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Kwon, Hyun Woo,Kim, Jong Phil,Lee, Hong Jae,Paeng, Jin Chul,Lee, Jae Sung,Cheon, Gi Jeong,Lee, Dong Soo,Chung, June-Key,Kang, Keon Wook The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.1
<P>The purpose of this study was to estimate average radiation exposure from <SUP>18</SUP>F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) examinations and to analyze possible factors affecting the radiation dose. A nation-wide questionnaire survey was conducted involving all institutions that operate PET/CT scanners in Korea. From the response, radiation doses from injected FDG and CT examination were calculated. A total of 105 PET/CT scanners in 73 institutions were included in the analysis (response rate of 62.4%). The average FDG injected activity was 310 ± 77 MBq and 5.11 ± 1.19 MBq/kg. The average effective dose from FDG was estimated to be 5.89 ± 1.46 mSv. The average CT dose index and dose-length product were 4.60 ± 2.47 mGy and 429.2 ± 227.6 mGy∙cm, which corresponded to 6.26 ± 3.06 mSv. The radiation doses from FDG and CT were significantly lower in case of newer scanners than older ones (<I>P</I> < 0.001). Advanced PET technologies such as time-of-flight acquisition and point-spread function recovery were also related to low radiation dose (<I>P</I> < 0.001). In conclusion, the average radiation dose from FDG PET/CT is estimated to be 12.2 mSv. The radiation dose from FDG PET/CT is reduced with more recent scanners equipped with image-enhancing algorithms.</P>
( Sung Ae Woo ),( Hye Young Ju ),( Soon Hyo Kwon ),( Ji Hye Lee ),( Soo Jeong Choi ),( Dong Cheol Han ),( Seung Duk Hwang ),( Sae Yong Hong ),( So Young Jin ),( Hyo Wook Gil ) 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.4
Background: All types of membranoproliferative glomerulonephritis (MPGN) areprogressive diseases with poor prognoses. Recently, a newly proposed classificationof these diseases separated them into immune complex- and complementmediateddiseases. We investigated the frequency of C3 glomerulonephritis amongpreviously diagnosed MPGN patients. Methods: We conducted a retrospective study of patients diagnosed with MPGN atthree tertiary care institutions between 2001 and 2010. We investigated theincidence of complement-mediated disease among patients diagnosed with MPGN. Progressive renal dysfunction was defined as a 50% reduction in the glomerularfiltration rate or the need for renal replacement therapy. Results: Among the 3,294 renal biopsy patients, 77 (2.3%) were diagnosed withMPGN; 31 cases were excluded, of which seven were diagnosed with systemic lupusnephritis, and the others were not followed for a minimum of 12 months afterbiopsy. Based on the new classification, complement-mediated MPGN was diagnosedin two patients (4.3%); only one patient developed progressive renaldysfunction. Among the immune complex-mediated MPGN patients, 17 patientsdeveloped progressive renal dysfunction. Serum albumin and creatinine levels atthe time of MPGN diagnosis were risk factors of renal deterioration, after adjustingfor low C3 levels and nephrotic syndrome. Conclusion: Complement-mediated glomerulonephritis was present in 4.3% ofpatients previously diagnosed with MPGN.
Kwon, Minsu,Kim, Shin-Ae,Roh, Jong-Lyel,Lee, Sang-Wook,Kim, Sung-Bae,Choi, Seung-Ho,Nam, Soon Yuhl,Kim, Sang Yoon AlphaMed Press 2016 The oncologist Vol.21 No.9
<P>Introduction. Frailty refers to a decreased physiologic reserve in geriatric patients and its importance in terms of treatment planning and outcome prediction has been emphasized in oncologic practices for older patients with cancer. We investigated the clinical implications of a head and neck cancer (HNC)-specific frailty index suggested by prospective clinical and functional evaluations of HNC patients. Materials and Methods. We analyzed data on 165 elderly patients with HNC who were prospectively enrolled in our hospital from 2010 to 2013. Pretreatment functional evaluations were performed according to all comprehensive geriatric assessment (CGA) domains. We additionally evaluated the patients' respiratory and swallowing functions using pulmonary function tests, voice handicap index (VHI), MD Anderson Dysphagia Inventory (MDADI), and other associated tests. Factors affecting the 2-year morbidity and mortality were also analyzed. Results. Respiratory and swallowing problems were major causes of 2-year morbidity. Pretreatment performance status, VHI >= 8, MDADI <70, dental problems, and chemotherapy were significantly associated with early morbidity and mortality (all p < .05). CGA-assessed frailty was found in 72 patients (43.6%) and was significantly associated with 2-year mortality (p = .027) but not with morbidity (p = .716). The high-risk group according to our new HNC-specific frailty index that included functional evaluations of respiration and swallowing showed significantly higher 2-year morbidity (p = .043) and mortality (p < .001). Conclusion. Pretreatment functional disabilities related to respiration and swallowing were significantly associated with early morbidity and mortality. The suggested index would be more useful for assessing frailty in elderly HNC patients.</P>