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Fabrication of microgrooved scaffolds using near-field electrospinning-assisted lithography (NFEAL)
Yang, SungYeun,Min, Ji Hong,Cho, Kanghee,Seo, Il Ho,Ryu, WonHyoung,Koh, Won-Gun Elsevier 2019 Journal of industrial and engineering chemistry Vol.80 No.-
<P><B>Abstract</B></P> <P>A simple patterning process combining near-field electrospinning (NFE) and template lithography, called near-field electrospinning-assisted lithography (NFEAL), was developed to prepare polymeric scaffolds with microgroove patterns for potential use in biomedical applications. NFE enabled the deposition of poly (ethylene oxide) (PEO) fibers at a desired position. The diameters of the deposited PEO fibers could be controlled over a range of 0.5–20μm by adjusting the NFE parameters such as voltage, distance, feed rate, and translation speed. The preparation of PEO fibers with 1 and 3μm diameters using NFE, followed by the deposition of polystyrene (PS) and removal of the fiber template, created free-standing PS scaffolds with microgroove patterns. The width of the microgroove was similar to the diameter of the PEO fibers. The depth of the microgroove was also dependent on the dimensions of the PEO fibers; microgrooves of depth 64.49±11.5nm and 216.68±62.9nm were fabricated from PEO fibers of diameters 1 and 3μm, respectively. When C2C12 cells were cultured on the microgrooved scaffolds, they showed enhanced elongation or alignment along the microgrooved scaffolds, especially, for the microgroove (1μm) with a smaller width.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
마이크로 채널의 웨팅을 이용한 생분해성 마이크로 유체 약물전달장치의 초기 분출 조절
양승연(SungYeun Yang),이강주(KangJu Lee),류원형(WonHyoung Ryu) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
Local and prolonged delivery of analgesics such as bupivacaine is greatly desired for post-operative pain management. For higher efficacy, it is required to maintain a constant rate of delivery of the analgesic drug over at least 2 ~ 3 days after surgery. We have developed a biodegradable micro-fluidic system that releases bupivacaine for a week for post operative pain management. In particular, we investigated the diffusive transport of bupivacaine through micro-channels of the system. However at the early stage of release, micro-channels in the devices made of relatively hydrophobic biodegradable polymer, 85/15poly(lactic-co-glycolic acid), were occupied with air bubbles such that aqueous release medium cannot move into the reservoir to dissolve bupivacaine in the solid phase. This leads to uncontrolled early stage release of the local analgesic from the devices. In order to avoid this issue, the release channels were wetted with a surfactant, polyethylene glycol(PEG) and its effect on the release characteristic is discussed in this presentation.