGy, which satisfied the sterility requirements without loss of AA2G, is suitable for terminal sterilization of DMNs. Moreover, we confirmed that the optimized irradiation (e-beam, 40kGy) did not affect dissolution rate and drug release profile of DMNs. Further, we confirmed that HA, the backbone polymer of DMNs, could be utilized as a stabilizer that inhibits degradation of encapsulated AA2G by irradiation. This detailed analysis can be developed further to optimize various biological drugs in transdermal drug delivery systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hyaluronic acid-based dissolving microneedles were fabricated and sterilized. </LI> <LI> Electron beam (e-beam) and gamma ray (γ-ray) were used for sterilization. </LI> <LI> Irradiation did not affect morphology and fracture force of dissolving microneedles. </LI> <LI> E-beam and γ-ray reduced microorganismal contamination; γ-ray degraded the drug. </LI> <LI> Hyaluronic acid stabilizes and can inhibit degradation of the encapsulated drug. </LI> </UL> </P>
Kim, Nam-Hee,Kim, Jung-Hwan,Lee, Suyong,Lee, Heungsook,Yoon, Jae-Wook,Wang, Ren,Yoo, Sang-Ho WILEY-VCH Verlag 2010 Die Stärke Vol.62 No.7
<P>Normal corn starch (NCS) was treated by both autoclaving-cooling and cross-linking to produce resistant starch (RS). The RS yield, crystalline structure, as well as other physicochemical properties of the modified starch were investigated. The yield of RS was 12.2% by four autoclaving-cooling cycles, and it could be further increased up to 31.0% by the subsequent cross-linking using sodium trimetaphosphate/sodium tripolyphosphate. The scanning electron microscopy images clearly illustrated that the granular structure of native starch was disrupted and a continuous network with irregular shape was formed after autoclaving-cooling cycles. The subsequent chemical cross-linking appeared to make the network structure more compact and dense. X-ray diffraction patterns showed that B- and V-types coexisted in all the modified corn starches, and all these modified starches exhibited very low viscosity which remained almost constant regardless of temperature changes.</P>
Kim, Daehee,Kim, Ho-Jong,Shim, Seung-Bo,Jung, Suyong,Lee, Nam Hee,Nahm, Seung Hoon,Shin, Eui-Cheol,Yun, Wan Soo,Ha, Dong Han Institute of Pure and Applied Physics 2017 Japanese Journal of Applied Physics Vol. No.
<P>We report an electric conductance change in a graphene-based device upon molecular adsorption for detecting botulinum neurotoxin (BoNT) using the antibody-antigen binding strategy. This device consists of a 400-mu m-wide monolayer of graphene between the source and drain electrodes. As-fabricated devices exhibit p-type behaviors. After modifying graphene with linkers and antibodies, BoNT detection was performed by dropping a target solution and measuring the conductance change of the devices. The immobilization of linkers on graphene decreases the electrical conductance as a result of electron transfer from linkers to graphene. However, the conductance change caused by the adsorption of antibodies or BoNTs is ascribed to the top-gating effects of the molecules adsorbed on graphene. The normalized conductance change of the graphene-based device upon antibody-BoNT binding was greater than 5%. (C) 2017 The Japan Society of Applied Physics</P>